Enhancing proliferation and ECM expression of human ACL fibroblasts by sonic vibration.

Jiang, Yuan-Yuan,Park, Jung-Keug,Yoon, Hee-Hoon,Choi, Hynjin,Kim, Chan-Wha,Seo, Young-Kwon MARCEL DEKKER, INC 2015 PREPARATIVE BIOCHEMISTRY AND BIOTECHNOLOGY Vol.45 No.5

<P>Effects of mechanical vibration on cell activity and behavior remain controversial: There has been evidence on both positive and negative effects. Furthermore, research on the anterior cruciate ligament (ACL) has as yet been limited and the frequency-related effects remain unknown, even though ACL injury is common and an injured ACL hardly spontaneously recovers. The object of this work was to address the influence of mechanical vibration on ACL fibroblasts, to determine the effects of frequencies, and to further study this effect at the cellular level. We found that sonic vibration affected ACL fibroblasts' proliferation and metabolism in a frequency-dependent manner, and 20?Hz gave rise to the most ACL cell activity and comprehensively increased extracellular matrix (ECM) contents, including collagen type I, collagen type III, fibronectin, elastin, tenascin, glycosaminoglycan (GAG), and the cytoskeleton protein vimentin. Thus, our results indicate that sonic vibration possesses frequency-dependent effects on proliferation and productivity of ACL fibroblast with an optimal frequency of 20?Hz under the present stimulation conditions, providing further information for future research in how vibrational stimulation manipulates ACL cellular behavior.</P>

fabrication of PHBV/Keratin Composite Nanofibrous Mats for Biomedical Applications

Jiang Yuan,Zhi Cai Xing,Suk Woo Park,Jia Geng,Inn Kyu Kang,Jian Shen,Wan Meng,Kyoung Jin Shim,In Suk Han,Jung Chul Kim 한국고분자학회 2009 Macromolecular Research Vol.17 No.11

Electromagnetic-Mechanical Analysis of a Balanced Armature Receiver by Considering the Nonlinear Parameters as a Function of Displacement and Current

Jiang, Yuan-Wu,Xu, Dan-Ping,Hwang, Sang-Moon IEEE 2018 IEEE transactions on magnetics Vol.54 No.11

<P>A balanced armature receiver is a multi-physics product in which there is a coupling between the electromagnetic and mechanical domains. To come up with a more accurate analysis method, the nonlinear parameters are considered as functions of current and displacement based on the finite-element method. The current and displacement are solved using the voltage equation through the numerical iteration method. Simulation results are verified through experiments.</P>

詩之 "體" 與 詩之 "用": 船山詩學的兩個向度及其中介

Yuan Jiang Zou 퇴계학부산연구원 2010 退溪學論叢 Vol.16 No.-

The first dimension in Chuan-shan poetics is "value"of poetry in orthodox Confucian poetics which is consistent with his philosophy tendency, which includes "emperor manners", "morals and manners", "poetic education", "ethical education" etc, this is identical in point with Confucian poetics. The second dimension in Chuan-shan poetics is"body"of poetry which is related to his aesthetic interest, which is the comprehension of the imagery formation characteristics in poetry. It gives the interpretation that poetry, what lives in the nether or bright occasion(You-ming) in "study of Heaven's mandate" of the book "Shi Guang Zhuan", which explored some dimensions in the "body" of poetry. So its conspicuous that Chuan-shan poetics has its own problems: that while it lay too much stress on objective poetic education, it will easy to make departure of "value" and tend toward "body" in poetry; in contrast, while it make clear the imagery aesthetic features in non-objective world, it will be hard to reach the "value" of objective poetic education. But when it goes to"Xin Zhi Guang"at the meaning of "Xin Sheng Yu Yu Li", the perspective view will surpass the bounds of politics, morals, ethics, turned to be a indecisive boundaries intermediary perspective view in the "value" of poetry which has significant value to reach the "body" of poetry in the perspective of aesthetics.

Therapeutic Efficacy of Urethral Sphincter Injections of Platelet- Rich Plasma for the Treatment of Stress Urinary Incontinence due to Intrinsic Sphincter Deficiency: A Proof-of-Concept Clinical Trial

Yuan-Hong Jiang,Ping-Jui Lee,Hann-Chorng Kuo 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.1

Purpose: The aim of this study was to investigate the efficacy of autologous platelet-rich plasma (PRP) in the treatment of stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD) refractory to medical treatment. Methods: Thirty-five patients with SUI due to urodynamically proven ISD were prospectively enrolled. Five milliliters of PRP (2.5–5 times the platelet concentration in peripheral blood) was injected into the external sphincter at 5 sites; all patients received 4 injections at monthly intervals. The primary end-point was the change in SUI severity as assessed by a visual analogue scale (VAS of SUI). The secondary-endpoints were the Global Response Assessment score and changes in urodynamic parameters from baseline to 3 months after treatment. Results: The mean age of patients was 68.7±12 years; the median duration of SUI was 4 years. Five patients had neurogenic SUI, while 30 had nonneurogenic SUI (21 with postprostatectomy incontinence, 6 with previous radical cystectomy, and 3 with other etiologies). Complete dryness was achieved in 7 patients (20.0%) while moderate improvement was observed in 14 (40.0%). The mean VAS of SUI score decreased significantly from 6.57±1.89 to 3.77±2.41 after treatment. The abdominal leak point pressure (ALPP) increased significantly from 98.3±55.8 to 157.3±79.3 cm H2O. There was no increase of ALPP in neurogenic SUI and less increase of ALPP in patients with failed treatment outcomes. No perioperative adverse events or severe complications occurred. Conclusions: Urethral PRP injection is safe and effective in increasing urethral resistance and improving SUI. PRP could be an alternative treatment modality for male and female patients with moderate SUI due to nonneurogenic causes.

Frontiers in the Clinical Applications of Botulinum Toxin A as Treatment for Neurogenic Lower Urinary Tract Dysfunction

Yuan-Hong Jiang,Sheng-Fu Chen,Hann-Chorng Kuo 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.4

Patients with neurogenic lower urinary tract dysfunction (NLUTD) experience urinary incontinence with or without difficult urination, which might promote recurrent urinary tract infection (UTI) and exacerbate upper urinary tract function. Nonetheless, appropriate bladder management has been shown to reduce urological complications and improve quality of life. In addition to pharmacological therapy and surgical intervention, botulinum toxin A (BoNT-A) has been widely utilized in NLUTD. The therapeutic efficacy of detrusor BoNT-A injections for neurogenic detrusor overactivity due to spinal cord injury (SCI), multiple sclerosis, or other central nervous system lesions, such as cerebrovascular accident, Parkinson disease, early dementia, and pediatric NLUTD due to myelomeningocele, has been well established, with repeated BoNT-A injections every 6 to 9 months being necessary to maintain its therapeutic effects. Urethral BoNT-A injection can decrease urethral sphincter resistance and facilitate efficient voiding in patients with NLUTD who wish to preserve self-voiding. Detrusor BoNT-A injection can also decrease the occurrence of autonomic dysreflexia in patients with SCI, even after failed augmentation enterocystoplasty, with additional benefits including reduced UTI episodes and preserved renal function with repeated injections. However, this treatment does have some side effects. Complete informed consent for BoNT-A injection therapy with full disclosure of its potential complications should therefore be obtained before this procedure is undertaken.

Three-dimensional cone beam computed tomography analysis of temporomandibular joint response to the Twin-block functional appliance

Yuan-yuan Jiang,Lian Sun,Hua Wang,Chun-yang Zhao,Wei-Bing Zhang 대한치과교정학회 2020 대한치과교정학회지 Vol.50 No.2

Objective: To propose a three-dimensional (3D) method for evaluating temporomandibular joint (TMJ) changes during Twin-block treatment. Methods: Seventeen patients with Class II division 1 malocclusion treated using Twinblock and nine untreated patients with a similar malocclusion were included in this research. We collected their cone beam computed tomography (CBCT) data from before and 8 months after treatment. Segmentations were constructed using ITK-SNAP. Condylar volume and superficial area were measured using 3D Slicer.The 3D landmarks were identified on CBCT images by using Dolphin software to assess the condylar positional relationship. 3D models of the mandible and glenoid fossa of the patients were constructed and registered via voxel-based superimposition using 3D Slicer. Thereafter, skeletal changes could be visualized using 3DMeshMetric in any direction of the superimposition on a color-coded map. All the superimpositions were measured using the same scale on the distance color-coded map, in which red color represents overgrowth and blue color represents resorption. Results: Significant differences were observed in condylar volume, superficial area, and condylar position in bothgroups after 8 months. Compared with the control group (CG), the Twin-block group exhibited more obvious condyle-fossa modifications and joint positional changes. Moreover, on the color-coded map, more obvious condyle-fossa modifications could be observed in the posterior and superior directions in the Twin-block group than in the CG. Conclusions: We successfully established a 3D method for measuring and evaluating TMJ changes caused by Twin-block treatment. The treatment produced a larger condylar size and caused condylar positional changes. [Korean J Orthod 2020;50(2):86-97]

Molecular Analysis and Expression Patterns of the 14-3-3 Gene Family from Oryza Sativa

( Yuan Yao ),( Ying Du ),( Lin Jiang ),( Jin Yuan Liu ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.3

Plasmonic Nanoantennae Fabricated by Focused Ion Beam Milling

Jiang-Tao Lv,Yuan Yan,Wei-Kang Zhang,Yun-Hui Liu,Zi-Yu Jiang,Guang-Yuan Si 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

We show a novel approach to fabricate plasmonic nanoantennae based on a maskless focused ion beam nanoring patterning process. Antenna nanoarrays with desired outlines are achieved by precisely controlling the geometric parameters during the milling process. Various nanoantenna designs of bow-tie, nanoclusters (pentamers), and ellipsoid shaped satellites surrounded particle lattices arerealized. The whole fabrication method is programmable and monolithic since only a one-step milling process is involved. The opticalproperties are experimentally characterized. Such nanoantennae may find extensive applications in chemical/bio-sensing due toremarkably enhanced near field intensity at the plasmon resonance.

The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies

Jiang, Yuan,Hou, Jing,Zhang, Qiang,Jia, Shu-Ting,Wang, Bo-Yuan,Zhang, Ji-Hong,Tang, Wen-Ru,Luo, Ying Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) has been associated with acute lymphoblastic leukemia (ALL). However, results were conflicting. The aim of this study was to quantitatively summarize the evidence for the MTHFRC677T polymorphism and ALL risk. Methods: Electronic searches of PubMed and the Chinese Biomedicine database were conducted to select case-control studies containing available genotype frequencies of C677T and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of any association. Results: Case-control studies including 6,371 cases and 10,850 controls were identified. The meta-analysis stratified by ethnicity showed that individuals with the homozygous TT genotype had decreased risk of ALL (OR= 0.776, 95% CI: 0.687~0.877, p< 0.001) in Caucasians (OR= 0.715, 95% CI: 0.655~0.781, p= 0.000). However, results among Asians (OR=0.711, 95% CI: 0.591~1.005, p= 0.055) and others (OR=0.913, 95% CI: 0.656~1.271, p= 0. 590) did not suggest an association. A symmetric funnel plot, the Egger's test (P=0.093), and the Begg- test (P=0.072) were all suggestive of the lack of publication bias. Conclusion: This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between the MTHFRC677T polymorphism and ALL.