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RISS 인기검색어
- 검색키워드
- 저자 : Xuyang Lv (검색결과 4 건)
- 무료
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Wenbing Shangguan,Xuyang Lv,Nan Tian 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of O6-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.
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Shangguan, Wenbing,Lv, Xuyang,Tian, Nan The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.
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Thermal Model for Power Converters Based on Thermal Impedance
Xu, Yang,Chen, Hao,Lv, Sen,Huang, Feifei,Hu, Zhentao The Korean Institute of Power Electronics 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.6
In this paper, the superposition principle of a heat sink temperature rise is verified based on the mathematical model of a plate-fin heat sink with two mounted heat sources. According to this, the distributed coupling thermal impedance matrix for a heat sink with multiple devices is present, and the equations for calculating the device transient junction temperatures are given. Then methods to extract the heat sink thermal impedance matrix and to measure the Epoxy Molding Compound (EMC) surface temperature of the power Metal Oxide Semiconductor Field Effect Transistor (MOSFET) instead of the junction temperature or device case temperature are proposed. The new thermal impedance model for the power converters in Switched Reluctance Motor (SRM) drivers is implemented in MATLAB/Simulink. The obtained simulation results are validated with experimental results. Compared with the Finite Element Method (FEM) thermal model and the traditional thermal impedance model, the proposed thermal model can provide a high simulation speed with a high accuracy. Finally, the temperature rise distributions of a power converter with two control strategies, the maximum junction temperature rise, the transient temperature rise characteristics, and the thermal coupling effect are discussed.
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Xu Yang,Yuan-Ping Lv 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6
Isolation and purification of antioxidants with strongest activities using a guided strategy with 2,2,-diphenyl-1-picrylhydrazyl (DPPH) were performed. Crude extracts were obtained from Tartary buckwheat hulls using 70% ethanol. After polar-solvent extraction and purification using silica gel, Sephadex LH-20, and MCI gel CHP 20P column chromatography, the active component was subjected to structural identification. HPLC analysis indicated a high-purity yield for the purification process. Results of ultraviolet-visible spectrometry and HPLC with electrospray ionization mass spectrometry indicated that the main component was quercetin, with micro-quercetin-3-rhamnoside and kaempferol. Agarose gel electrophoresis revealed the potential of the purified active component as an in vitro protectant against DNA damage. Dose-dependent damage protection was observed for all tested concentrations. Quantitative analysis indicated the active component combines with radicals derived from H2O2 + UV treatment for termination of the radical chain reaction.
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