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- 저자 : Yuxuan Tao (검색결과 2 건)
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Lu Tan,Jing Ou,Zezhang Tao,Yonggang Kong,Yuxuan Zhang 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.2
Purpose: Maternal influences contribute to the origin of allergic diseases, but the mechanisms are not clear. The current literature prompted the role of epigenetics in the development of allergic diseases. We sought to investigate the roles of regulatory T (Treg) cells and Forkhead box p3 (Foxp3) DNA methylation in the process of maternal transmission of allergic rhinitis (AR) susceptibility. Methods: BALB/c female mice (AR mother) were sensitized by intraperitoneal injection of Dermatophagoides pteronyssinus (Der p) 1 on day 1 and 7. Then they mated with normal male mice on day 8. From day 21 to 28, the female mice were intranasal challenged with Der p 1 continuously. The normal controls were given with normal saline in the same way. On postnatal day 3, Female mice and their offspring were sacrificed to detect their histopathology in nasal mucosae, cytokines in sera of mother and spleen homogenates of offspring, Treg cells count, Foxp3 mRNA expressions, and Foxp3 DNA methylation levels in spleens. Results: Compared with the normal controls, neonatal offspring of Der p 1-stimulated female mice (AR offspring) showed the elevation of interleukin (IL)-4 (P<0.01) and IL-17 (P<0.01), the submission of IL-10 (P<0.01) in spleen homogenates. Further, Treg cells count in AR offspring decreased remarkably compared with the normal offspring (P<0.01). Though the difference of Foxp3 DNA methylation level between AR offspring and normal control offspring was not obvious, correlation analysis demonstrated that there was significantly positive correlation between Foxp3 DNA methylation level of mother and that of offspring (r=0.803, P<0.01). Conclusions: Under the influence of Maternal AR, their neonatal offspring develop into T-helper type 2 (Th2) dominant immune state, which is closely associated with the recession of Treg cells. Foxp3 DNA methylation may be a mechanism responsible for that maternal effect but still need more studies to ensure.
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Xiufeng Liu,Wei Wei,JinChun Yuan,Yuxuan Tao,Yuheng Li,Yu Huang 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.11
For the ultra-precision turning machine, the spindle system is a core component and plays a decisive role in precise machining. The unbalancing state in the spindle can degrade the quality of the machining surface. Therefore, the spindle system must be exceptionally well balanced before processing. In this paper, we proposed a high accuracy spindle balance method, which adopts the real-time data in the CNC system and combines with disturbance observer (DOB) to estimate the unbalancing vector without any extra sensors. Moreover, this method takes full advantage of the ultra-precision machine structure, the high precision grating, and the high-performance motor servo system to achieve high accuracy measurement for the spindle unbalancing. According to the experimental results, the proposed method accuracy is up to G0.0073, which is at least three levels greater than the highest official ISO balancing quality grade G0.16. In the cutting experiments, the PV value reduce to 0.207 μm from 0.528 μm with upgrading the spindle balance grade to G0.01024 from G0.16, verifies the accuracy of the spindle dynamic balancing method from the practice side.
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