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A Variable Neighbourhood Descent Algorithm for the Redundancy Allocation Problem
Liang, Yun-Chia,Wu, Chia-Chuan Korean Institute of Industrial Engineers 2005 Industrial Engineeering & Management Systems Vol.4 No.1
This paper presents the first known application of a meta-heuristic algorithm, variable neighbourhood descent (VND), to the redundancy allocation problem (RAP). The RAP, a well-known NP-hard problem, has been the subject of much prior work, generally in a restricted form where each subsystem must consist of identical components. The newer meta-heuristic methods overcome this limitation and offer a practical way to solve large instances of the relaxed RAP where different components can be used in parallel. The variable neighbourhood descent method has not yet been used in reliability design, yet it is a method that fits perfectly in those combinatorial problems with potential neighbourhood structures, as in the case of the RAP. A variable neighbourhood descent algorithm for the RAP is developed and tested on a set of well-known benchmark problems from the literature. Results on 33 test problems ranging from less to severely constrained conditions show that the variable neighbourhood descent method provides comparable solution quality at a very moderate computational cost in comparison with the best-known heuristics. Results also indicate that the VND method performs with little variability over random number seeds.
Significant Structure Theory of Physical Adsorption
Yun-liang Wang,Taikyue Ree,Henry Eyring Korean Chemical Society 1971 대한화학회지 Vol.15 No.5
A significant structure theory of monolayer physical adsorption is developed. The theory is tested with the adsorptions on graphite of gases Ar, $N_2$, $CHCl_3$, and $CCl_4$. A restricted rotation model is used for the polyatomic molecules $N_2$, $CHCl_3$, and $CCl_4$. The computed isotherms and heats of adsorption are in good agreement with experiment in all cases studied.
Wang, Yun-Liang,Dong, Feng-Lin,Yang, Jian,Li, Zhi,Zhi, Qiao-Ming,Zhao, Xin,Yang, Yong,Li, De-Chun,Shen, Xiao-Chun,Zhou, Jin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Epidermal growth factor-like domain multiple 7 (EGFL7), a secreted protein specifically expressed by endothelial cells during embryogenesis, recently was identified as a critical gene in tumor metastasis. Epithelial-mesenchymal transition (EMT) was found to be closely related with tumor progression. Accordingly, it is important to investigate the migration and EMT change after knock-down of EGFL7 gene expression in human pancreatic cancer cells. Materials and Methods: EGFL7 expression was firstly testified in 4 pancreatic cancer cell lines by real-time polymerase chain reaction (Real-time PCR) and western blot, and the highest expression of EGFL7 was found in PANC-1 cell line. Then, PANC-1 cells transfected with small interference RNA (siRNA) of EGFL7 using plasmid vector were named si-PANC-1, while transfected with negative control plasmid vector were called NC-PANC-1. Transwell assay was used to analyze the migration of PANC-1 cells. Real-time PCR and western blotting were used to detect the expression change of EGFL7 gene, EMT markers like E-Cadherin, N-Cadherin, Vimentin, Fibronectin and transcription factors like snail, slug in PANC-1, NCPANC-1, and si-PANC-1 cells, respectively. Results: After successful plasmid transfection, EGFL7 gene were dramatically knock-down by RNA interference in si-PANC-1 group. Meanwhile, migration ability decreased significantly, compared with PANC-1 and NC-PANC-1 group. Meanwhile, the expression of epithelial phenotype marker E-Cadherin increased and that of mesenchymal phenotype markers N-Cadherin, Vimentin, Fibronectin dramatically decreased in si-PANC-1 group, indicating a reversion of EMT. Also, transcription factors snail and slug decreased significantly after RNA interference. Conclusions: Current study suggested that highly-expressed EGFL7 promotes migration of PANC-1 cells and acts through transcription factors snail and slug to induce EMT, and further study is needed to confirm this issue.
Energy-Efficient Yaw Moment Control for Humanoid Robot Utilizing Arms Swing
Liang Yang,Zhi Liu,Yun Zhang 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.9
Due to the fact that the undesired yaw moment is inevitably generated during humanoid robot walks, it is thus impossible to ignore its existence to achieve the excellent dynamic balance. In this paper, the problem of yaw moment control for humanoid robot is investigated. First we analyze the the moment equilibrium conditions of yaw axis and formulate a constrained dynamic model of arms swing. To counteract the unexpected yaw moment with the consideration of energy efficiency and physical constraints, a novel armsswing- based approach is proposed. Moreover, one online QP solver is adopted to deal with the optimization problem with both inequality and equality constraints, which is examined to alleviate the burdensome energy consumption. Finally, simulation results verify the effectiveness of the proposed method.
Vascular-specific activity of the Arabidopsis carotenoid cleavage dioxygenase 7 gene promoter.
Liang, Ying Shi,Jeon, Yun-A,Lim, Sun-Hyung,Kim, Jae Kwang,Lee, Jong-Yeol,Kim, Young-Mi,Lee, Yeon-Hee,Ha, Sun-Hwa Springer 2011 Plant cell reports Vol.30 No.6
<P>Carotenoid cleavage dioxygenases (CCDs) are involved in the production of diverse apocarotenoids including phytohormones, the visual molecules and the aromatic volatile compounds derived from carotenoids. Here, we examined the spatial expression of four of the CCD genes (AtCcd1, 4, 7 and 8) among the nine members of this family in Arabidopsis by RT-PCR. We found that the AtCcd7 gene showed strong expression in seeds. However, the promoter activity of the 1,867-bp 5'-upstream region of this gene exhibited a vascular specificity at all developmental stages throughout the transgenic Arabidopsis plants tested. The strength of the AtCcd7 promoter was also found to be lower than that of the 35S promoter by about 60%. The whole body expression of the beta-glucuronidase (GUS) reporter gene driven by the AtCcd7 promoter in Arabidopsis plants was confirmed in different organs by RT-PCR and GUS enzymatic assays. Histochemical GUS staining further revealed that the AtCcd7 promoter has utility in limiting the expression of target genes to the vascular tissues in all plant organs such as the leaf, stem, root, flower and seed.</P>