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        Can tumor recurrence be reduced with plasma-kinetic vaporization of the area around the tumor in nonmuscle invasive bladder cancer?

        Yüksel Yılmaz,Mehmet Cemal Kahya,Fatma Hüsniye Dilek,Osman Köse,Serkan Özcan,Ertan Can,Yiğit Akın,Batuhan Ergani,Ahmet Selçuk Dindar 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.4

        Purpose: To investigate the effect on recurrence of vaporization of the tumor surroundings and suspicious areas with a plasma-kinetic (PK) system after transurethral resection (TUR) of nonmuscle invasive bladder cancer. Materials and Methods: The study included 121 patients with a primary superficial bladder tumor who were randomized as those who underwent TUR with the PK system (Group 1, n=62) and those who underwent TUR with the monopolar system (Group 2, n=59). The vaporization procedure was performed by suppressing the cutting option of the PK system for a period, which would accumulate energy sufficient to make swelling-waves on the mucosa very close to the area of the loop to be vaporized. Results: A total of 121 patients who met the study criteria were included for evaluation. Recurrence was determined in 21 patients in Group 1 (33.87%) and in 29 patients in Group 2 (49.15%) (p=0.088). Recurrence was close to the old resection site in 6 of 21 patients in Group 1, and in 13 patients in Group 2 (p=0.028); the difference was statistically significant. No statistically significant difference was determined between the two groups with respect to age, gender, number of tumor foci, rate or range of additional treatments applied, cigarette smoking rate, repeat TUR rate and rate of tumor en- countered in repeat TUR, T-stage, and tumor grade. Conclusions: The effect of vaporization on recurrence by the PK system may seem similar to the effect of standard TUR, the recurrence- lowering effect surrounding nonmuscle invasive bladder cancers is better.

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        Experimental and factorial study on gas separation properties of PLA-based green composite membranes

        Yılmaz Sedef Yüksel,Özen Hülya Aykaç,Geyikçi Feza 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.12

        Polylactide acid (PLA) is a biocompatible sustainable material with notable characteristics due to its good mechanical properties and low environmental impact. The present study investigated the effects of PLA-based green membranes on gas separation and identified the best factor condition for the membrane. Prepared membranes were tested to determine oxygen (O2) and carbon dioxide (CO2) gas permeability properties. Oxygen gas permeability of the PLA/PEG/HA membrane obtained by drying for two days was increased from 100 kPa to 400 kPa; the permeability value of this membrane increased by 15%. On the other hand, the oxygen permeability value of the membrane prepared by dry for three days under the same pressure conditions and ambient temperature increased by 5%. This result indicates that the permeabilities of prepared membranes for O2 gas increase with increasing feed pressures. On the other hand, it was observed that the CO2 permeability decreased by 38.83% with the increase in pressure and drying time due to the plasticizing and swelling effect of carbon dioxide on the membrane. A factorial design was also constructed from experimental data and applied to determine the interactions of experimental parameters. All of the parameter interactions were of statistical significance for permeability. It is further argued that molecular weight has a significant positive effect on permeability, while dry time and pressure have just a slight negative effect. This study could contribute to further studies by reducing the number of tests necessary to understand the characteristics and gas separation performance of green materials.

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