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고속 전철 Catenary/Pantograph계의 동특성 해석
최연선,정대현 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2
The vibrations in Catenary/Pantograph system should be avoided to assure the power collection in High-Speed train. Contacts between pantograph and trolley wire depend on various design parameters. To select good design parameters, analytical and numerical simulation were performed for a simplified model. The dynamic characteristics of tensioned wire subject to moving force was calculated using Laplace transform. And, a simulation program was developed to calculate the displacement of trolley wire using Euler method. The numerical results showed good agreements between two methods.
고속전철 Catenary/Pantograph계의 동적응답에 대한 수치해석
최연선,정대현 成均館大學校 科學技術硏究所 1991 論文集 Vol.42 No.1
To increase the velocity of high speed train, electric power collection through pantograph from trolley wire of should be guaranted. As the velocity increase, there are lots of possibility of separation between pantograph and trolley wire due to the mutual dynamic behaviors. However, the complexity of actual Catenary system makes almost impossible to find dynamic responses analytically. In this respect a numerical method is developed to calculate the dynamic responses of Catenary/Pantograph system using central difference method. And the dynamic characteristics of Catenary/Pantograph are investigated as the design parameter variation.
FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과
최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1
Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.
Superficial CD34+ fibroblastic tumor on the plantar foot
( Hyeon Jeong Park ),( Kyu Yeon Kim ),( Bo Bin Cha ),( Jin Seop Kim ),( Yeon Gu Choi ),( Gyoo Huh ),( Heun Joo Lee ),( Young Jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Fibroblastic mesenchymal tumors show a spectrum of biological behavior, from benign to malignant. We here in report our experience of a distinctive features of superficial CD34-positive fibroblastic tumor (SCPFT), which is a newly described neoplasm, previously undescribed low-grade fibroblastic tumor of the superficial soft tissues. A 45-year-old man presented with subcutaneous nodular lesion on the mid foot area of the right sole. The lesion was near the area of skin graft of the foot, which undergone traumatic amputation by traffic accident 40 years ago. The right foot MR examination revealed 2.0x1.6x0.8 cm sized enhancing mass involving skin and subcutaneous layer. After total excision with supralesional flap surgery, the histopathological study of the 1.9x1.8x0.5 cm sized mass revealed some nodular growing pattern of atypical spindle cell proliferative lesion with distinctive angiomatosis, moderate nuclear atypia, admixed some inflammatory cells in fibro-fatty tissue, and mitotic figures of 1/10 HPFs. The CD34 stain showed diffusely positive reaction for the lesion, and the expression of Ki-67 protein was very low. Finally, the patient was diagnosed with SCPFT. To date, 42 cases of SCPFT have been reported. The incidence rate of this entity is much higher due to the lack of sufficient recognition of this tumor. Herein, we report a rare case of the SCPFT to enhance the recognition and diagnostic level of the disease.
A retrospective analysis of factors affecting effectiveness of cyclosporine in psoriatic patients
( Yeon Gu Choi ),( Jin Seop Kim ),( Gyoo Huh ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yunho Lee ),( Heun Joo Lee ),( Young-jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Cyclosporine is an effective drug for the treatment of psoriasis. Nonetheless, little is known about factors associated with effectiveness of cyclosporine. Objectives: To analyze factors affecting effectiveness of cyclosporine in psoriatic patients. Methods: ‘Good response to treatment’ and ‘treatment failure’ were each defined as who has been achieved 75% improvement in the psoriasis area and severity index (PASI 75) and who has not been achieved PASI 50. The factors affecting good response to treatment were investigated by comparing good response group and the others. Additionally, we analyzed factors affecting treatment failure and the time to achieve PASI 75. Results: Patients 78(63 males and 13 females, mean age 44.9 ± 13.1 years) were analyzed. Baseline PASI score, staring dose, treatment duration, age of onset, accompanying psoriatic arthritis showed a significant relation with PASI 75 achievement. And starting dose, last dose, age of onset showed relation with PASI 50 achievement. The mean time of achieving PASI 75 was 6.70 ± 3.17 weeks and didn’t correlate with any factor. Conclusion: High starting dose, sufficient treatment duration may be considered for successful cyclosporine treatment in psoriatic patients, especially in severe severity, long disease-duration or psoriatic arthritis patient. Also, high starting dose and proper dosage increment may be need for prevention of treatment failure, particularly in long disease-duration patients.
Choi, Yeon Ah,Yoon, You Hyun,Choi, Kwangik,Kwon, Mihwa,Goo, Soo Hyeon,Cha, Jin-Sun,Choi, Min-Koo,Lee, Hye Suk,Song, Im-Sook Pharmaceutical Society of Japan 2015 Biological & pharmaceutical bulletin Vol.38 No.2
<P>To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, size distribution, drug encapsulation efficiency, and percent drug loading of the formulation were characterized. Subsequently, in vivo pharmacokinetic parameters of morin loaded in a PluronicF127 and Tween80 mixed-micelle formulation were investigated in rats. Absolute bioavailability of morin was dramatically increased by the oral administration of morin-loaded PluronicF127 and Tween80 mixed micelle from 0.4% to 11.2% without changing the systemic clearance and half-life. In Caco-2 cells, absorption permeability of morin from the novel formulation was increased 3.6-fold compared with that of morin alone. P-gp inhibition by cyclosporine A (CsA) increased absorptive permeability of morin 2.4-fold but decreased the efflux of morin by 52%, which was consistent with increased plasma concentration of morin in the pretreatment of CsA in rats. The morin formulation inhibited P-gp transport activity by 83.1% at 100 ?M as morin concentration. Moreover, morin formulation increased paracellular permeability of Lucifer yellow by 1.6-1.8 fold. In conclusion, enhanced oral bioavailability of morin from morin-loaded PluronicF127 and Tween80 mixed micelle formulation can be attributed to increased intestinal permeation of morin, which was mediated at least by P-gp inhibition and enhanced paracellular route.</P>