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      • Enhancement of photoacoustic image quality by sound speed correction: ex vivo evaluation.

        Yoon, Changhan,Kang, Jeeun,Han, Seunghee,Yoo, Yangmo,Song, Tai-Kyong,Chang, Jin Ho Optical Society of America 2012 Optics express Vol.20 No.3

        <P>Real-time photoacoustic (PA) imaging involves beamforming methods using an assumed fixed sound speed, typically 1540 m/s in soft tissue. This leads to degradation of PA image quality because the true sound speed changes as PA signal propagates through different types of soft tissues: the range from 1450 m/s to 1600 m/s. This paper proposes a new method for estimating an optimal sound speed to enhance the cross-sectional PA image quality. The optimal sound speed is determined when coherent factor with the sound speed is maximized. The proposed method was validated through simulation and ex vivo experiments with microcalcification-contained breast cancer specimen. The experimental results demonstrated that the best lateral resolution of PA images of microcalcifications can be achieved when the optimal sound speed is utilized.</P>

      • Vein Visualization Using a Smart Phone With Multispectral Wiener Estimation for Point-of-Care Applications

        Song, Jae Hee,Kim, Choye,Yoo, Yangmo IEEE 2015 IEEE Journal of Biomedical and Health Informatics Vol.19 No.2

        <P>Effective vein visualization is clinically important for various point-of-care applications, such as needle insertion. It can be achieved by utilizing ultrasound imaging or by applying infrared laser excitation and monitoring its absorption. However, while these approaches can be used for vein visualization, they are not suitable for point-of-care applications because of their cost, time, and accessibility. In this paper, a new vein visualization method based on multispectral Wiener estimation is proposed and its real-time implementation on a smart phone is presented. In the proposed method, a conventional RGB camera on a commercial smart phone (i.e., Galaxy Note 2, Samsung Electronics Inc., Suwon, Korea) is used to acquire reflectance information from veins. Wiener estimation is then applied to extract the multispectral information from the veins. To evaluate the performance of the proposed method, an experiment was conducted using a color calibration chart (ColorChecker Classic, X-rite, Grand Rapids, MI, USA) and an average root-mean-square error of 12.0% was obtained. In addition, an <I>in vivo</I> subcutaneous vein imaging experiment was performed to explore the clinical performance of the smart phone-based Wiener estimation. From the <I>in vivo</I> experiment, the veins at various sites were successfully localized using the reconstructed multispectral images and these results were confirmed by ultrasound B-mode and color Doppler images. These results indicate that the presented multispectral Wiener estimation method can be used for visualizing veins using a commercial smart phone for point-of-care applications (e.g., vein puncture guidance).</P>

      • Optimal sound speed estimation using modified nonlinear anisotropic diffusion to improve spatial resolution in ultrasound imaging

        Changhan Yoon,Haijin Seo,Yuhwa Lee,Yangmo Yoo,Tai-Kyong Song,Jin Ho Chang IEEE 2012 and Frequency Control Vol.59 No.5

        <P>In ultrasound exams of obese patients and the breast, the spatial and contrast resolutions of ultrasound images are severely deteriorated when a constant sound speed corresponding to soft tissue is used in receive dynamic beamformation. This degradation is due to the defocusing of the ultrasound beam because of the disparity in sound speed between soft tissue and fatty layers. To minimize the degradation, this paper proposes a new method of estimating an optimal sound speed that can be used to achieve the best beamforming performance in a region of interest (ROI). The proposed method employs a new focusing quality factor (FQF) as an indicator of how well the focusing is conducted with a given sound speed. The FQF is closely associated with the degree of edge conspicuity, which can be obtained using the proposed modified nonlinear anisotropic diffusion (MNAD) technique. To calculate FQF, ultrasound images are formed with different sound speeds ranging from 1400 to 1600 m/s and, subsequently, the ROI is chosen. In the ROI, the degrees of edge conspicuity (i.e., FQF) are calculated. The sound speed can be considered an optimal one for the ROI if it is used to construct the image that provides the maximum FQF. The performances of the proposed method were evaluated through simulation and in vitro experiments with a tissue-mimicking phantom. The performance was also compared with that of the conventional image-based method employed in a commercial ultrasound imaging system. The experimental results demonstrated that the proposed method is capable of estimating an optimal sound speed with an error of 10 m/s regardless of whether strong targets are included in the ROI or not. On the other hand, the conventional image-based method generated an estimation error of 60 m/s maximally in the case in which there were no strong targets in ROI. This indicates that the proposed method is a useful tool to improve ultrasound image quality for clinical applications, especially for ultrasound exams of obese patients and the breast.</P>

      • A New Dynamic Complex Baseband Pulse Compression Method for Chirp-Coded Excitation in Medical Ultrasound Imaging

        Jinbum Kang,Yeajin Kim,Wooyoul Lee,Yangmo Yoo IEEE 2017 and Frequency Control Vol.64 No.11

        <P>Chirp-coded excitation can increase the signal-to-noise ratio (SNR) without degrading the axial resolution. Effective pulse compression (PC) is important to maintain the axial resolution and can be achieved with radio frequency (RF) and complex baseband (CBB) data (i.e., PCRF and PCCBB, respectively). PCCBB can further reduce the computational complexity compared to PCRF; however, PCCBB suffers from a degraded SNR due to tissue attenuation. In this paper, we propose a new dynamic CBB PC method (PCCBB-Dynamic) that can improve the SNR while compensating for tissue attenuation. The compression filter coefficients in the PCCBB-Dynamic method are generated by dynamically changing the demodulation frequencies along with the depth. For PC, the obtained PCCBB-Dynamic coefficients are independently applied to the in-phase and quadrature components of the CBB data. To evaluate the performance of the proposed method, simulation, phantom, and in vivo studies were conducted, and all three studies showed improved SNR, i.e., maximally 3.87, 7.41, and 5.75 dB, respectively. In addition, the measured peak range sidelobe level of the proposed method yielded lower values than the PCRF and PCCBB, and it also derived a suitable target location, i.e., a <0.07-mm target location error, while maintaining the axial resolution. In an in vivo abdominal experiment, the PCCBB-Dynamic method depicted brighter and clearer features in the hyperechoic region because highly correlated signals were produced by compensating for tissue attenuation. These results demonstrated that the proposed method can improve the SNR of chirp-coded excitation while preserving the axial resolution and the target location and reducing the computational complexity.</P>

      • SCISCIESCOPUS

        High PRF ultrafast sliding compound doppler imaging: fully qualitative and quantitative analysis of blood flow

        Kang, Jinbum,Jang, Won Seuk,Yoo, Yangmo Institute of Physics in association with the Ameri 2018 Physics in medicine & biology Vol.63 No.4

        <P>Ultrafast compound Doppler imaging based on plane-wave excitation (UCDI) can be used to evaluate cardiovascular diseases using high frame rates. In particular, it provides a fully quantifiable flow analysis over a large region of interest with high spatio-temporal resolution. However, the pulse-repetition frequency (PRF) in the UCDI method is limited for high-velocity flow imaging since it has a tradeoff between the number of plane-wave angles (<I>N</I>) and acquisition time. In this paper, we present high PRF ultrafast sliding compound Doppler imaging method (HUSDI) to improve quantitative flow analysis. With the HUSDI method, full scanline images (i.e. each tilted plane wave data) in a Doppler frame buffer are consecutively summed using a sliding window to create high-quality ensemble data so that there is no reduction in frame rate and flow sensitivity. In addition, by updating a new compounding set with a certain time difference (i.e. sliding window step size or <I>L</I>), the HUSDI method allows various Doppler PRFs with the same acquisition data to enable a fully qualitative, retrospective flow assessment. To evaluate the performance of the proposed HUSDI method, simulation, <I>in vitro</I> and <I>in vivo</I> studies were conducted under diverse flow circumstances. In the simulation and <I>in vitro</I> studies, the HUSDI method showed improved hemodynamic representations without reducing either temporal resolution or sensitivity compared to the UCDI method. For the quantitative analysis, the root mean squared velocity error (RMSVE) was measured using 9 angles (−12° to 12°) with <I>L</I> of 1–9, and the results were found to be comparable to those of the UCDI method (<I>L</I>  =  <I>N</I>  =  9), i.e.  ⩽0.24 cm s<SUP>−1</SUP>, for all <I>L</I> values. For the <I>in vivo</I> study, the flow data acquired from a full cardiac cycle of the femoral vessels of a healthy volunteer were analyzed using a PW spectrogram, and arterial and venous flows were successfully assessed with high Doppler PRF (e.g. 5 kHz at <I>L</I>  =  4). These results indicate that the proposed HUSDI method can improve flow visualization and quantification with a higher frame rate, PRF and flow sensitivity in cardiovascular imaging.</P>

      • An efficient pulse compression method of chirp-coded excitation in medical ultrasound imaging

        Changhan Yoon,Wooyoul Lee,Jin Chang,Tai-kyong Song,Yangmo Yoo IEEE 2013 and Frequency Control Vol.60 No.10

        <P>Coded excitation can improve the SNR in medical ultrasound imaging. In coded excitation, pulse compression is applied to compress the elongated coded signals into a short pulse, which typically requires high computational complexity, i.e., a compression filter with a few hundred coefficients. In this paper, we propose an efficient pulse compression method of chirp-coded excitation, in which the pulse compression is conducted with complex baseband data after downsampling, to lower the computational complexity. In the proposed method, although compression is conducted with the complex data, the L-fold downsampling is applied for reducing both data rates and the number of compression filter coefficients; thus, total computational complexity is reduced to the order of 1/L<SUP>2</SUP>. The proposed method was evaluated with simulation and phantom experiments. From the simulation and experiment results, the proposed pulse compression method produced similar axial resolution compared with the conventional pulse compression method with negligible errors, i.e., >36 dB in signal-to-error ratio (SER). These results indicate that the proposed method can maintain the performance of pulse compression of chirp-coded excitation while substantially reducing computational complexity.</P>

      • A single FPGA-based portable ultrasound imaging system for point-of-care applications

        Gi-Duck Kim,Changhan Yoon,Sang-Bum Kye,Youngbae Lee,Jeeun Kang,Yangmo Yoo,Tai-kyong Song IEEE 2012 and Frequency Control Vol.59 No.7

        <P>We present a cost-effective portable ultrasound system based on a single field-programmable gate array (FPGA) for point-of-care applications. In the portable ultrasound system developed, all the ultrasound signal and image processing modules, including an effective 32-channel receive beamformer with pseudo-dynamic focusing, are embedded in an FPGA chip. For overall system control, a mobile processor running Linux at 667 MHz is used. The scan-converted ultrasound image data from the FPGA are directly transferred to the system controller via external direct memory access without a video processing unit. The potable ultrasound system developed can provide real-time B-mode imaging with a maximum frame rate of 30, and it has a battery life of approximately 1.5 h. These results indicate that the single FPGA-based portable ultrasound system developed is able to meet the processing requirements in medical ultrasound imaging while providing improved flexibility for adapting to emerging POC applications.</P>

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