THE DEFICIT AT RUIN IN THE SPARRE ANDERSEN MODEL WITH INTEREST

Bao, Zhen-Hua,Ye, Zhong-Xing 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1

In this paper, we consider the Sparre Andersen risk model modified by the inclusion of interest on the surplus. By using the techniques of Cai and Dickson [Ins.: Math. Econ. 32(2003)], we give the functional and also the exponential type upper bounds for the tail probability of the deficit at ruin. Some special cases are also discussed.

The deficit at ruin in the Sparre Andersen model with interest

ZHEN-HUA BAO,ZHONG-XING YE 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1

In this paper, we consider the Sparre Andersen risk model modified by the inclusion of interest on the surplus. By using the techniques of Cai and Dickson [Ins.: Math. Econ. 32(2003)], we give the functional and also the exponential type upper bounds for the tail probability of the deficit at ruin. Some special cases are also discussed.

Asymptotic distribution of the discounted proper deficit in the discrete time delayed renewal model

Zhen-hua Bao,Jing Wang 대한수학회 2011 대한수학회보 Vol.48 No.2

In this paper we consider the discrete time delayed renewal risk model. We investigate what will happen when the distribution function of the discounted proper deficit is asymptotic in the initial surplus. In doing this we establish several lemmas regarding some related ruin quantities in the discrete time delayed renewal risk model, which are of significance on their own right.

ASYMPTOTIC DISTRIBUTION OF THE DISCOUNTED PROPER DEFICIT IN THE DISCRETE TIME DELAYED RENEWAL MODEL

Bao, Zhen-Hua,Wang, Jing Korean Mathematical Society 2011 대한수학회보 Vol.48 No.2

In this paper we consider the discrete time delayed renewal risk model. We investigate what will happen when the distribution function of the discounted proper deficit is asymptotic in the initial surplus. In doing this we establish several lemmas regarding some related ruin quantities in the discrete time delayed renewal risk model, which are of significance on their own right.

Two new species of Panorpa (Mecoptera, Panorpidae) from the Hengduan Mountains in Yunnan, China

Ning Li,Bao-zhen Hua 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.1

Two new species of the genus Panorpa Linnaeus, 1758 are described from the Hengduan Mountains in Yunnan, China. Panorpa diqingensis sp. n. can be distinguished from its congeners by vertex dark brown, and occiput yellow; pleura dark brown; gonocoxites bearing a cluster of stout black setae on inner apex; parameres S-shaped in male genitalia. Panorpa dispergens sp. n. can be readily differentiated from other Panorpa species by apical band with a hyaline spot in wings; gonocoxites with a cluster of stout dark brown setae and 3–5 long setae on inner apex; female medigynium with a pair of basal plates. The number of Panorpa species in Yunnan is raised to six. A key to Yunnan species of Panorpa is presented.

Proboscis sensilla of the black cutworm Agrotis ypsilon (Rottemberg) (Lepidoptera: Noctuidae)

Shuang Xue,Bao-zhen Hua 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.3

Proboscis sensilla are important for feeding biology in Lepidoptera, and are also valuable characters for speciesrecognition and phylogenetic analysis. However, proboscis has not been satisfactorily explored in many groupsin Lepidoptera so far. Here weexamined the proboscis sensilla of the black cutworm Agrotis ypsilon (Rottemberg),a cosmopolitan agricultural pest of great economic significance, using scanning electron microscopy. Three typesof sensilla were found on the proboscis: sensilla chaetica, sensilla basiconica, and sensilla styloconica. Sensillachaetica occur only on the external surface of the proboscis and become shorter and more scattered towardthe tip. Sensilla basiconica are arranged in longitudinal rows on the external proboscis and one longitudinalrow in the inner food canal. Sensilla styloconica are the most characteristic sensilla on the proboscis, consistingof a single sensory cone inserted at the top of a stylus with six or seven longitudinal ribs, and are concentratedon the tip region, and aremuch longer andmore numerous in females than inmales. The role of proboscis sensillain the feeding habit prediction is briefly discussed.

Morphology of the immature stages of Arge pagana (Panzer, 1798) (Hymenoptera: Argidae) with notes on its biology

Ya-Guang Zhao,Bao-zhen Hua 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.4

The immature stages of the large rose sawfly Arge pagana (Panzer, 1798)were investigated using light and scanning electron microscopy. The egg is partly inserted into the tissue of twigs of Rosa chinensis (Jacq.). The chorion in the plant tissue is furnished with irregular polygonal network and aeropyles, but the exposed portion of chorion is glabrous and aporous. Ten to twelve micropyles were on the posterior pole of eggs. The eruciform larva bears five pairs of ventral prolegs on abdominal segments II–VI and a pair of anal prolegs on segment X. A pair of prominent stemmata is present on the lateral side of head dorsal to the 1-segmented antennae. Male larvae have five instars, but female larvae have six instars. When fully-grown, the larvae move to the ground and spin cocoons to pupate inside. The exarate and decticous pupae are yellow, taking the shape of the adults. This species completes four generations per year, overwintering as prepupae in cocoons. The durations of egg, larva, prepupa, and pupa are 10–15, 19–24, 8–12, and 3–5 days, respectively.

Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin

Hai-Yan Zhang,Zhen-Xian Du,Bao-Qin Liu,Yan-Yan Gao,Xin Meng,Yifu Guan,Wei-Wei Deng,Hua-Qin Wang 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5

TNF-related apoptosis-inducing ligand (TRAIL) has been proposed as a promising cancer therapy that preferentially induces apoptosis in cancer cells, but not most normal tissues. However, many cancers are resistant to TRAIL by mechanisms that are poorly understood. In this study, we showed that tunicamycin, a naturally occurring antibiotic, was a potent enhancer of TRAIL-induced apoptosis through downregulation of survivin. The tunicamycin-mediated sensitization to TRAIL was efficiently reduced by forced expression of survivin, suggesting that the sensitization was mediated at least in part through inhibition of survivin expression. Tunicamycin also repressed expression of cyclin D1, a cell cycle regulator commonly overexpressed in thyroid carcinoma. Furthermore, silencing cyclin D1 by RNA interference reduced survivin expression and sensitized thyroid cancer cells to TRAIL; in contrast, forced expression of cyclin D1 attenuated tunicamycin-potentiated TRAIL-induced apoptosis via over-riding downregulation of survivin. Collectively, our results demonstrated that tunicamycin promoted TRAIL-induced apoptosis, at least in part, by inhibiting the expression of cyclin D1 and subsequent survivin. Of note, tunicamycin did not sensitize the differentiated thyroid epithelial cells to TRAIL-induced apoptosis. Thus, combined treatment with tunicamycin and TRAIL may offer an attractive strategy for safely treating resistant thyroid cancers. TNF-related apoptosis-inducing ligand (TRAIL) has been proposed as a promising cancer therapy that preferentially induces apoptosis in cancer cells, but not most normal tissues. However, many cancers are resistant to TRAIL by mechanisms that are poorly understood. In this study, we showed that tunicamycin, a naturally occurring antibiotic, was a potent enhancer of TRAIL-induced apoptosis through downregulation of survivin. The tunicamycin-mediated sensitization to TRAIL was efficiently reduced by forced expression of survivin, suggesting that the sensitization was mediated at least in part through inhibition of survivin expression. Tunicamycin also repressed expression of cyclin D1, a cell cycle regulator commonly overexpressed in thyroid carcinoma. Furthermore, silencing cyclin D1 by RNA interference reduced survivin expression and sensitized thyroid cancer cells to TRAIL; in contrast, forced expression of cyclin D1 attenuated tunicamycin-potentiated TRAIL-induced apoptosis via over-riding downregulation of survivin. Collectively, our results demonstrated that tunicamycin promoted TRAIL-induced apoptosis, at least in part, by inhibiting the expression of cyclin D1 and subsequent survivin. Of note, tunicamycin did not sensitize the differentiated thyroid epithelial cells to TRAIL-induced apoptosis. Thus, combined treatment with tunicamycin and TRAIL may offer an attractive strategy for safely treating resistant thyroid cancers.

Five new species of Dicerapanorpa Zhong & Hua (Mecoptera, Panorpidae) from Yunnan, China

Gui-Lin Hu,Ji-Shen Wang,Bao-zhen Hua 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1

Five new scorpionfly species of the genus Dicerapanorpa Zhong and Hua, 2013 are described and illustrated from Yunnan Province, China. Dicerapanorpa macula sp. n. can be readily recognized by all branches of paramere parallel, basal and mesal branches extending well beyond basal process of gonostylus in male, and posterior arm of medigynium short and stout in female. Dicerapanorpa deqenensis sp. n. is characterized by basal branch of paramere as long as lateral branch and ventral valve of aedeagus nearly reaching apex of gonocoxite in male, and medigynium with paired auricular lateral processes in female. Dicerapanorpa tanae sp. n. is unique by genital bulb broad and spherical, basal branch of paramere short, and lateral branches curved convergently and parallel apically in male, and main plate of medigynium rounded in female. Dicerapanorpa tenuis sp. n. is distinguishable by hypovalve with largely expanded and inward curved apex and all branches of paramere reaching or exceeding apex of gonocoxite in male, and medigynium slender in female. Dicerapanorpa zhongdianensis sp. n. is characterized by basal branches of paramere parallel and mesal branches curved convergently in male, and main plate of medigynium subtriangular with a pair of auricular lateral processes in female. The species number of Dicerapanorpa is increased to thirteen.

Characteristics and Impact Factors of Renal Threshold for Glucose Excretion in Patients with Type 2 Diabetes Mellitus

Xiao-Dan Yue,Jing-Yu Wang,Xin-Rong Zhang,Ju-Hong Yang,Chun-Yan Shan,Miao-Yan Zheng,Hui-Zhu Ren,Yi Zhang,Shao-Hua Yang,Zhen-Hong Guo,Bai Chang,Bao-Cheng Chang 대한의학회 2017 Journal of Korean medical science Vol.32 No.4

Sodium glucose co-transporter 2 (SGLT-2) inhibitors are newly developed but promising medicine for type 2 diabetes. However, patients with a different renal threshold for glucose excretion (RTG) may have a different reaction to this medicine. Therefore, the objective of this study was to investigate the characteristics of RTG and its impact factors in patients with type 2 diabetes mellitus (T2DM). The clinical and laboratory data of 36 healthy individuals and 168 in-hospital patients with T2DM were collected and analyzed, RTG was calculated using blood glucose (BG) measured by dynamic BG monitoring, urinary glucose excretion (UGE) and estimated glomerular filtration rate (eGFR). The characteristics of RTG were investigated. The risk factors for high RTG were analyzed using non-conditional logistic regression analysis. Our results found that RTG of the T2DM group was higher than that of the healthy individuals (P < 0.05); and 22.22% from the healthy individuals group but 58.33% from the T2DM group had high RTG. Age, duration of diabetes, body mass index (BMI), and homeostasis model assessment insulin resistance index (HOMA-IR) were independently associated with high RTG (P < 0.05). Further stratified analysis revealed that RTG in T2DM patients increased with age, duration of diabetes, and BMI. In conclusion, RTG is increased in patients with T2DM, especially in those with longer diabetic duration, higher BMI, and those who are older. Therefore, these patients may be more sensitive to SGLT-2 inhibitors.