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Xiao‑xia Ma,Yi‑ning Wang,Xiao‑an Cao,Xue‑rui Li,Yong‑sheng Liu,Jian‑hua Zhou,Xue‑peng Cai 한국유전학회 2018 Genes & Genomics Vol.40 No.9
The nucleocapsid (N) protein of peste des petits ruminants virus (PPRV) with a conserved amino acid usage pattern plays an important role in viral replication. The primary objective of this study was to estimate roles of synonymous codon usages of PPRV N gene and tRNA abundances of host in the formation of secondary structure of N protein. The potential effects of synonymous codon usages of N gene and tRNA abundances of host on shaping different folding units (α-helix, β-strand and the coil) in N protein were estimated, based on the information about the modeling secondary structure of PPRV N protein. The synonymous codon usage bias was found in different folding units in PPRV N protein. To better understand the role of translation speed caused by variant tRNA abundances in shaping the specific folding unit in N protein, we modeled the changing trends of tRNA abundance at the transition boundaries from one folding unit to another folding unit (β-strand → coil, coil → β-strand, α-helix → coil, coil → α-helix). The obvious fluctuations of tRNA abundance were identified at the two transition boundaries (β-strand → coil and coil → β-strand) in PPRV N protein. Our findings suggested that viral synonymous codon usage bias and cellular tRNA abundance variation might have potential effects on the formation of secondary structure of PPRV N protein.
Evolving Recommender System for Mobile Apps
Xiao Xia,Xiaodong Wang,Xingming Zhou 한국산학기술학회 2013 SmartCR Vol.3 No.3
The explosive growth of mobile apps gives rise to the significant challenge of app discovery. For this reason, Google Play utilizes a collaborative filtering approach for recommending apps to users by analyzing user behavior. Those recommendations help users discover apps by referring to the experiences of other users. However, their choices may also be limited because most users only know about a limited number of apps. To eliminate such constraints, we propose a novel recommendation method utilizing global information about apps. We generate recommendations by both analyzing the metadata and measuring the similarity between apps, leveraging the Latent Semantic Index method. To understand both methods, we further measure the diversity within them. Through those measurements, we not only gain better understanding of both recommendation methods but also discover new knowledge about user preferences. Such measurements also identify the necessity and potential to evolve the existing system. We therefore propose a diversity measurement?based evolution framework for the development of mobile app recommender systems. To implement the framework, we further model the system evolution as a multi-criteria optimization problem and design a rank aggregation scheme to solve it. Preliminary evaluations verified the promising effectiveness of our framework and method based on a data set of 103,348 apps.
Xiao-Xu Xia 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.10
In this paper, the problem of delay-dependent absolute stability condition for a new class of Takagi-Sugeno (T-S) fuzzy Lurie control systems with time-varying delay is investigated. New Lyapunov functions are defined by utilizing the Lyapunov-Krasovskii functional (LKF). Meanwhile, free-weighting matrix method and some techniques are used to obtain a new absolute stability condition, which is different from previous research. Finally, a numerical example will be provided to demonstrate feasibility and less conservativeness of the proposed result.
The Delay-dependent Condition for Uncertain T-S Fuzzy Lurie Control Systems with Time-delay
Xiao-Xu Xia 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.5
The problem of delay-dependent condition for a new class of Takagi-Sugeno (T-S) fuzzy Lurie control systems with time-delay and time-variant uncertainties is investigated in this paper, which is different from existing ones. We use T-S fuzzy models to describe Lurie system in the form of a weighted sum of some simple linear subsystems, and a new delay-dependent absolute stability criterion for such systems is derived by utilizing Lyapunov-Krasovskii functional (LKF), linear matrix inequality (LMI) approach and novel techniques. Finally, a numerical example and its simulation results have shown that the proposed result is feasible and effective.
Xiao, Yang,Liu, Jun,Huang, Xin-En,Ca, Li-Hua,Ma, Yi-Min,Wei, Wei,Zhang, Rong-Xia,Huang, Xiao-Hong,Chang, Juan,Wu, Yi-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Objective: To observe treatment effects and safety of fluvoxamine combined with oxycodone prolonged-release tablets in treating patients with moderate to severe cancer pain. Methods: Patients confirmed pathologically with cancer and complicated with moderate to severe pain, were divided into control and experimental groups. Oxycodone prolonged-release tablets, with or without fluvoxamine, were administrated to all study patients until pain relief. Degree of pain relief, dose of oxycodone prolonged-release tablets, side effects and quality of life were compared before and after treatment. Results: In total, 120 patients were recruited. No statistically significant difference was detected regarding age, gender, types of cancer, KPS between two groups of patients (P>0.05). Baseline pain score of patients with moderate pain in treatment and control group was $4.9{\pm}0.8$ and $5.1{\pm}0.8$, respectively; and decreased to $1.8{\pm}1.1$ and $1.2{\pm}1.1$ after treatment, respectively. Pain intensity was significantly reduced in the treatment group (P=0.028). Average daily consumption of oxycodone prolonged-release tablets was ($54.0{\pm}19.6$) mg and ($44.7{\pm}18.7$) mg respectively, which is lower in treatment grpup than in control group, but the difference was not statistically significant (P=0.065). Baseline pain score of patients with severe pain in treatment and control groups were $8.3{\pm}1.1$ and $8.3{\pm}1.1$, respectively; and pain intensity after treatment decreased to $2.9{\pm}1.0$ and $2.3{\pm}1.0$. Pain intensity was significantly reduced in the treatment group, with statistical significance (P=0.026). Average daily consumption of oxycodone prolonged-release tablets was ($132.0{\pm}42.2$) mg and ($110.7{\pm}33.9$) mg, respectively, which is lower in treatment group than in control group, and the difference was statistically significant (P=0.035). In terms of quality of life, patients in treatment group had better performance status, daily activity, mood, and sleep than that in control group (P < 0.05). Patients in two groups had similar side effects, eg., constipation, nausea/vomiting, lethargy, dizziness, itchy skin, dysuria, and ataxia. Lower incidence of nausea/vomiting, lethargy, was obtained from patients in treatment than in control group, while significant low constipation was observed in treatment than in control group (35.0% vs 49.2%, P=0.026). Conclusion: Fluvoxamine combined with oxycodone prolonged-release tablets could be more effective in treating patients with cancer pain, and could reduce the dosage of oxycodone prolonged-release tablets and thus be associated with lower side effects, and improved quality of life.
Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases
Xiao, Xiong,Liu, Hui-Xia,Shen, Kuo,Cao, Wei,Li, Xiao-Qiang The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of $Ca^{2+}$ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebro-vascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.