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Postmenopausal Hormone Therapy is Associated with in Situ Breast Cancer Risk
Ni, Xiao-Jian,Xia, Tian-Song,Zhao, Ying-Chun,Ma, Jing-Jing,Zhao, Jie,Liu, Xiao-An,Ding, Qiang,Zha, Xiao-Ming,Wang, Shui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Background: The relationship between postmenopausal hormone therapy (HT) and invasive breast cancer has been extensively investigated, but that with breast carcinoma in situ (BCIS) has received relatively little attention. The aim of our present study was to review and summarize the evidence provided by longitudinal studies on the association between postmenopausal HT use and BCIS risk. Methods: A comprehensive literature search for articles published up to May 2012 was performed. Prior to performing a meta-analysis, the studies were evaluated for publication bias and heterogeneity. Relative risk (RR) or odds ratio (OR) values were calculated using 14 reports (8 case-control studies and 6 cohort studies), published between 1986 and 2012. Results: There was evidence of an association between ever postmenopausal estrogen use and BCIS based on a random-effects model (RR = 1.25, 95% confidence interval (CI) = 1.01, 1.55). However, we found no strong evidence of an association between ever postmenopausal estrogen combined with progesterone use and BCIS using a randomeffects model (RR = 1.55, 95% CI = 0.95, 2.51). Furthermore, our analysis showed a strong association between "> 5 years duration" of estrogen or estrogen combined with progesterone use and BCIS. Furthermore, current use of any HT is associated with increased risk of BCIS in cohort studies. Additional well-designed large studies are now required to validate this association in different populations.
Development and Evaluation of a Patient-Reported Outcome (PRO) Scale for Breast Cancer
Zhang, Jun,Yao, Yu-Feng,Zha, Xiao-Ming,Pan, Li-Qun,Bian, Wei-He,Tang, Jin Hai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: This study was guided by principles of the theoretical system of evidence-based medicine. In particular, when searching for evidence of breast cancer, a measuring scale is an instrument for evaluating curative effects in accordance with the laws and characteristics of medicine and exploring the establishment of a system for medically assessing curative effects. At present, there exist few tools for evaluating curative effects. Patient-reported outcomes (PROs) refer to outcomes directly reported by patients (without input or explanations from doctors or other intermediaries) with respect to all aspects of their health. Data obtained from PROs provide evidence of treatment effects. Materials and Methods: In accordance with the tenets of theoretical medicine and ancient medical theory regarding breast cancer, principles for developing a PRO scale were established, and a theoretical model was developed and a literature review was performed, items from this pool were combined and split, and an initial scale was constructed. After a pilot survey and additional modifications, a pre-questionnaire scale was formed and used in a field investigation. After the application of statistical methods, the item pool was used to create a formal scale. The reliability, validity and feasibility of this formal scale were then assessed. Results: In a clinical investigation, 479 responses were recovered, with an acceptance rate of 95%. a combination of various methods was employed, and the items that were selected by all methods or more than half of the methods were employed in the questionnaire. In these cases, the screening methods were combined with certain features of the item, A total of four domains and 38 items were reserved. The reliability analysis indicated that the PRO scale was relatively reliable. Conclusions: Scientific assessment proved that the proposed scale exhibited good reliability and validity. This scale was readily accepted and could be used to assess the curative effects of medical therapy. However, given the limited scope of this investigation, the capacity for adapting this scale to incorporate other theories could not be determined.
Jian-jun Sun,Wei Hu,Hui Zhou,Yi-ming Jiang,Xiao-ming Zha 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.4
Multiple parallel inverters have multiple resonant frequencies that are influenced by many factors. This often results in stability and power quality problems. This paper develops a multiple input multiple output model of grid-connected inverter systems using a closed-loop transfer function. The influence factors of the resonant characteristics are analyzed with the developed model. The analysis results show that the resonant frequency is closely related to the number, type and composition ratio of the parallel inverters. To suppress resonance, a scheme based on virtual impedance is presented, where the virtual impedance is emulated in the vicinity of the resonance frequency. The proposed scheme needs one inverter with virtual impedance control, which reduces the design complexity of the other inverter controllers. Simulation and experimental tests are carried out on two single phase converter-based setups. The results validate the correctness of the model, the analytical results and the resonant suppressing scheme.
Sun, Jian-jun,Hu, Wei,Zhou, Hui,Jiang, Yi-ming,Zha, Xiao-ming The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.4
Multiple parallel inverters have multiple resonant frequencies that are influenced by many factors. This often results in stability and power quality problems. This paper develops a multiple input multiple output model of grid-connected inverter systems using a closed-loop transfer function. The influence factors of the resonant characteristics are analyzed with the developed model. The analysis results show that the resonant frequency is closely related to the number, type and composition ratio of the parallel inverters. To suppress resonance, a scheme based on virtual impedance is presented, where the virtual impedance is emulated in the vicinity of the resonance frequency. The proposed scheme needs one inverter with virtual impedance control, which reduces the design complexity of the other inverter controllers. Simulation and experimental tests are carried out on two single phase converter-based setups. The results validate the correctness of the model, the analytical results and the resonant suppressing scheme.