http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, Jisoo,Kim, Eun-Kyung,Kim, Mi-Ae,Kim, Tae-Hyung,Chang, Jung Hyun,Ryu, Yon Ju,Lee, Sei Won,Oh, Yeon-Mok,Yong, Suk Joong,Choi, Won-Il,Yoo, Kwang Ha,Lee, Ji-Hyun The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4
Background: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results: Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion: Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation.
The effect of synovium graft on conjunctiva in rabbit model of dry eye
Park, Keungjin,Nam, Kyungmin,Jang, Min,Lee, Won-Jae,Jeong, Seong Mok,Bae, Seulgi,Kwon, Young-Sam,Ku, Sae-Kwang,Yun, Sungho The Korean Society of Animal Reproduction and Biot 2021 한국동물생명공학회지 Vol.36 No.1
This study was performed to identify the effect of synovium graft on conjunctiva in rabbits after dry eye induction. Six New Zealand White rabbits were used as dry eye models. Both eyes were divided to two groups as control and synovium graft group. The synovium graft was performed in fourth week after dry eye modeling. Quantitative change of tears through Schirmer tear test (STT), qualitative change of tear film through tear film break up time (TFBUT), and damage of cornea through fluorescein staining were observed for 10 weeks at intervals of two weeks. Histological examination was performed to evaluate cornea and conjunctiva at tenth week. In both groups, STT and TFBUT were significantly decreased in 4 weeks after modeling compared to 0 weeks (p < 0.05) . After synovium graft, there were increases in STT value at 4 weeks and TFBUT at 4 and 6 weeks in graft group (p < 0.05). Corneal fluorescein staining showed no significant difference between the two groups. In histopathological examination, grafted synovium was detected as round to ovoid ingression folds, well attached to grafted regions with 0.11 ± 0.04 mm<sup>2</sup> (range, 0.05-0.16 mm<sup>2</sup>). These results indicated that the synovium graft on the conjunctiva had an effect on the qualitative and quantitative improvement of the tear film even though there was no histological change.
First Report of Zucchini yellow mosaic virus on Hollyhock (Althaea rosea)
Park, Won-Mok,Park, Seung-Kook,Yoon, Ju-Yeon,Ryu, Ki-Hyun,Park, Jang-Kyung The Korean Society of Plant Pathology 2002 Plant Pathology Journal Vol.18 No.3
This study was conducted to determine the causal virus that naturally infected hollyhock (Althaea rosea) plant showing mild mosaic symptom in 1999. Flexuous virus particles were found in the cytoplasm of plant tissue from infected hollyhock under transmissible electron microscopy. A virus from the genus Potyvirus under the family Potyviridae was isolated and was maintained on Chenopodium quinoa for three passages. Chlorotic local legions were used to inoculate 20 species of indicator plants. The virus infected all the tested cucurbit plants, but failed to infect Nicotiana benthamiana. Based on the host range test and RT-PCR analysis, the potyvirus was identified as a strain of Zucchini yellow mosaic virus-A (ZYMV-A), one of the major pathogens of cucurbits. Infectivity analysis showed that ZYMV-A induced faster systemic symptom than ZYMV-Cu on squash and other cucurbit plants, suggesting that ZYMV-A was a more severe strain. To better characterize ZYMV-A, Western blot assay was carried rout to the coat protein (CP) of the virus using ZYMV-specific antiserum with ZYMV-Cu and other potyviruses. The CP of the virus reacted strongly with the antiserum against ZYMV, and other tested antisera did not react with the CP of ZYMV-A. Results strongly suggest that the potyvirus infecting hollyhock was a novel strain of ZYMV. This is the first report on ZYMV as the causal virus infecting hollyhock in Korea.
Park, Kyung Sook,Kim, Yung Jin,Mok, Jee Won,Lee, Mi Hae 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-
한국인 383명의 Complement Componet 6(C6)의 유전적 다형을 등전점 전기영동과 immunoblotting으로 조사하였다. 5가지 allotypes, C6 A, C6 B, C6 B2, C6 M1, C6 M11이 나타났고, 이들의 대립유전인자 빈도는 C6^*A = 0.4399, C6^*B = 0.5144, C6^*B2 = 0.0392로 산출되어 이는 동아시아인과 비슷하였다. The phenotyping of the sixth complement component (C6) was performed on plasma or serum samples from 383 unrelated Korean, by IEF and immunoblotting using anti-human C6 serum. Three common allotypes, C6 A, C6 B and C6 B2 and two rare allotypes, C6 M1 and C6 M11 were observed. The allele frequencies of C6^*A, C6^*B and C6^*B2 were estimated to be 0.4399, 0.5144, 0.0392, respectively. These frequencies are similar to those of the Eastasian populations.
GENETIC STUDIES ON THE KOREAN POPULATION : 27. GENETIC POLYMORPHISM OF COMPLEMENT COMPONENT 8
PARK, KYUNG SOOK,KIM, YUNG JIN,MOK, JEE WON 충남대학교 기초과학연구소 1993 연구논문집 Vol.13 No.-
The genetic polymorphism of the C81(α-γ) subunits and C82(β) subunit of the eighth component of complement in 510 healthy unrelated Korean were investigated, using isoelectric focusing followed by immunoblotting. Three common and four rare phenotypes were observed in C81 locus. The allele frequencies for C81*A, C81*B, C81*A1, C81*B1 and C81*A2 were estimated to be 0.6294, 0.3588, 0.0069, 0.0020 and 0.0029, respectively. The gene frequencies of the common allele of C81 in Korean were similar to those for the other ethnic groups thus far reported. There were four phenotypes: C82A, C82AB, C82B and C8β chain null forms(C82AQ). The allele frequencies were estimated as follows: C82*A was 0.2255, C82*B was 0.7725 and C82*AQ was 0.0020. The distributions of C82 phenotypes and their respective allele frequencies were different from the data reported in Caucasian.
Park, Keum-Soo,Bae, Chang,Lee, Cheol-Won,Choie, Mok-Kyun CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
The present study was undertaken to investigate the effects of cryosurgery and scalpel excision of oral carcinoma induced by DMBA in hamster. The obtained results were as follows. 1. In the first experiment of oral carcinogenesis, hyperkeratosis and mild acanthosis occurred at 6 to 8 weeks, epithelial dysplasia and severe acanthosis at 8-10 weeks, carcinoma-in-situ at 10-12 weeks, papillary and frankly invasive carcinoma at 12-14 weeks, extensive tumors with invasion and surface necrosis at 14-16 weeks. 2. In comparison with the control group of carcinoma the experimental groups (both cryosurgery and scalpel excision group) showed the earlier development of invasive carcinoma with higher frequency and deeper penetration. 3. In the 2nd experiment of cryosurgery and scalpel excision, scalpel excision group showed the earlier development of invasive carcinoma than cryosurgery group.