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RISS 인기검색어
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- 저자 : Xiangjin Qiao (검색결과 2 건)
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Xu, Chunlan,Sun, Rui,Qiao, Xiangjin,Xu, Cuicui,Shang, Xiaoya,Niu, Weining,Chao, Yu The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control), high altitude hypoxia (HH), and high altitude hypoxia + vitamin E (250 mg/kg $BW^*d$) (HV) groups. After the third day, the HH and HV groups were placed in a hypobaric chamber at a stimulated elevation of 7000 m for 5 days. The rats in the HV group were given vitamin E by gavage daily for 8 days. The other rats were given equal volume saline. The results showed that high altitude hypoxia caused the enlargement of heart, liver, lung and kidney, and intestinal villi damage. Supplementation with vitamin E significantly alleviated hypoxia-caused damage to the main organs including intestine, increased the serum superoxide dismutase (SOD) (p< 0.05), diamino oxidase (DAO) (p< 0.01) levels, and decreased the serum levels of interleukin-2 (IL-2) (p< 0.01), interleukin-4 (IL-4) (p<0.001), interferon-gamma ($IFN-{\gamma}$) (p<0.01) and malondialdehyde (MDA) (p<0.001), and decreased the serum erythropoietin (EPO) activity (p<0.05). Administration of vitamin E significantly increased the S-IgA (p<0.001) in ileum and significantly improved the expression levels of occludin and $I{\kappa}B{\alpha}$, and decreased the expression levels of hypoxia-inducible factor 1 alpha and 2 alpha ($HIF-1{\alpha}$ and $HIF-2{\alpha}$), Toll-like receptors (TLR4), P-$I{\kappa}B{\alpha}$ and nuclear factor-${\kappa}B$ p65(NF-${\kappa}B$ P65) in ileum compared to the HH group. This study suggested that vitamin E protectis from intestinal injury caused by high altitude hypoxia environment. These effects may be related to the HIF and TLR4/NF-${\kappa}B$ signaling pathway.
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Chunlan Xu,Rui Sun,Xiangjin Qiao,Xiaoya Shang,Weining Niu,Yu Chao 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induceddamage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control), highaltitude hypoxia (HH), and high altitude hypoxia+ vitamin E (250 mg/kg BW*d) (HV) groups. Afterthe third day, the HH and HV groups were placed in a hypobaric chamber at a stimulated elevationof 7000 m for 5 days. The rats in the HV group were given vitamin E by gavage daily for 8 days. The other rats were given equal volume saline. The results showed that high altitude hypoxia causedthe enlargement of heart, liver, lung and kidney, and intestinal villi damage. Supplementation withvitamin E significantly alleviated hypoxia-caused damage to the main organs including intestine,increased the serum superoxide dismutase (SOD) (p< 0.05), diamino oxidase (DAO) (p< 0.01) levels,and decreased the serum levels of interleukin-2 (IL-2) (p< 0.01), interleukin-4 (IL-4) (p<0.001),interferon-gamma (IFN-γ) (p<0.01) and malondialdehyde (MDA) (p<0.001), and decreased the serumerythropoietin (EPO) activity (p<0.05). Administration of vitamin E significantly increased the S-IgA(p<0.001) in ileum and significantly improved the expression levels of occludin and IκBα, anddecreased the expression levels of hypoxia-inducible factor 1 alpha and 2 alpha (HIF-1α and HIF-2α),Toll-like receptors (TLR4), P-IκBα and nuclear factor-κB p65(NF-κB P65) in ileum compared to theHH group. This study suggested that vitamin E protectis from intestinal injury caused by high altitudehypoxia environment. These effects may be related to the HIF and TLR4/NF-κB signaling pathway.
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