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Park, Chihyun,Ahn, Jaegyoon,Yoon, Youngmi,Park, Sanghyun Oxford University Press 2012 Bioinformatics Vol.28 No.15
<P>Identifying functional relation of copy number variation regions (CNVRs) and gene is an essential process in understanding the impact of genotypic variations on phenotype. There have been many related works, but only a few attempts were made to normal populations.</P>
COMS-Based Retrieval of Daily Actual Evapotranspiration over Korea
Park, Na-Yeon,Jang, Jae-Dong,Kim, Youngmi,Sohn, Eun-Ha,Ou, Mi-Lim,Park, Jun-Dong,Seo, Minji,Lee, Kyeong-Sang,Han, Kyung-Soo Hindawi Limited 2017 Journal of sensors Vol.2017 No.-
<P>Evapotranspiration (ET) from the land surface is an important hydrometeorological factor in the exchange of energy between the atmosphere and land surface. The accurate quantification for management of water resources and understanding of climate change are crucial, requiring continuous temporal and spatial monitoring. The objective of this study is to apply and estimate daily actual ET using semiempirical method, B-method, which is based on surface energy balance over heterogeneous area, Korea. To estimate daily ET, we used geostationary meteorological satellite data (Communication, Ocean and Meteorological Satellite, COMS) and polar-orbiting satellite data (Système Pour ľObservation de la Terre, SPOT). Estimated daily ET using only satellite data was relatively accurate and reflects land surface characteristics. It had high periodicity and spatial resolution over a wide area on clear-sky days. The daily ET was overestimated by about 1 mm/day at the two flux tower measurements sites, but the simulated seasonal variation and pattern were in good agreement with flux tower measurements. In the mixed forest, the root-mean-square error (RMSE) was 0.94 mm/day and the bias was 1.05 mm/day, while, in the rice paddy, RMSE was 1.12 mm/day and bias was 1.21 mm/day.</P>
Role of short heterodimer partner as a novel coregulator between PPAR-γand NF-ĸB in atherogenesis
Park, Youngmi 이화여자대학교 세포신호전달연구센터 2003 고사리 세포신호전달 심포지움 Vol. No.5
Oxidized low-density lipoprotein(oxLDL) has been shown to modulate transactivations by the peroxisome proliferator activated receptor(PPAR)-γ and nuclear factor-kappa B(NF-ĸB). The oxLDL signaling pathways involved with the NF-ĸB transactivation were investigated by utilizing a reporter construct driven by three upstream NF-ĸB binding sites, and various pharmacological inhibitors. OxLDL and its constituent lysophophatidylcholine(lysoPC) induced a rapid and transient increase of intracellular calcium and stimulated the NF-ĸB transactivation in resting RAW264.7 macrophage cells in an oxidation-dependent manner. The NF-ĸB activation by oxLDL or lysoPC was inhibited by protein kinase C inhibitors or an intracellular calcium chelator. Tyrosine kinase or PI3 kinase inhibitors did not block the NF-ĸB transactivation. Furthermore, the oxLDL-induced NF-ĸB activity was abolished by the PPAR-γ ligands. When the endocytosis of oxLDL was blocked by cytochalasin B, the NF-ĸB transactivation by oxLDL was synergistically increased, while PPAR transactivation was blocked. These results suggest that oxLDL activates NF-ĸB in resting macrophages via protein kinase C- and/or calcium-dependent pathways, which does not involve the endocytic processing of oxLDL. The endocytosis-dependent PPAR-γ activation by oxLDL may function as an inactivation route of the oxLDL-induced NF-ĸB signal. Short heterodimer partner(SHP), specifically expressed in liver and a limited number of other tissues, is an unusual orphan nuclear receptor that lacks the conventional DNA-binding domain. We found that SHP expression is abundant in murine macrophage cell line RAW264.7 but suppressed by oxLDL and its constituent 13-HODE, a ligand for peroxisome proliferator-activated receptor γ. Furthermore, SHP acted as a transcription coactivator of nuclear factor kB(NF-ĸB) and was essential for the previously described NF-ĸB transactivation by lysoPC, one of the oxLDL constituents. Accordingly, NF-ĸB, transcriptionally active in the beginning, became progressively inert in oxLDL-treated RAW264.7 cells, as oxLDL decreased the SHP expression. Thus, SHP appears to be an important modulatory component to regulate the transcriptional activities of NF-ĸB in oxLDL-treated, resting macrophage cells.
Youngmi Park 한국섬유공학회 2020 Fibers and polymers Vol.21 No.4
Centella asiatica (CA) is known as a plant with therapeutic effect called Gotu Kola. In this study, silk was dyedusing undried raw CA (CA-R) and dried CA (CA-D) extracts; the samples were evaluated for properties such as dyeability;fastness to light, perspiration, and washing; antimicrobial properties; and ultraviolet (UV) protection. Before and afterdyeing, the sugar content and turbidity were measured to determine whether dyeing was efficient. It was confirmed that thedyeability and functionality of the CA-D-dyed samples were better than those of CA-R-dyed samples. For the fastness test,the fastness to light, at 4 or higher, was very good; furthermore, all the samples were in good condition for washing andperspiration, with grades ranging from 4 to 5. The UV-B protection value of the sample was 75 % higher than that of theundyed silk. The antimicrobial test showed that, in comparison to the original silk, silk dyed in the extracts exhibited 99.9 %better results, for concentrations above 5 μg/ml. Up to a concentration of 25 μg/ml, no significant decrease in cell viabilitywas noted, indicating that the antimicrobial activity of CA-R is excellent.
Role of DDX53 in taxol-resistance of cervix cancer cells in vitro
Park, Su Yeon,Kim, Won jin,Byun, Jae hwan,Lee, Jae Jun,Jeoung, Dooil,Park, Sung Taek,Kim, Youngmi Elsevier 2018 Biochemical and biophysical research communication Vol.506 No.3
<P><B>Abstract</B></P> <P>Cancer/Testis antigen DDX53 shows high expression level in various tumors and is involved in anti-cancer drug resistance. However, the functional study of DDX53 in cervix cancer remains unknown. In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated. In taxol-resistant Hela<SUP>TR</SUP> cells, DDX53 was significantly increased as compared to the parental HeLa cells. Hela<SUP>TR</SUP> cells also showed upregulation of multidrug resistant gene MDR1, invasive characteristics and decreased apoptosis. In addition, increased autophagy level was observed in Hela<SUP>TR</SUP> cells. Overexpression of DDX53 in HeLa and SiHa markedly led to greater resistance to taxol and cisplatin, whereas knockdown of DDX53 in Hela<SUP>TR</SUP> cells restored sensitivity, demonstrating that DDX53 regulated taxol resistance in cervix cancer cells. DDX53 overexpression in HeLa and SiHa cells enhanced invasion, migration and anchorage independent growth, DDX53 knockdown showed inverse effects in HeLa<SUP>TR</SUP> cells. When DDX53 expression was suppressed by siRNA, autophagic flux and drug resistance of Hela<SUP>TR</SUP> cells were decreased. In addition, DDX53 was upregulated in cervix cancer tissues from patient with a glassy cell carcinoma of cervix. Taken together, these results suggest that DDX53 plays a critical role in taxol-resistance by activating autophagy and a potential therapeutic target for the treatment of taxol-resistant cervix cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> DDX53 is upregulated in taxol-resistance HeLa<SUP>TR</SUP> cervix cancer cells. </LI> <LI> DDX53 increases the invasion, migration and colony formation of HeLa<SUP>TR</SUP> cervix cancer cells. </LI> <LI> The downregulation of DDX53 contributes to the anti-cancer drug sensitivity of HeLa<SUP>TR</SUP> cervix cancer cells. </LI> <LI> DDX53 confers the anti-cancer drug resistance via activation of autophagy in HeLa<SUP>TR</SUP> cervix cancer cells. </LI> <LI> DDX53 is upregulated in cancer tissue and tissue-derived cancer cell from patient with glassy cell carcinoma of cervix. </LI> </UL> </P>
Park, Youngmi,Nam, Keumhee,Bae, Joohee Korean Society for Hospice and Palliative Care 2021 한국호스피스.완화의료학회지 Vol.24 No.1
Purpose: This study examined the relationship between Knowledge of Life-sustaining Treatment Plans and Attitudes toward Withdrawal of Life-sustaining Treatment among nursing college students, and attempted to identify the mediating effect of Role Perception on Life-sustaining Treatment in that relationship. It is hoped that the findings will ultimately contribute to the development of active nursing strategies. Methods: The participants were 142 nursing college students in the third and fourth years of study who had experienced clinical practice at two universities in cities Y and C. Data were collected from November 1 to 30, 2019. For data analysis, SPSS for Windows version 22.0 was used to calculate descriptive statistics, the t-test, Pearson's correlation coefficients, and multiple regression. To analyze the mediating effect, the Baron and Kenny bootstrapping method was used. Results: Attitudes toward Withdrawal of Life-sustaining Treatment of nursing college students had a significant positive correlation with Knowledge of Life-sustaining Treatment Plans (r=0.34, P<0.001) and Role Perception on Life-sustaining Treatment (r=0.44, P<0.001). Role Perception on Life-sustaining Treatment partially mediated the relationship between Knowledge of Life-sustaining Treatment Plans and Attitudes toward Withdrawal of Life-sustaining Treatment (95% CI, 0.446~1.055). Conclusion: Based on the results of this study, improving nursing college students' Role Perception on Life-sustaining Treatment could be used as a coping strategy to establish positive Attitudes toward Withdrawal of Life-sustaining Treatment.
Park, Seung-Yoon,Choi, Jung Hyun,Ryu, Hyun Su,Pak, Youngmi Kim,Park, Kyong Soo,Lee, Hong Kyu,Lee, Wan American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.41
<P>Depletion of mtDNA in myocytes causes insulin resistance and alters nuclear gene expression that may be involved in rescuing processes against cellular stress. Here we show that the expression of C1q tumor necrosis factor alpha-related protein isoform 5 (C1QTNF5) is drastically increased following depletion of mtDNA in myocytes. C1QTNF5 is homologous to adiponectin in respect to domain structure, and its expression and secretion from myocytes correlated negatively with the cellular mtDNA content. Similar to adiponectin, C1QTNF5 induced the phosphorylation of AMP-activated protein kinase (AMPK), leading to increased cell surface recruitment of GLUT4 and increased glucose uptake. Treatment of cells with purified recombinant C1QTNF5 increased the phosphorylation of acetyl-CoA carboxylase and stimulated fatty acid oxidation. C1QTNF5-mediated phosphorylation of AMPK or acetyl-CoA carboxylase was unaffected by depletion of adiponectin receptors such as AdipoR1 or AdipoR2, which indicated that adiponectin receptors do not participate in C1QTNF5-induced activation of AMPK. Serum C1QTNF5 levels were significantly higher in obese/diabetic animals (OLETF rats, ob/ob mice, and db/db mice). These results highlight C1QTNF5 as a putative biomarker for mitochondrial dysfunction and a potent activator of AMPK.</P>