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Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation
Thornton, Janet L.,Westfield, Gerwin H.,Takahashi, Yoh-hei,Cook, Malcolm,Gao, Xin,Woodfin, Ashley R.,Lee, Jung-Shin,Morgan, Marc A.,Jackson, Jessica,Smith, Edwin R.,Couture, Jean-Francois,Skiniotis, G Cold Spring Harbor Laboratory Press 2014 Genes & development Vol.28 No.2
<P>The stimulation of H3K4 trimethylation (H3K4me3) by H2B monoubiquitination (H2Bub) has been widely studied, and multiple mechanisms have been proposed for this form of histone cross-talk. Thornton et al. combine biochemical, structural, and in vivo approaches to provide a novel mechanism for the role of H2B ubiquitination machinery in the regulation of histone H3K4 methylation by COMPASS. This study demonstrates that the H2Bub machinery and Cps35/Swd2 function to focus the H3K4me3 activity of COMPASS at promoter-proximal regions in a context-dependent manner.</P>