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        Haemaphysalis concinna (Acari: Ixodida): Persistent efficacy of doramectin in rabbits under laboratory conditions

        Yao BIAN,Guangyou YANG,Tao WANG,Huijuan YAN,Shuai WANG,Jiagang SUN,Kaijun LI 한국곤충학회 2009 Entomological Research Vol.39 No.2

        In the present study, the persistent efficacy of doramectin (DOR) in rabbits infested by Haemaphysalis concinna was observed. DOR (200 µg/kg) was administered once to infested rabbits by subcutaneous injection. A total of 15 rabbits were allocated to three groups, which were observed for efficacy. On days 1–7, 8–14, 15–21 and 22–28 post-inoculation, the percent reduction of tick larvae in DOR treated rabbits was 100.0, 100.0, 86.7 and 61.7%, respectively; the percent reduction of nymphs was 100.0, 90.0, 75.0 and 65.0%, respectively; and the percent reduction of adults was 85.0, 65.0, 55.0 and 55.0%, respectively. In comparison, in untreated rabbits at the same time points (control group), the percent reduction of larvae was 5.0, 3.3, 5.0 and 5.0%, respectively, and there was no reduction of nymphs and adults in the untreated rabbits.

      • Development and Evaluation of a Patient-Reported Outcome (PRO) Scale for Breast Cancer

        Zhang, Jun,Yao, Yu-Feng,Zha, Xiao-Ming,Pan, Li-Qun,Bian, Wei-He,Tang, Jin Hai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

        Background: This study was guided by principles of the theoretical system of evidence-based medicine. In particular, when searching for evidence of breast cancer, a measuring scale is an instrument for evaluating curative effects in accordance with the laws and characteristics of medicine and exploring the establishment of a system for medically assessing curative effects. At present, there exist few tools for evaluating curative effects. Patient-reported outcomes (PROs) refer to outcomes directly reported by patients (without input or explanations from doctors or other intermediaries) with respect to all aspects of their health. Data obtained from PROs provide evidence of treatment effects. Materials and Methods: In accordance with the tenets of theoretical medicine and ancient medical theory regarding breast cancer, principles for developing a PRO scale were established, and a theoretical model was developed and a literature review was performed, items from this pool were combined and split, and an initial scale was constructed. After a pilot survey and additional modifications, a pre-questionnaire scale was formed and used in a field investigation. After the application of statistical methods, the item pool was used to create a formal scale. The reliability, validity and feasibility of this formal scale were then assessed. Results: In a clinical investigation, 479 responses were recovered, with an acceptance rate of 95%. a combination of various methods was employed, and the items that were selected by all methods or more than half of the methods were employed in the questionnaire. In these cases, the screening methods were combined with certain features of the item, A total of four domains and 38 items were reserved. The reliability analysis indicated that the PRO scale was relatively reliable. Conclusions: Scientific assessment proved that the proposed scale exhibited good reliability and validity. This scale was readily accepted and could be used to assess the curative effects of medical therapy. However, given the limited scope of this investigation, the capacity for adapting this scale to incorporate other theories could not be determined.

      • SCIESCOPUSKCI등재

        Design of a High-Precision Constant Current AC-DC Converter with Inductance Compensation

        Chang, Changyuan,Xu, Yang,Bian, Bin,Chen, Yao,Hu, Junjie The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

        A primary-side regulation AC-DC converter operating in the PFM (Pulse Frequency Modulation) mode with a high precision output current is designed, which applies a novel inductance compensation technique to improve the precision of the output current, which reduces the bad impact of the large tolerance of the transformer primary side inductance in the same batch. In this paper, the output current is regulated by the OSC charging current, which is controlled by a CC (constant current) controller. Meanwhile, for different primary inductors, the inductance compensation module adjusts the OSC charging current finely to improve the accuracy of the output current. The operation principle and design of the CC controller and the inductance compensation module are analyzed and illustrated herein. The control chip is implemented based on a TSMC 0.35μm 5V/40V BCD process, and a 12V/1.1A prototype has been built to verify the proposed control method. The deviation of the output current is within ±3% and the variation of the output current is less than 1% when the inductances of the primary windings vary by 10%.

      • KCI등재

        Design of a High-Precision Constant Current AC-DC Converter with Inductance Compensation

        Changyuan Chang,Yang Xu,Bin Bian,Yao Chen,Junjie Hu 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

        A primary-side regulation AC-DC converter operating in the PFM (Pulse Frequency Modulation) mode with a high precision output current is designed, which applies a novel inductance compensation technique to improve the precision of the output current, which reduces the bad impact of the large tolerance of the transformer primary side inductance in the same batch. In this paper, the output current is regulated by the OSC charging current, which is controlled by a CC (constant current) controller. Meanwhile, for different primary inductors, the inductance compensation module adjusts the OSC charging current finely to improve the accuracy of the output current. The operation principle and design of the CC controller and the inductance compensation module are analyzed and illustrated herein. The control chip is implemented based on a TSMC 0.35μm 5V/40V BCD process, and a 12V/1.1A prototype has been built to verify the proposed control method. The deviation of the output current is within ±3% and the variation of the output current is less than 1% when the inductances of the primary windings vary by 10%.

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