A Typhoon Recognition and Center Position Method based on Fengyun-2 Satellites Data

Wei Tian,Liguang Wu,Weican Zhou,Yuhui Zheng,Jin Wang 보안공학연구지원센터 2014 International Journal of u- and e- Service, Scienc Vol.7 No.6

The recognition and center position methods of typhoon with high accuracy are essential for forecasting and monitoring of tropical cyclones (TCs) in the meteorological applications. We designed the improved adaptive threshold processing algorithms and segmentation of typhoon cloud system by using two value image connecting region labeling algorithm. It shows potential ability in typhoon cloud feature and the recognition of typhoon cloud system in northern hemisphere. We also designed algorithms of locating typhoon center by mathematical morphology. Experimental results show that the typhoon cloud system can be effectively recognized on could imagery and the center of cloud imagery can also be located by the proposed method. Our analysis indicated that typhoon recognition and center position accuracy based on FY-2 satellites data were high recognition rate and accuracy of the center location, and the methods can be applied to meteorological business systems.

A Survey on Clustering based Meteorological Data Mining

Wei Tian,Yuhui Zheng,Runzhi Yang,Sai Ji,Jin Wang 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.6

Data mining is an important tool in meteorological problems solved. Cluster analysis techniques in data mining play an important role in the study of meteorological applications. The research progress of the clustering algorithms in meteorology in recent years is summarized in this paper. First, we give a brief introduction of the principles and characteristics of the clustering algorithms that are commonly used in meteorology. On the other hand, the applications of clustering algorithms in meteorology are analyzed, and the relationship between the various clustering algorithms and meteorological applications are summarized. Then we interpret the relationship from the perspectives of algorithms’ characteristics and practical applications. Finally, some main research issues and directions of the clustering algorithms in meteorological applications are pointed out.

Gastroprotective effect of cirsilineol against hydrochloric acid/ethanol-induced gastric ulcer in rats

Guojin Gong,Rigetu Zhao,Yuhui Zhu,Jinfeng Yu,Bin Wei,Yan Xu,Zhaoxun Cui,Guoying Liang 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.5

This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced rats. The gastroprotective ability was verified by determining the ulcer score, total acidity, hemoglobin, inflammatory cytokines, lipid peroxides, and enzymatic antioxidants superoxide dismutase (SOD) and catalase (CAT) in gastric tissue and serum biochemical analysis. The results showed a favorable increase in the hemoglobin level, antioxidant enzymes (SOD and CAT), restored electrochemical balance (carbon dioxide & anion gap) while a noticeable decrease in ulcer index, total acidity, lipid peroxides, inflammatory cytokines (interleukin-1 beta [IL-1β], IL-6, and tumor necrosis factor alpha) in rats treated with the cirsilineol. The serum biochemical analysis on liver markers (alkaline phosphatases, alanine aminotransferase, and aspartate aminotransferase), kidney markers (urea, creatinine, albumin, globulin, total protein), and lipid profile (triglyceride, high-density lipoprotein, total cholesterol) were attenuated by cirsilineol treatment in rats. Histopathology showed enhanced gastric protection and preserved the integrity of gastric mucosa upon cirsilineol administration. These results ultimately suggest that cirsilineol has gastroprotective effects that prevent the development of gastric ulcer.

Effects of Pluronic F68 and Labrasol on the Intestinal Absorption and Pharmacokinetics of Rifampicin in Rats

Li Ma,Xin'an Wu,Yuhui Wei,Yan Zhou,Xiaohua Ma 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11

The aim of this study was to investigate the effects of Pluronic F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin. Intestinal permeability of rifampicin with or without excipients was evaluated by an in situ single-pass perfusion method. A highperformance liquid chromatographic method was applied to study the pharmacokinetics of rifampicin with or without excipients. Labrasol or Pluronic F68 (0.1% and 0.05%, v/v), co-perfused with rifampicin (60 μg/mL), significantly increased in situ permeability. Similarly, verapamil (a typical P-gp inhibitor) also increased in situ permeability, but to a lesser extent. In vivo, the oral administration of rifampicin with or without Pluronic F68, Labrasol or verapamil resulted in statistically significant effect on t1/2 (4.83 to 7.75, 6.42 and 7.46 h) and total body clearance (0.46 to 0.26, 0.28, 0.24 L/h/kg). In addition, Pluronic F68, Labrasol and verapamil produced minor changes in AUC_0-t, which improved 1.55-, 1.54-, and 1.73-fold in comparison to control group, respectively. These results showed that Labrasol and Pluronic F68 might inhibit the function of P-gp in the intestine, thereby increasing intestinal absorption and changing the pharmacokinetic parameters of rifampicin. Therefore, excipient selection is an important factor to consider in rational formulation design.

Simulation Research of Multi-morphological Microstructures Chaining Mechanism of Nano-magnetic Fluid

Lei Yang,Yibiao Chen,Yao Yao,Shuaikang Wei,Yuhui Xie,Decai Li,Jun Yu,Hongming Zhou,Yiping Feng 한국자기학회 2024 Journal of Magnetics Vol.29 No.1

For nano-magnetic fluid(NMF), the magnetic nano-particle(MNP) kinematic behavior in a magnetic field and the chain-like microstructure evolution are important to study the NMF properties at the microscopic level. However, the chain structure formation mechanism and the effects of multiple environmental factors on microstructural morphology remain unclear. In this paper, the interaction of a two-particle system, chain structure formation process, microstructure evolution and response time simulation of NMF is investigated by the discrete element simulation method. The results show that the magnetic dipole and repulsive forces dominate the chain structure formation and evolution under a uniform magnetic field. MNPs assemble into chain-like structures and various complex structures along the magnetic f ield direction. The volume fraction, magnetization intensity and particle size significantly affect the microstructure and the response time. The above study can obtain the specific morphology of the microstructure at different working conditions and broaden the application of NMF in practical engineering.

Increased brain uptake of venlafaxine loaded solid lipid nanoparticles by overcoming the efflux function and expression of P-gp

Yan Zhou,Xin’an Wu,Guo-Qiang Zhang,Zhi Rao,Yang Yang,Qian Zhou,Hongyan Qin,Yuhui Wei 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.7

Venlafaxine (VLX) could be pumped out of the brain by P-glycoprotein (P-gp). Moreover, the expression of P-gp distributed in blood–brain barrier could be significantly induced by VLX. Thus, P-gp could be considered as the nature barrier for delivering of VLX to the brain. The aim of this study was to investigate whether the efflux function and increased expression of P-gp could be reversed by utilizing solid lipid nanoparticles (SLN). VLX solid lipid nanoparticles (VLX - SLN) were prepared and evaluated. Pharmacokinetics and brain distribution of VLX in different formulations were conducted after oral or intravenous administration. P-gp efflux function to VLX was evaluated by the brain uptake amount of VLX, while P-gp expression was investigated by Western blotting. Results indicated that the entrapment, mean size and zata potential of VLX - SLN was 74.9 ± 3.0 %, 186.3 ± 69.26 nm and -22.8 ± 7.78 mv, respectively. After vein injection of VLX formulations, the brain uptake amount of VLX from VLX - SLN was significantly higher than that of VLX solution, VLX solution with empty SLN (VLX? empty SLN) and VLX solution with Verapamil (VLX ? Ver), respectively. Furthermore, the protein mass of P-gp in VLX - SLN treated group was the lowest among all the investigated groups. These results indicated that SLN could overcome P-gp and achieve brain target by intravenous administration.