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CLAY NANOTUBES FOR ENCAPSULATION AND SUSTAINED RELEASE OF DRUGS
NALINKANTH G. VEERABADRAN,RONALD R. PRICE,YURI M. LVOV 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.2
50-nm diameter halloysite clay nanotubules with 15 nm lumen were used for loading poorly soluble drugs and sustaining their release. Loading was optimized by varying pH and alcohol/water ratio in the solvent with a maximum drug loading of 12 volume%. Near linear release of Dexamethasone, Furosemide, and Nifedipine was demonstrated for 5–10 hours. Its capacity for the time release of drugs, along with its simple loading procedure and the biocompatibility of halloysite nanotubules makes this method a prospective drug delivery system.