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- 저자 : Xiaohang Guo (검색결과 3 건)
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Yani Guo,Ming Li,Xuan Wen,Xiaohang Guo,Tiantian Zhang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.7
Superhydrophilic and underwater superoleophobic membrane materials have been widely studied owing to theirexcellent separation efficiency. However, the oil-fouling problem is a major drawback limiting their practical oil/waterseparation applications. Herein, a silica-enhanced functionalized poly(styrene-alt-maleic anhydride)/fluorocarbon surfactantnanofibrous composite membrane (f-PSMA/FS/SiO2) with underwater superoleophobicity was fabricated by theelectrospinning method. The uniformly dispersed silica nanoparticles not only increased the roughness of the as-preparedcomposite membrane but also substantially improved the underwater superoleophobicity. Therefore, the as-preparedcomposite membrane showed excellent underwater anti-oil-fouling performance, thus preventing the decrease in theseparation efficiency and flux caused by membrane fouling during oil/water separation. Throughout 60 separation cyclessolely driven by gravity, the separation efficiencies were above 99.27 %, and the flux remained higher than 3743 L m-2 h-1. More importantly, the as-prepared composite membrane maintained exceptional underwater superoleophobicity in a harshenvironment (30 wt% NaCl for 12 h, pH 1 (HCl) for 12 h, oven temperature at 90 °C for 2 h). Thus, because of its robustthermal stability and chemical durability, the antifouling f-PSMA/FS/SiO2 composite membrane has tremendous potential forfuture practical applications in the treatment of oily wastewater.
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Influence of flow-induced oscillating disturbance on the surface heat transfer of impingement flow
Xiaohang Qu,Xiaoni Qi,Qianjian Guo,Yongqi Liu 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.11
Flow-induced oscillation is an effective way to enhance heat transfer, which requires no extra energy consumption and can prevent fouling and soot formation. To test the flow-induced oscillation effect on the heat transfer of impingement flow, an 18 mm wide and 30 m thick membrane tape was mounted at the exit of the ejection pipe. As the ejection Reynolds number increased from 5280 to 9827, the oscillating frequency also increased. In addition, three different oscillating regimes were observed, these being quasi-still, 2D-oscillating and 3D-oscillating, with the transition Re depending on the tape length. The heating plate was 3D-printed and electrical heating wires were embedded within it so as to predetermine the local heat flux by numerical analysis, and be able to calculate the heat transfer coefficient (HTC). The results demonstrate that heat transfer enhancement is more prominent in the vertical direction to the tape than in the parallel direction. Moreover, the distinctive heat transfer enhancement effect near the plate center becomes weaker as it goes toward the outside of the plate, and even turns negative with an increasing r/D. Using a longer piece of tape or having smaller intervals between the tape tip and plate was also shown to improve the heat transfer effect. The spontaneous oscillating disturbance method shows great promise for heat transfer regulation in impingement flow.
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Gao Ran,Guo Wenjun,Fan Tianfei,Pang Junling,Hou Yangfeng,Feng Xiaohang,Li Bolun,Ge Weipeng,Fan Tianhui,Zhang Tiantian,Lu Jiakai,Jing He,Jin Mu,Yan Chen,Wang Jing 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Abdominal aortic aneurysm (AAA) is a permanent expansion of the abdominal aorta that has a high mortality but limited treatment options. Phosphodiesterase (PDE) 4 family members are cAMP-specific hydrolyzing enzymes and have four isoforms (PDE4A-PDE4D). Several pan-PDE4 inhibitors are used clinically. However, the regulation and function of PDE4 in AAA remain largely unknown. Herein, we showed that PDE4D expression is upregulated in human and angiotensin II-induced mouse AAA tissues using RT-PCR, western blotting, and immunohistochemical staining. Furthermore, smooth muscle cell (SMC)-specific Pde4d knockout mice showed significantly reduced vascular destabilization and AAA development in an experimental AAA model. The PDE4 inhibitor rolipram also suppressed vascular pathogenesis and AAA formation in mice. In addition, PDE4D deficiency inhibited caspase 3 cleavage and SMC apoptosis in vivo and in vitro, as shown by bulk RNA-seq, western blotting, flow cytometry and TUNEL staining. Mechanistic studies revealed that PDE4D promotes apoptosis by suppressing the activation of cAMP-activated protein kinase A (PKA) instead of the exchange protein directly activated by cAMP (Epac). Additionally, the phosphorylation of BCL2-antagonist of cell death (Bad) was reversed by PDE4D siRNA in vitro, which indicates that PDE4D regulates SMC apoptosis via the cAMP-PKA-pBad axis. Overall, these findings indicate that PDE4D upregulation in SMCs plays a causative role in AAA development and suggest that pharmacological inhibition of PDE4 may represent a potential therapeutic strategy.
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