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The Effect of Caffeic Acid on the Antinociception and Mechanisms in Mouse
Park, Soo-Hyun,Sim, Yun-Beom,Kim, Seon-Mi,Lee, Jin-Koo,Jung, Jun-Sub,Suh, Hong-Won The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
Antinociceptive profiles of caffeic acid were examined in ICR mice. Caffeic acid administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Moreover, the cumulative response time of nociceptive behaviors induced by an intraplantar formalin injection was reduced by caffeic acid treatment during the 2nd phases. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7{\mu}g$) or glutamate ($20{\mu}g$) was diminished by caffeic acid. Intraperitoneal (i.p.) pretreatment with yohimbine (${\alpha}_2$-adrenergic receptor antagonist) or naloxone (opioid receptor antagonist) attenuated antinociceptive effect induced by caffeic acid in the writhing test. However, methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by caffeic acid in the writhing test. Our results suggest that caffeic acid shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of caffeic acid may be mediated by ${\alpha}_2$-adrenergic and opioidergic receptors, but not serotonergic receptor.
Park, Soo-Hyun,Sim, Yun-Beom,Lim, Soon-Sung,Kim, Jin-Kyu,Lee, Jin-Koo,Kim, Seon-Mi,Suh, Hong-Won The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.1
In the present study, the antinociceptive profiles of Aralia cordata Thunb. extract were examined in ICR mice. A. cordata extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. A. cordata extract attenuated the writhing numbers in the acetic acid-induced writhing test and reduced the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7\;{\mu}g$). Intraperitoneal (i.p.) pretreatment with yohimbine (${\alpha}_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by A. cordata extract in the writhing test, whereas naloxone (opioid receptor antagonist) and methysergide (5HT2 serotonergic receptor antagonist) did not affect antinociception. Results suggest that A. cordata extract has an antinociceptive property in various pain models and may be mediated by ${\alpha}_2$-adrenergic receptor, but not by opioidergic and 5HT2 serotonergic receptors.
Antinociceptive Profiles and Mechanisms of Orally Administered Curcumin in Various Pain Models
Park, Soo-Hyun,Sim, Yun-Beom,Kim, Seon-Mi,Kang, Yu-Jung,Lee, Jin-Koo,Suh, Hong-Won The Korean Society for Applied Biological Chemisty 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.1
Antinociceptive profiles of curcumin in ICR mice were examined. Curcumin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of curcumin was maintained at least for 60 min. Moreover, cumulative response time of nociceptive behaviors induced with intraplantar formalin injection was reduced by curcumin treatment during second phase. Cumulative nociceptive response time for intrathecal injection of substance P (0.7 ${\mu}g$) or glutamate (20 ${\mu}g$) was diminished by curcumin. Intraperitoneal pretreatment with naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist)-attenuated antinociceptive effect induced by curcumin in the writhing test, whereas yohimbine (${\alpha}_2$-adrenergic receptor antagonist) did not affect antinociception induced by curcumin, suggesting that curcumin shows antinociceptive property in various pain models, and this antinociceptive effect of curcumin may be mediated by opioidergic and serotonergic receptors, but not ${\alpha}_2$-adrenergic receptor.
Park, K.,Yoon, D.H.,Lee, S.,Kwon, T.h.,Bae, G.,Hyun, S.,Kwon, Y.,Won, J.,Suh, J.,Kim, J.,Lee, S.,Bae, J. Pergamon Press ; Elsevier Science Ltd 2014 International journal of hydrogen energy Vol.39 No.24
A 6 kW class interconnector-type anode-supported tubular solid oxide fuel cell (ICT SOFC) stack is fabricated and operated in this study. An optimized current-collection method, which the method for current collection at the cathode using the winding method and is the method for the connection between cells using interconnect, is suggested to enhance the performance of the fabricated cell. That method can increase the current collection area because of usage of winding method for cell and make the connection between cells easy. The performance of a single cell with an effective electrode area of 205 cm<SUP>2</SUP> exhibits 51 W at 750 <SUP>o</SUP>C and 0.7 V. To assemble a 1 kW class stack, the prepared ICT SOFC cells are connected in series to 20 cells connected in parallel (20 cells in series x two in parallel, 20S2P). Four modules are assembled for a 6 kWe class stack. For one module, the prepared ICT SOFC cells are connected in series to 48 cells, in which one unit bundle consists of two cells connected in parallel. The performance of the stack in 3% humidified H<SUB>2</SUB> and air at 750 <SUP>o</SUP>C exhibits the maximum electrical power of 7425 W.
Park, Joong-Min,Suh, Suk-Won,Kwak, Jung-Myun,Kim, Jin,Kim, Seon-Hahn Lippincott Williams Wilkins 2011 Surgical laparoscopy, endoscopy & percutaneous tec Vol.21 No.5
<P>Laparoscopy-assisted colectomy is accepted as a standard procedure for colorectal resection. There have been many attempts to minimize the invasiveness of the procedure by reducing the number of operating ports and changing the specimen retrieval windows. Indeed, the invasiveness of laparoscopy-assisted colectomy has been minimized with these attempts; however, the technical challenges have increased. The technical challenges are related to lack of retraction and triangulation, which is necessary to expose the appropriate surgical field for safe surgery. A new technique based on retraction and triangulation with suspension suture traction for laparoscopy-assisted colorectal surgery is presented.</P>
Park, Sung-Sun,Oh, Sung-Hoon,Choi, Won-Dai,Ra, Kyung-Soo,Suh, Hyung-Joo The Korean Society of Food Science and Nutrition 2007 Preventive Nutrition and Food Science Vol.12 No.4
A physicochemical assessment of Doenjang (traditional fermented soyfood) prepared with Korean black soybeans (Glycine max) was carried out. The T-N rate increased slowly during storage up to 120 days and the A-N rate increased up to 80 days of ripening and then decreased slightly. The caseinolytic activity increased slowly during storage up to 80 days and then decreased after 80 days. In addition, the fibrinolytic and ${\beta}-glucosidase$ activities increased up to 80 and 30 days and then decreased. Genistin and daidzin concentrations gradually decreased with increased fermentation time. However, genistein and daidzein slowly increased with fermentation time. Genistein and daidzein reached maximum concentrations (316.8 and $305.2{\mu}g/g$, respectively) and plateaued thereafter. The anthocyanins increased greatly during fermentation up to 50 days and then remained constant between 50 and 90 days. Polyphenol contents showed a slight increase up to 80 days and then slowly decreased. The DPPH and ABTS radical scavenging activities increased linearly during storage up to 50 days, reached about 28.9% and 2.17 mg/g, respectively, and then slowly decreased. At 20 days of fermentation, macrophage-stimulating activity of the extract showed a maximum activity.
Park, Shin Jung,Hyun, Sun-Hee,Suh, Hyo Won,Lee, Seok-Young,Min, Tae-Sun,Auh, Joong-Hyuck,Lee, Hong-Jin,Kim, Jung-Hyun,Cho, Soo-Muk,Choi, Hyung-Kyoon 한국응용생명화학회 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.5
Random amplification of polymorphic DNA (RAPD) and NMR techniques were used to differentiate and identify species of black raspberry (BR) of different geographic origins. BR leaf samples from five geographic origins were identified as Rubus japonicus and R. coreanus by RAPD. $^1H$-NMR analysis was also performed for BR fruit extracts from different geographic origins. Major compounds assigned in $^1H$-NMR spectra of BR fruits were amino acids, organic acids, sugars, phenolic acids, and purine derivatives. In addition, relative levels of total phenolic compounds, flavanols, flavonoids, and anthocyanins in the BR fruits were further analyzed. Hierarchical cluster analyses (HCA) based on the genetic (RAPD of leaf samples) and metabolic ($^1H$-NMR, total phenolic compounds, flavanols, flavonoids and anthocyanins of fruit samples) datasets were independently performed. The HCA dendrogram pattern derived from RAPD genetic fingerprinting of BR leaf samples matched that from the $^1H$-NMR data of BR fruit samples. This research demonstrates that metabolic profiling of BR fruit based on $^1H$-NMR is a promising method for differentiating BR fruits of various species and geographic origins.
Changes of Soil Microbe communities in Plastic Film House by Green Manure Crops Cultivation
Won, J.G.,Jang, K.S.,Hwang, J.E.,Kwon, O.H.,Jeon, S.G.,Park, S.G.,Park, K.C.,Suh, Y.J. Korean Association of Organic Agriculture 2011 韓國有機農業學會誌 Vol.19 No.S
To improve the soil condition for no-tillage organic pepper cultivation, four different green manure crops were cultivated. Fertilizer supply was depended on the biomass of the cultivated green manure crops, nitrogen supplies were 314kg in Vicia villosa and 341kg $ha^{-1}$ in Vicia angustifolia. In the microbial community analyzed by phospholipid fatty acid (PLFA) method, soil microbe populations were different among the green manure crops and fungi group was increased at Vicia angustifloia and Vicia villosa. The biological ratio indexes of fatty acids in the soils, the ratio of Gram-negative to Gram-positive bacterial PLFA and Ratio of aerobes to anaerobes were high at Vicia hirsute and Vicia tetrasperma suggesting the enrich of the aerobic conditions. The ratio of saturated to unsaturated fatty acids increased at Vicia angustifloia and Vicia villosa suggesting anaerobic conditions. Abundant biomass and uncomposted organic matter, the ratio of fungi to bacteria was increased at Vicia angustifloia and Vicia villosa.