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Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson’s disease
Eun-Joo Shin,정지훈,Yeonggwang Hwang,Naveen Sharma,Duy-Khanh Dang,Bao-Trong Nguyen,나승열,Choon-Gon Jang,Guoying Bing,Toshitaka Nabeshima,Hyoung-Chun Kim 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
Parkinson’s disease (PD) is a progressive neurodegenerativedisease with a high prevalence, approximately1 % in the elderly population. Numerous studies have demonstratedthat methamphetamine (MA) intoxication causedthe neurological defi cits and nigrostriatal damage seen inParkinsonian conditions, and subsequent rodent studies havefound that neurotoxic binge administration of MA reproducedPD-like features, in terms of its symptomatology andpathology. Several anti-Parkinsonian medications have beenshown to attenuate the motor impairments and dopaminergicdamage induced by MA. In addition, it has been recognized that mitochondrial dysfunction, oxidative stress, pro-apoptosis,proteasomal/autophagic impairment, and neuroinfl ammationplay important roles in inducing MA neurotoxicity. Importantly, MA neurotoxicity has been shown to share acommon mechanism of dopaminergic toxicity with that ofPD pathogenesis. This review describes the major fi ndingson the neuropathological features and underlying neurotoxicmechanisms induced by MA and compares them with Parkinsonianpathogenesis. Taken together, it is suggested thatneurotoxic binge-type administration of MA in rodents is avalid animal model for PD that may provide knowledge onthe neuropathogenesis of PD.
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