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Spontaneous Ovarian Cyst Occuring in CD-1 Mice during 2-year Carcinogenic Test
Woo-Chan Son 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
Spontaneous ovarian pathology of the mouse is well documented elsewhere in the literature. However, naturally occurring ovarian cystic lesions and its detailed incidence have not been made well. This report is intended to establish a general incidence profile of ovarian cysts in aged CD-1 mice. Data from 10 mouse 2-year carcinogenicity studies conducted between 1990 and 2003 at Huntingdon Life Sciences, UK, were collected and evaluated. The analysis was confined to ovaries in control groups. Cystadenoma (0.4%) and cysts (59.9%) were the most common tumour and non-neoplastic findings, respectively. The most frequently occurring cyst was follicular cyst (59.4%), followed by corpus luteal cyst (34.8%) and parovarian cyst (3.8%).
Idiopathic canine polyarteritis in control beagle dogs from toxicity studies
Woo-Chan Son 대한수의학회 2004 Journal of Veterinary Science Vol.5 No.2
It is sometimes difficult to assess the relevance of polyarteritis with treatment-related lesions in dog toxicity studies, as number of dogs used in a toxicity study is small and the lesions are similar to those seen in spontaneous diseases. This report is intended to establish a general profile of idiopathic canine polyarteritis in beagle dogs. Data from a total of 40 dog studies including 4-, 13- or 52-weeks studies conducted between 1990 and 2003 at Huntingdon Life Sciences, UK, were collected and analysed. There was no death by this disease and also no prominent clinical signs related to this disease. Histologically, males tended to develop polyarteritis more frequently than in females and epididymis is the most probable tissues, followed by thymus and heart. Dogs in two studies showed higher incidences of these lesions, whereas animals in the other studies did not exhibited, suggesting that genetic predilection plays an important role in this disease.
Filaroides hirthi Lung Worm Induced Pulmonary Lesions in Beagle Dogs
Woo-Chan Son 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.1
This report is intended to establish a general incidence profile of filaroides hirthi infection in beagle dogs. Data from 17 dog studies from the controls of 4- or 13 weeks studies, 118 dogs in total, conducted between 1990 and 2004 at Huntingdon Life Sciences, UK, were collected and evaluated. There were no deaths or prominent clinical signs either. From the histological diagnosis, 4 (3.4%) dogs showed filaroides hirthi, which consisted of 2 (3.4%) males and 2 (3.4%) females. Lungs were the most commonly affected organs, which were principally associated with pleural thickening and fibrosis, subpleural alveolar septal fibrosis with epithelial hyperplasia, and subpleural lymphoid foci.