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        COORDINATED COLLISION AVOIDANCE FOR CONNECTED VEHICLES USING RELATIVE KINETIC ENERGY DENSITY

        Manjiang Hu,Jian Wu,Hongmao Qin,Yougang Bian,Biao Xu,Qing Xu,Jugang He,Jianqiang Wang 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.5

        Vehicular collision often leads to serious casualties and traffic congestion, and the consequences are worse for multiple-vehicle collision. Many previous works on collision avoidance have only focused on the case for two consecutive vehicles using on-board sensors, which ignored the influence on upstream traffic flow. This paper proposes a novel coordinated collision avoidance (CCA) strategy for connected vehicles, which has potential to avoid collision and smooth the braking behaviors of multiple vehicles, leading to an improvement of traffic smoothness. Specifically, model predictive control (MPC) framework is used to formulate the CCA into an optimization problem, where the objective is to minimize the total relative kinetic energy density (RKED) among connected vehicles. Monte Carlo simulations are used to demonstrate the effectiveness of proposed CCA strategy by comparison with other two strategies. Among all the three control strategies, the RKED based control strategy shows the best performance of collision avoidance, including the best crash prevention rates (99.2 % on dry asphalt road and 90.5 % on wet asphalt road) and the best control of distance headways between vehicles.

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        Se improves GPX4 expression and SOD activity to alleviate heat-stress-induced ferroptosis-like death in goat mammary epithelial cells

        Liu Lu,Wang Manjiang,Gong Ning,Tian Peng,Deng Hongxia 한국통합생물학회 2021 Animal cells and systems Vol.25 No.5

        Selenium (Se) is a vital element of life, which has an important impact on the growth, development, production performance and stress-tolerance of animals. However, it is not entirely clear that how exactly Se works during these processes. Herein, we investigate the role of Se in regulating the functions of goat mammary epithelial cells (GMECs) under heat-stress condition. We found that heat stress caused ferroptosis-like death in GMECs, manifested by a robust increase in iron ion concentration, reactive oxygen species (ROS) and cell death ratio, and a decrease in the activity of superoxide dismutase (SOD) and expression level of glutathione peroxidases 4 (GPX4). Se incubation had no obvious effect on GMEC viability, but alleviated heat-stress-induced ferroptosis-like cell death and improved GPX4 expression and SOD activity in a dose-dependent manner. Also, we found that overexpression of GPX4 could improve the activity of SOD. And Se incubation inhibited activation of mTOR signaling in heat-stress-induced GMECs, which could be eliminated by the mTOR activator MHY1485, and treatment with mTOR inhibitor AY-22989 had the same effect as Se. In conclusion, Se improves GPX4 expression and SOD activity and inhibits the activation of mTOR to alleviate heatstress- induced ferroptosis-like death in GMECs, whichmay be a protective agent for heat stress in goats.

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