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Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Yeo, Seung-Geun,Cha, Chang-Il,Park, Dong-Choon The Korean Association of Immunobiologists 2006 Immune Network Vol.6 No.1
Background: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small pro portion of splenic B cells and they are larger and less dense than B-2 cells in morphology. This study was designed to compare the differences in their proliferation and differentiation between B-1 and B-2 cell. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. Secreted IgM was measured by enzyme-linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Cell cycle analysis by propidium iodide was performed. p21 expression was assessed by real time PCR. Results: Cell proliferation and cell cycle progression in B-1 and B-2 cells, which did not occur in the absence of LPS, required LPS stimulation. After LPS stimulation, B-1 and B-2 cells were shifted to Sand G2/M phases. p21 expression by resting B-1 cells was higher than that of resting B-2 cells. Conclusion: B-1 cells differ from conventional B-2 cells in proliferation, differentiation and cell cycle.
Cha, Chang-Il,Lee, Young-Chan,Park, Dong-Choon,Kim, Young-Il,Lee, Jin-Woo,Yeo, Seung-Geun The Korean Association of Immunobiologists 2008 Immune Network Vol.8 No.2
Background: Toll-like receptors (TLRs) detect microbial infection and can directly induce innate host defense responses, which are thought to play critical roles in protecting the tubotympanum from infection. However, little is known about the relationship between TLRs, which are related to innate immunity, and immunoglobulins, which are related to adaptive immunity, in recurrent otitis media with effusion (OME). We therefore investigated the expression of TLR2 and TLR4 and immunoglobulin in children with OME. Methods: The study population consisted of 72 children with OME, 31 with more than 4 episodes in 12 months or more than 3 episodes in 6 months (otitis-prone group), and 41 with fewer than 3 episodes in 12 months (non-otitis prone group). The expression in middle ear effusion of TLR2 and TLR4 mRNA, as determined by Real time- -polymerase chain reaction (RT-PCR), and the concentrations of IgG, IgA, and IgM, as determined by Enzyme-linked immunosorbent assay(ELISA), were compared between the two groups. Results: Expression of TLR2 and TLR4 mRNA was lower in the otitis prone than in the non-otitis prone group, but the difference was not statistically significant (p>0.05). Between group differences in the concentrations of IgG, IgA and IgM in effusion fluid were not significant (p>0.05), and there were no correlations between immunoglobulin concentration and the expression of TLR2 and TLR4. Conclusion: Although there was a trend toward lower expression of TLR2 and TLR4 in the otitis-prone group, the differences, and those in immunoglobulin concentration, did not differ significantly between the otitis-prone and non-prone groups.
Bacteriology of chronic suppurative otitis media : a multicenter study
YEO, SEUNG GEUN,PARK, DONG CHOON,HONG, SEOK MIN,CHA, CHANG IL,KIM, MYUNG GU WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Conclusions. Bacterial predominance and antibiotic sensitivity have changed over time, making continuous and periodic surveillance necessary in guiding appropriate antibacterial therapy. Objectives. With the development and widespread use of antibiotics, the types of pathogenic microorganisms and their resistance to antibiotics have changed. Knowledge of the species and resistance rates of current pathogens is important for determining the appropriate antibiotics for patients with chronic suppurative otitis media. We investigated the current bacteriology of chronic suppurative otitis media. Subjects and methods. This was a retrospective study of 1102 patients with chronic suppurative otitis media seen at six hospitals in Korea from January 2001 to December 2005. Results. The most commonly identified pathogenic bacterial species was Pseudomonas, with the next most prevalent being methicillin-resistant Staphylococcus aureus (MRSA).
Isolated intracranial fibromuscular dysplasia of the posterior cerebral artery
Yeo, Min-Ju,Jeon, Ho-Yeong,Cha, Min-Ju,Jang, Hye-Yeon,Lee, Sang-Gil,Seon Kim, Ji,Lee, Sung-Hyun,Lee, Sang-Soo,Shin, Dong-Ick Elsevier 2017 JOURNAL OF CLINICAL NEUROSCIENCE Vol.43 No.-
<P><B>Abstract</B></P> <P>Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory arterial disease that most commonly affects the renal and internal carotid arteries, but intracranial FMD is very rare. We report a patient with FMD involving the posterior cerebral arteries (PCAs). A 24year old female was presented with a 4day history of right homonymous hemianopsia with throbbing headache in the left temporo-occipital area. The brain magnetic resonance imaging (MRI) revealed an acute ischemic stroke in the left PCA territory, while the Time of Flight (TOF) magnetic resonance angiogram (MRA) showed segmental luminal irregularities in the left proximal PCA. The conventional angiogram revealed the “string of beads” appearance, a characteristic that is pathognomonic for FMD. The patient’s inhospital clinical course was stable, while there was no recurrence of stroke. This is the second report of FMD of the PCA. Notwithstanding incredibly rare incidences of isolated intracranial FMD and nonspecific findings of MRA, such a pathophysiology should be considered as the cause for a stroke in young patients, especially those with no cardiovascular risk factor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Isolated intracranial FMD with the “string of beads” appearance is very rare. </LI> <LI> In young patients without the risk of atherosclerosis, intracranial FMD should be considered as a pathophysiology of stroke. </LI> <LI> TOF-MRA may show unclear “string of beads” appearance such as segmental luminal irregularities in intracranial FMD. </LI> </UL> </P>
Yeo, Seung Geun,Park, Dong Choon,Eun, Young Gyu,Cha, Chang Il WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Purpose: The pathogenesis of otitis media with effusion(OME) is considered multifactorial, with viral upper respiratory tract infection and eustachian tube dysfunction. Allergy may be related to the pathogenesis of OME or to another etiological factor. We investigated the role of allergic rhinitis(AR) in children with OME and evaluated eustachian tube function in patients with AR. Materials and methods: We prospectively analyzed the prevalence of AR. serum eosinophil count and serum total IgE concentrations in 123 children with OME and in 141 controls. IgE concentration in middle ear effusion was compared in children with OME with and without AR, and eustachian tube function after a nasal provocation test was compared between patients with AR and controls. Results: The prevalence of AR in children with OME (28.4%) and control subjects (24.1 %) did not differ significantly. These 2 groups also showed no differences in total eosinophil count and serum and middle car effusion IgE concentration. Abnormalities in eustachian tube function were the same in patients with AR and controls. Conclusions: Allergic rhinitis may not be related to the development of OME in children.
증례 : 알레르기 ; Visipaque(R) 조영제 사용 후 발생한 후기 부작용 1예
김차영 ( Cha Young Kim ),김희진 ( Hee Jin Kim ),김문진 ( Moon Jin Kim ),강여진 ( Yeo Jin Kang ),김현정 ( Hyun Jung Kim ),장세호 ( Se Ho Chang ),박동준 ( Dong Jun Park ) 대한내과학회 2011 대한내과학회지 Vol.81 No.1
저자들은 신 증후군 환자에서 Visipaque(R) 사용 후 발생한 후기 지연 부작용을 경험하였고, 이를 문헌고찰과 함께 보고 하는 바이다. Late adverse reactions to iodinated contrast medium are defined as reactions occurring 1 hour to 1 week after contrast medium injection. The majority of late adverse reactions are cutaneous reactions, and include itching, maculopapular rash, urticaria, erythematous patches, and angioedema. We report a patient with an iodixanol (Visipaque(R))-induced late adverse reaction. She was admitted for evaluation of nephrotic range proteinuria and edema. Abdomen and chest enhanced computed tomography was performed as a malignancy work-up. Sixteen hours after radiocontrast exposure, her entire body felt itchy. A maculopapular rash was first detected on her back and abdomen 24 hours after exposure, and spread over her entire body, including her face. Her skin lesions resolved completely in 5 days after administering steroid and antihistamine. We should consider late adverse reactions of iodinated contrast medium when we detect skin lesions late after radiocontrast use. (Korean J Med 2011;81:130-134)
주거건물의 기능성 부속기기 일체화 급수ㆍ급탕 헤더시스템 성능 평가에 관한 연구
차민철(Cha Min-Chul),김동우(Kim Dong-Woo),여명석(Yeo Myoung-Souk),석호태(Seok Ho-Tae) 대한건축학회 2007 대한건축학회논문집 Vol.23 No.10
In this study, the performance evaluations are conducted under the condition of composition ratio by 1:1 between individual hot water supply system accounting for 59.4% of the entire apartment and cold & hot water supply manifold system using functionally complex valves such as water hammer arrester, constant flow regulating valve and 3-way mixing valve in the 30 py apartment which consist of the largest part of the whole apartment. Also, water hammering caused by opening or closing the faucet, flow rate related to simultaneous use of faucets and change of hot water temperature are compared with the existing method. These are to show the possibility of improving performance of cold and hot water supply system. The results are as follows. It is indicated that the result given by installing water hammer arrester into both main header and sub header is similar to that of the end of pipe and faucet. And reduction of flow rate is considered the lowest in the method of manifold system through integration of functional valves of open type of faucets I~II. The result shows that the effect of integration functional header system could be improved providing water pressure is beyond 2.5kg/cm2 in open type of faucet I and water heater allowing hot water to be used in at the latest 2 faucets is installed.