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        Applying Ecological Principles of Design for Restoring Brownfields: A Case Study in River Rouge, MI

        Andreea Bodea,김준현,Wonmin Sohn,Noah Durst 인간식물환경학회 2023 인간식물환경학회지 Vol.26 No.5

        Background and objective: Failing industrial cities have left behind a legacy of social, economic, and environmental decline. The aftermath includes cities that have experienced departing residents, decaying infrastructure, and urban blight. Althoughthere are many contributing factors to degradation, for cities such as Detroit, MI, much of its infrastructure has become vacant,and due to previous heavy industrial use, some of the lots have turned into brownfields. This research aims to create adesign guideline for revitalizing industrial vacant lands or brownfields through the application of ecological design principles. Methods: By adopting a case study approach, this research focuses on safely reconstructing the economic, social, andenvironmental health of communities by creating an ecological design matrix based on the landscape ecology principles ofdesign; and applying those elements to the 80" Hot Mill company, located in River Rouge, MI, United States. Additionally,a landscape performance assessment was conducted to evaluate the benefits of the proposed planning and outcomesregarding environmental, social, and economic aspects. Results: Following the creation of a master plan, the post-design metrics show positive environmental outputs such as thereduction of carbon sequestration, air pollution elements, waste from the site, and an increase in the retention ofstormwater. The social impacts measured showed favorable outcomes which included visual quality, safety features, theaddition of recreational and gathering spaces, as well as bike lanes and pedestrian walking paths. Economically,improvements have been seen in stormwater maintenance costs and energy savings. Conclusion: The findings from this research aim to help future designers and planners in implementing ecological designprinciples in order to optimize the restoration processes of brownfields and vacant lands.

      • Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus <i>Aspergillus</i> sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

        Kim, Dong-Cheol,Cho, Kwang-Ho,Ko, Wonmin,Yoon, Chi-Su,Sohn, Jae Hak,Yim, Joung Han,Kim, Youn-Chul,Oh, Hyuncheol MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.4

        <P>In the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus <I>Aspergillus</I> sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS) generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways.</P>

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        Developing A Revitalization Planning and Design Guideline for Enhancing Land Use Performance of a Shrinking City

        Shu Yang,Jun-Hyun Kim,Wonmin Sohn,Zeenat Kotval-K 인간식물환경학회 2020 인간식물환경학회지 Vol.23 No.4

        Background and objective: Land vacancy is a persistent issue inmost urban areas in the United States, yet few case studies have examined how vacant lots are used and the functions they serve in local communities. The purposes of this study were to provide a new revitalization planning and design proposal for the Durant-Tuuri-Mott (DTM) target area in the shrinking city of Flint, MI, USA, and to assess the final planning and design guideline through an analysis of vacant land redevelopment alternatives. Methods: For developing a revitalization planning and design guideline, this study developed several design modules with three main design themes. Then, landscape performance of the final design proposals was analyzed by three development scenarios, based on implementation level: 100%, 75%, and 50%. These development scenarios were based on the local context and different implementation budgets needed to adopt the proposed design modules. To generate a comprehensive development plan by optimizing design module allocation in the study area, this research employed a system-oriented approach, analyzing the existing cultural, natural, and built environments. A community participant process was adopted to collect stakeholders’ opinions on future development. Results: By utilizing landscape performance metrics to quantify the environmental, social, and economic benefits, this study developed optimized development scenarios and a master plan for the reuse and redevelopment of existing vacant lots across DTM neighborhoods and analyzed the benefits of each. Conclusion: This research offers a flexible design method for balancing objectives in vacant land redevelopment that can be applied in other shrinking cities.

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