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Flexible and Highly Sensitive Piezoresistive Pressure Sensor with Sandpaper as a Mold
Wendan Jia,Qiang Zhang,Yongqiang Cheng,Dong Zhao,Yan Liu,Wendong Zhang,Shengbo Sang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.7
Flexible pressure sensors based on piezoresistive induction have recently become a research hotspot due to the simple device structure, low energy consumption, easy readout mechanism and excellent performance. For practical applications, flexible pressure sensors with both high sensitivity and low-cost mass production are highly desirable. Herein, this paper presents a high-sensitivity piezoresistive pressure sensor based on a micro-structured elastic electrode, which is low cost and can be mass-produced by a simple method of sandpaper molding. The microstructure of the electrode surface under external pressure causes a change in the effective contact area and the distance between the electrodes, which exhibits great pressure sensitivity. The test results show that the surface structure is twice as sensitive as the planar structure under low pressure conditions. This is because of the special morphology of silver nanowires (AgNWs), which exhibits the tip of nanostructures on the surface and realizes the quantum tunneling mechanism. The sensor has high sensitivity for transmitting signals in real time and it can also be used to detect various contact actions. The low cost mass production and high sensitivity of flexible pressure sensors pave the way for electronic skin, wearable healthcare monitors and contact inspection applications.
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Wendan Xu,김지원,정우준,고영일,윤성수 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2
Purpose Anaplastic large cell lymphoma (ALCL) is a rare aggresive non-Hodgkin lymphoma, of which over 50% of cases have an aberrant nucleophosmin (NPM)anaplastic lymphoma kinase (ALK) fusion protein. Both mechanistic target of rapamycin (mTOR) inhibitor everolimus and ALK inhibitor crizotinib have shown promising antitumor activity in ALK-positive cancer cell lines. However, their combined effect has not yet been investigated. Materials and Methods We evaluated the anti-proliferative effects of everolimus and/or crizotinib in ALK-positive ALCL cell lines, Karpas 299 and SU-DHL-1, and lung adenocarcinoma cell line, NCI-H2228. Results We found that individually, both everolimus and crizotinib potently inhibited cell growth in a dose-dependent manner in both Karpas 299 and SU-DHL-1 cells. A combination of these agents synergistically inhibited proliferation in the two cell lines. Crizotinib down-regulated aberrant AKT and ERK phosphorylation induced by everolimus. Combination treatment also significantly increased G0/G1 cell-cycle arrest, DNA damage, and apoptosis compared with everolimus or crizotinib alone in ALK-positive ALCL cells. In the Karpas 299 xenograft model, the combination treatment exerted a stronger antitumor effect than monotherapies, without significant change in body weight. The synergistic effect of everolimus and crizotinib was also reproduced in the ALK-positive lung adenocarcinoma cell line NCI-H2228. The combination treatment abrogated phosphoinositide 3-kinase/AKT and mTOR signaling pathways with little effect on the Ras/ERK pathway in NCI-H2228 cells. Conclusion Crizotinib combined with everolimus synergistically inhibits proliferation of ALK-positive ALCL cells. Our results suggest that this novel combination is worthy of further clinical development in patients with ALK-positive ALCL.
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Ying Tang,Shuyan Yang,Wendan He,Lei Liu,Zhongfei Zhang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.6
Chinese gallnut (Galla chinensis) is rich in hydrolyzable tannins, which, when mordanted with ferrous ions,produces intense black color on keratinous fiber and makes it a desirable natural hair dye in Asian countries. However,extracted tannins from Chinese gallnut are susceptible to chemical degradation by physicochemical factors (heat, UV, andhigh pH) that limited the utilization and commercialization of this plant colorant in color cosmetics. Hence, this study wasaimed to improve the storage and application stability of Chinese gallnut extract by spray-drying microencapsulation. Different combinations of maltodextrin (MD) and gum arabic (GA) were used as encapsulating agents and the effects on theencapsulation efficiency, morphology, physicochemical properties, in vitro toxicity, and stability were investigated. Theresults showed that an increase of MD proportions in the wall matrix resulted in the production of more spherical shapedparticles with larger size, decreased bulk density, and improved solubility in water. Furthermore, microcapsules covered withMD alone showed the maximum stability with respect to heat, UV, and formulation at alkaline pH. When applied for dyeingof human gray hairs, intense black color could be achieved by using the MD-covered microcapsule formulations and thedyeings are stable to multiple washings and simulated sunlight. Therefore, this study examines a promising strategy forstabilizing tannin-rich extract from Chinese gallnut while maintaining its dyeing efficiency, which will in turn promote itsutilization in hair coloring cosmetics.
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