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Anxiolytic-like effects of sinapic acid in mice
Yoon, Byung Hoon,Jung, Ji Wook,Lee, Jong-Ju,Cho, Young-Wuk,Jang, Choon-Gon,Jin, Changbae,Oh, Tae Hwan,Ryu, Jong Hoon WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Sinapic acid is a phenylpropanoid compound and is found in various herbal materials and high-bran cereals. With the exception of its anlioxidant activities, the pharmacological properties of sinapic acid have been rarely reported. The purpose of this study was to characterize the putative anxiolytic-like properties of sinapic acid using an elevated plus-maze (EPM) and hole-board test. Conlrol mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). Sinapic acid (4 ing/kg, P.o.) significantly increased the percentages of time spent in the open arms of the EPM test (P<0.05). In the hole-board test, sinapic acid also significantly increased the number ot head-dips at 4 mg/kg (P<0.05). In addition, the anxiotytic-like properties of sinapic acid examined in the EPM test were blocked by flumazenil or bicuculline, which are GABA_(A) antagonists. Moreover, sinapic acid markedly potentiated GABA current in single cortical neurons in a dose-dependant manner, and reactive I_(GABA) increased to 1.8 times at 1 μM of sinapic acid. These results suggested that sinapic acid is a prominent anxiolytic agent, and that its anxiolytic-like effects are mediated via GABA_(A) receptors and potentiating CI currents.
Yoon, Ho Joon,Cheon No, Hee,Kim, Young Soo,Jin, Hyung Gon,Lee, Jeong-Ik,Lee, Byung Jin Elsevier 2009 International journal of hydrogen energy Vol.34 No.19
<P><B>Abstract</B></P><P>Conventional I–S cycle flowsheets suffer from low thermal efficiency and highly corrosive streams. To alleviate these problems, KAIST has proposed the optimal operating condition for the Bunsen reaction and devised a new flowsheet that produces highly enriched HI through spontaneous L–L phase separation and simple flash processes under low pressure. A series of experiments were performed at KAIST to validate the new flowsheet and extend its feasibility. The experimental procedure, measurement method with a rich iodine condition, and results of experiments are discussed in this paper. When the molar ratio of I<SUB>2</SUB>/H<SUB>2</SUB>SO<SUB>4</SUB> in the feed increased from 2 to 4, the molar ratio of HI/(HI+H<SUB>2</SUB>O) in the HIx phase improved from 0.157 to 0.22, which is high enough to generate highly enriched HI gas through flashing. An inverse Bunsen reaction and a sulfur formation were observed when the temperature was increased from 313K to 343K and the molar ratio of I<SUB>2</SUB>/H<SUB>2</SUB>SO<SUB>4</SUB> was decreased from 4 to 1. 10–50wt% of HI in the feed turned into I<SUB>2</SUB> when an inverse Bunsen reaction and a sulfur formation occurred. The experimental data utilized in the previous parametric study of KAIST has been validated.</P>
Development of screening method for highly enriched peptides toward a multiple LPS using epoxy bead
Yun-Gon Kim(김윤곤),Chang-Soo Lee(이창수),Woo-Jae Chung(정우재),Eun-Mi Kim(김은미),Dong-Sik Shin(신동식),June-Hyung Kim(김준형),Yoon-Sik Lee(이윤식),Junho Chung(정준호),Byung-Gee Kim(김병기) 한국생물공학회 2005 한국생물공학회 학술대회 Vol.2005 No.10
Kim, Yoon-Woo,Sung, Changmin,Lee, Seulee,Kim, Kyoung-Jin,Yang, Yung-Hun,Kim, Byung-Gee,Lee, Yoo Kyung,Ryu, Hee Wook,Kim, Yun-Gon American Chemical Society 2015 ANALYTICAL CHEMISTRY - Vol.87 No.2
<P><I>N</I>-Acyl homoserine lactones (AHLs), quorum sensing molecules produced by Gram-negative bacteria, are used as important secondary metabolites for antibacterial drug development and cell-to-cell communication. Although various analytical techniques have been developed for detection and quantitation of AHLs from more complex bacterial culture media, only a few methods have been applied to AHL identification in physiological samples. Here, we developed a highly sensitive and reliable MALDI-based 3-oxo AHL quantitation method by employing Girard’s reagent T (GT) to produce a permanent cationic charge state [M]<SUP>+</SUP> at the ketone group of AHLs. After extracting AHLs from the supernatant of bacterial cultures using ethyl acetate, the extracts were subsequently derivatized with GT without any additional purification or desalting steps. The chemical derivatization of 3-oxo AHLs dramatically enhanced sensitivity (up to 60 000 times) by lowering the limit of detection (LOD, ∼0.5 fmol)/limit of quantitation (LOQ, ∼2.5 fmol). Additionally, the GT-derivatized 3-oxo AHLs allowed more accurate quantitative analysis from the <I>Pseudomonas aeruginosa</I> PAO1 culture supernatants. This method may be applied for developing high-throughput and sensitive detection methods of quorum sensing signal molecules in biofilm-related clinical applications such as virulence factor characterization and antibacterial drug development.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2015/ancham.2015.87.issue-2/ac5039362/production/images/medium/ac-2014-039362_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac5039362'>ACS Electronic Supporting Info</A></P>
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김병곤(Byung-Gon Kim),이병길(Byeong-Gil Lee),윤일기(Il-Ki Yoon) 한국데이타베이스학회 2020 Journal of information technology applications & m Vol.27 No.3
Recently, following the development of FinTech technology that combines finance and information and communication technology, the need and social demands for a block chain technology-based trading system have increased significantly. In this study, a research model was developed and hypothesized through literature research on the concept of block chain technology, the technology acceptance model, and the unified theory of acceptance and use of technology. The research theories were tested by collecting data through surveys and analyzing the collected data. This study conducted empirical research to identify the factors influencing the user acceptance intention and utilization behavior of the block chain technology in introducing the block chain technology. First, factors affecting the acceptance intention of the blockchain user were performance expectation, effort expectation, social impact, and blockchain transparency variables. Second, the facilitation conditions and stakeholder confidence variables were analyzed as factors that did not affect the acceptability of the blockchain users. Third, variables such as blockchain transparency, stakeholder trust and intention of acceptance are factors that affect the usage behavior of the blockchain. Fourth, it was confirmed that the acceptance intention had a very high explanatory power on usage behavior of Blockchain technology.