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Non-asymptotic model quality assessment of transfer functions at multiple frequency points
Ko, Sangho,Weyer, Erik,Campi, Marco Claudio Elsevier 2015 Automatica Vol.60 No.-
<P>In this paper we develop methods for evaluating uncertainties in the frequency response of a dynamical system based on finitely many input output data points. We extend the 'Leave-out Sign-dominant Correlation Regions' (LSCR) algorithm to deliver confidence regions with a guaranteed probability for the frequency response at multiple frequencies, and we introduce a computationally efficient scheme that enables the confidence regions to be constructed frequency by frequency. Simulation examples illustrating the usefulness of the developed algorithm are provided. (C) 2015 Elsevier Ltd. All rights reserved.</P>
Park, Y.,Hong, Y. N.,Weyers, A.,Kim, Y. S.,Linhardt, R. J. IET 2011 IET nanobiotechnology Vol.5 No.3
<P>Currently, sustainability initiatives that use green chemistry to improve and/or protect our global environment are becoming focal issues in many fields of research. Instead of using toxic chemicals for the reduction and stabilisation of metallic nanoparticles, the use of various biological entities has received considerable attention in the field of nanobiotechnology. Among the many possible natural products, polysaccharides and biologically active plant products represent excellent scaffolds for this purpose. Polysaccharides have hydroxyl groups, a hemiacetal reducing end, and other functionalities that can play important roles in both the reduction and the stabilisation of metallic nanoparticles. Among the various categories of compounds in plants that have potent biological activities, phytochemicals are emerging as an important natural resource for the synthesis of metallic nanoparticles. The focus of this review is the application of polysaccharides and phytochemicals in the green synthesis of gold and silver nanoparticles to afford biocomposites with novel uses in nanomedicine and as nanocomposites.</P>
Cardiotoxicity of Mitoxantrone Treatment in a German Cohort of 639 Multiple Sclerosis Patients
Vinzenz Fleischer,Anke Salmen,Susanne Kollar,Veronika Weyer,Volker Siffrin,Andrew Chan,Frauke Zipp,Felix Luessi 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background and Purpose The aim of this study was to elucidate the role of therapy-relatedcardiotoxicity in multiple sclerosis (MS) patients treated with mitoxantrone and to identify potential predictors for individual risk assessment. Methods Within a multicenter retrospective cohort design, cardiac side effects attributed tomitoxantrone were analyzed in 639 MS patients at 2 MS centers in Germany. Demographic,disease, treatment, and follow-up data were collected from hospital records. Patients regularlyreceived cardiac monitoring during the treatment phase. Results None of the patients developed symptomatic congestive heart failure. However, thefrequency of patients experiencing cardiac dysfunction of milder forms after mitoxantronetherapy was 4.1% (26 patients) among all patients. Analyses of the risk for cardiotoxicity revealed that cumulative dose exposure was the only statistically relevant risk factor associatedwith cardiac dysfunction. Conclusions The number of patients developing subclinical cardiac dysfunction below themaximum recommended cumulative dose is higher than was initially assumed. Interestingly, asubgroup of patients was identified who experienced cardiac dysfunction shortly after initiationof mitoxantrone and who received a low cumulative dose. Therefore, each administration ofmitoxantrone should include monitoring of cardiac function to enhance the treatment safety forpatients and to allow for early detection of any side effects, especially in potential high-risksubgroups (as determined genetically).
System Identification and Control of the Broken River
Foo, Mathias,Su Ki Ooi,Weyer, Erik Institute of Electrical and Electronics Engineers 2014 IEEE transactions on control systems technology Vol. No.
<P>In this paper, control system designs are proposed for the Broken River in Victoria, Australia. The aim of the control system is to improve water resource management and operation for the benefit of irrigators and the environment. Both centralized and decentralized control schemes are considered. The decentralized scheme consists of a number of PI and I controllers, while the centralized scheme is a model predictive controller. The controllers are designed based on simple models obtained using system identification methods. In a realistic simulation scenario, the control systems compared very favorably with current manual operation offering increased operational flexibility with a significant potential for substantial water savings, improved level of service to irrigators, and improved environmental benefits.</P>
Δ additive and Δ ultra-additive maps, Gromov's trees, and the Farris transform
Dress, A.,Holland, B.,Huber, K.T.,Koolen, J.H.,Moulton, V.,Weyer-Menkhoff, J. Elsevier 2005 Discrete Applied Mathematics Vol.146 No.1
<P><B>Abstract</B></P><P>In phylogenetic analysis, one searches for phylogenetic trees that reflect observed similarity between a collection of species in question. To this end, one often invokes two simple facts: (i) Any tree is completely determined by the metric it induces on its leaves (which represent the species). (ii) The resulting metrics are characterized by their property of being <I>additive</I> or, in the case of dated rooted trees, <I>ultra-additive</I>. Consequently, searching for additive or ultra-additive metrics <I>A</I> that best approximate the metric <I>D</I> encoding the observed similarities is a standard task in phylogenetic analysis. Remarkably, while there are efficient algorithms for constructing optimal ultra-additive approximations, the problem of finding optimal additive approximations in the <SUB>l1</SUB> or <SUB>l∞</SUB> sense is NP-hard. In the context of the theory of δ-<I>hyperbolic</I> groups, however, good additive approximations <I>A</I> of a metric <I>D</I> were found by Gromov already in 1988 and shown to satisfy the bound∥D-A<SUB>∥∞</SUB>⩽Δ(D)⌈<SUB>log2</SUB>(#X-1)⌉,where Δ(D), the <I>hyperbolicity</I> of <I>D</I>, i.e. the maximum of all expressions of the formD(u,v)+D(x,y)-max(D(u,x)+D(v,y),D(u,y)+D(v,x))(u,v,x,y∈X). Yet, besides some notable exceptions (e.g. Adv. Appl. Math. 27 (2001) 733–767), the potential of Gromov's concept of hyperbolicity is far from being fully explored within the context of phylogenetic analysis. In this paper, we provide the basis for a systematic theory of Δ <I>ultra-additive</I> and Δ <I>additive</I> approximations. In addition, we also explore the average and worst case behavior of Gromov's bound.</P>