http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
IRF7 promotes glioma cell invasion by inhibiting AGO2 expression.
Kim, Jun-Kyum,Jin, Xiong,Ham, Seok Won,Lee, Seon Yong,Seo, Sunyoung,Kim, Sung-Chan,Kim, Sung-Hak,Kim, Hyunggee Saikon Pub. Co 2015 TUMOR BIOLOGY Vol.36 No.7
<P>Interferon regulatory factor 7 (IRF7) is the master transcription factor that plays a pivotal role in the transcriptional activation of type I interferon genes in the inflammatory response. Our previous study revealed that IRF7 is an important regulator of tumor progression via the expression of inflammatory cytokines in glioma. Here, we report that IRF7 promotes glioma invasion and confers resistance to both chemotherapy and radiotherapy by inhibiting expression of argonaute 2 (AGO2), a regulator of microRNA biogenesis. We found that IRF7 and AGO2 expression levels were negatively correlated in patients with glioblastoma multiforme. Ectopic IRF7 expression led to a reduction in AGO2 expression, while depletion of IRF7 resulted in increased AGO2 expression in the LN-229 glioma cell line. In an in vitro invasion assay, IRF7 overexpression enhanced glioma cell invasion. Furthermore, reconstitution of AGO2 expression in IRF7-overexpressing cells led to decreased cell invasion, whereas the reduced invasion due to IRF7 depletion was rescued by AGO2 depletion. In addition, IRF7 induced chemoresistance and radioresistance of glioma cells by diminishing AGO2 expression. Finally, AGO2 depletion alone was sufficient to accelerate glioma cell invasion in vitro and in vivo, indicating that AGO2 regulates cancer cell invasion. Taken together, our results indicate that IRF7 promotes glioma cell invasion and both chemoresistance and radioresistance through AGO2 inhibition.</P>
Description of unrecorded bacterial species belonging to the phylum Actinobacteria in Korea
Kim, Mi-Sun,Kim, Seung-Bum,Cha, Chang-Jun,Im, Wan-Taek,Kim, Won-Yong,Kim, Myung-Kyum,Jeon, Che-Ok,Yi, Hana,Yoon, Jung-Hoon,Kim, Hyung-Rak,Seong, Chi-Nam The National Institute of Biological Resources 2021 Journal of species research Vol.10 No.1
For the collection of indigenous prokaryotic species in Korea, 77 strains within the phylum Actinobacteria were isolated from various environmental samples, fermented foods, animals and clinical specimens in 2019. Each strain showed high 16S rRNA gene sequence similarity (>98.8%) and formed a robust phylogenetic clade with actinobacterial species that were already defined and validated with nomenclature. There is no official description of these 77 bacterial species in Korea. The isolates were assigned to 77 species, 31 genera, 18 families, 14 orders and 2 classes of the phylum Actinobacteria. All the strains except one Coriobacteriia strain were affiliated within the class Actinomycetia. Among them, the orders Streptomycetales and Microbacteriales were predominant. A number of strains were isolated from forest soils, riverside soils, and ginseng cultivated soils. Twenty-nine strains were isolated from 'Protected Ecosystem and Scenery Areas'. Morphological properties, basic biochemical characteristics, isolation source and strain IDs are described in the species descriptions.
Microbial Conversion of Major Ginsenoside $Rb_1$ to Pharmaceutically Active Minor Ginsenoside Rd
Kim Myung Kyum,Lee Jun Won,Lee Ki Young,Yang Deok-Chun The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.5
More than seventy strains of aerobic bacteria showing ${\beta}$-glucosidase activity were isolated from a ginseng field, using a newly designed Esculin-R2A agar, and identified by their 16S rRNA gene sequences. Of these microorganisms, twelve strains could convert the major ginsenoside, $Rb_1$, to the pharmaceutically active minor ginsenoside Rd. Three strains, Burkholderia pyrrocinia GP16, Bacillus megaterium GP27 and Sphingomonas echinoides GP50, were phylogenetically studied, and observed to be most potent at converting ginsenoside $Rb_1$ almost completely within 48 h, as shown by TLC and HPLC analyses.
Unrecorded prokaryotic species belonging to the class Actinobacteria in Korea
Kim, Mi-Sun,Jeong, Seong-Hwa,Kang, Joo-Won,Kim, Seung-Bum,Cho, Jang-Cheon,Cha, Chang-Jun,Im, Wan-Taek,Bae, Jin-Woo,Lee, Soon-Dong,Kim, Won-Yong,Kim, Myung-Kyum,Seong, Chi-Nam The National Institute of Biological Resources 2019 Journal of species research Vol.8 No.1
For the collection of indigenous prokaryotic species in Korea, 35 strains within the class Actinobacteria were isolated from various environmental samples (animals and clinical specimens) in 2017. Each strain showed high 16S rRNA gene sequence similarity (>98.8%) and formed a robust clade with recognized actinobacterial species. The isolates were assigned to 35 species, 22 genera, 15 families, and 8 orders of the class Actinobacteria. There are no official descriptions of these 35 bacterial species in Korea. Morphological properties, basic biochemical characteristics, isolation source, and strain IDs are included in the species descriptions.
Kim, Won-Geun,Kim, Chang-Kyum,Lee, Jong-Tae,Kim, Jeong-Soo,Yun, Chang-Wan,Yook, Se-Jin Pergamon 2017 Transportation Research Part D. Transport & Enviro Vol.53 No.-
<P><B>Abstract</B></P> <P>The characteristics of fine particle emission from a light-duty diesel vehicle operated on a chassis dynamometer were investigated according to vehicle acceleration and road grade. Particle number (PN) concentration and particle mass (PM) concentration were measured using a Solid Particle Counting System (SPCS), an Engine Exhaust Particle Sizer (EEPS), and a Dekati Low Pressure Impactor (DLPI). In this study, actual mass distribution of particles emitted from the tested diesel vehicle was determined by sampling the particles on 25-mm Teflon-coated filters installed at 13 impactor stages of the DLPI and then compared with the particle mass distribution converted from the particle number distribution measured by the EEPS. In order to evaluate the characteristics of fine particle emission under various conditions of vehicle acceleration and road grade, testing was conducted with or without installing a Diesel Particulate Filter (DPF). In general, PN and PM concentrations increased with both increasing vehicle acceleration and increasing road grade.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fine particle emission characteristics of a light-duty diesel vehicle were examined. </LI> <LI> A diesel vehicle was operated at various vehicle accelerations and road grades. </LI> <LI> Actual mass distribution of particles emitted from test diesel vehicle was obtained. </LI> <LI> Mass concentration increased as both vehicle acceleration and road grade increased. </LI> </UL> </P>
Kim, In-Kyum,Chin, Young-Won,Lim, Song-Won,Kim, Young-Choong,Kim, Jin-Woong The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.6
(+)-Dehydrovomifoliol (1). 3-hydroxy-5$\alpha$,6$\alpha$-epoxy-$\beta$-ionone (2), vitexin 7 -O-$\beta$-D-glucopyrano-side (3), and vitexin 2'-O-$\beta$-D-glucopyranoside (4) were isolated as new constituents from the aerial parts of Beta vulgaris var. cicla. Compounds 3 and 4 demonstrated hepatoprotective activity with values of 65.8 and 56.1%, respectively, in primary cultured rat hepatocytes with $CCl_4$-induced cell toxicity, compared to controls. This was comparable to that of silibinin (69.8%) which was used as a positive control.trol.