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RISS 인기검색어
- 검색키워드
- 저자 : Waclaw, R. R. (검색결과 3 건)
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Krzysztof Magnucki,Pawel Jasion,Waclaw Szyc,Mikolaj Jan Smyczynski 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.16 No.3
The strength and buckling problem of a five layer sandwich beam under axial compression or bending is presented. Two faces of the beam are thin aluminium sheets and the core is made of aluminium foam. Between the faces and the core there are two thin binding glue layers. In the paper a mathematical model of the field of displacements, which includes a share effect and a bending moment, is presented. The system of partial differential equations of equilibrium for the five layer sandwich beam is derived on the basis of the principle of stationary total potential energy. The equations are analytically solved and the critical load is obtained. For comparison reasons a finite element model of the beam is formulated. For the case of bended beam the static analysis has been performed to obtain the stress distribution across the height of the beam. For the axially compressed beam the buckling analysis was carried out to determine the buckling load and buckling shape. Moreover, experimental investigations are carried out for two beams. The comparison of the results obtained in the analytical and numerical (FEM) analysis is shown in graphs and figures. The main aim of the paper is to present an analytical model of the five layer beam and to compare the results of the theoretical, numerical and experimental analyses.
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Jeong, Y.,Dolson, D. K.,Waclaw, R. R.,Matise, M. P.,Sussel, L.,Campbell, K.,Kaestner, K. H.,Epstein, D. J. The Company of Biologists 2011 Development (Cambridge) Vol.138 No.3
<P>In caudal regions of the diencephalon, sonic hedgehog (Shh) is expressed in the ventral midline of prosomeres 1-3 (p1-p3), which underlie the pretectum, thalamus and prethalamus, respectively. Shh is also expressed in the zona limitans intrathalamica (zli), a dorsally projecting spike that forms at the p2-p3 boundary. The presence of two Shh signaling centers in the thalamus has made it difficult to determine the specific roles of either one in regional patterning and neuronal fate specification. To investigate the requirement of Shh from a focal source of expression in the ventral midline of the diencephalon, we used a newly generated mouse line carrying a targeted deletion of the 525 bp intronic sequence mediating Shh brain enhancer-1 (SBE1) activity. In SBE1 mutant mice, Shh transcription was initiated but not maintained in the ventral midline of the rostral midbrain and caudal diencephalon, yet expression in the zli was unaffected. In the absence of ventral midline Shh, rostral thalamic progenitors (pTH-R) adopted the molecular profile of a more caudal thalamic subtype (pTH-C). Surprisingly, despite their early mis-specification, neurons derived from the pTH-R domain continued to migrate to their proper thalamic nucleus, extended axons along their normal trajectory and expressed some, but not all, of their terminal differentiation markers. Our results, and those of others, suggest a model whereby Shh signaling from distinct spatial and temporal domains in the diencephalon exhibits unique and overlapping functions in the development of discrete classes of thalamic interneurons.</P>
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Development of Creatine and Arginine-6-Oligomer for the Ring-Opening Polymerization of Cyclic Esters
Ewa Oledzka,Marcin Sobczak,Mateusz Kolakowski,Bartlomiej Kraska,Wojciech Kamysz,Waclaw Kolodziejski 한국고분자학회 2013 Macromolecular Research Vol.21 No.2
Natural creatine and arginine-6-oligomer have been effectively engaged as ring-opening polymerization initiators of poly(L-lactide) (PLLA) and poly(ε-caprolactone) (PCL) in bulk. The nonlinear structure and thermal properties of the resulted polymers were further elucidated by 1H, 13C nuclear magnetic resonance, and a modulated differencial scanning calorimetry (MDSC). Thermal analysis indicated that the synthesized polymers had lower melting points, glass-transition temperatures, fusion enthalpy, and crystallization temperature than those of linear PCL or PLLA due to the presence of the arginine-6-oligomer in the macromolecule and crystalline imperfections caused by the branched structure. This study provides an efficient and metal-free method for the synthesis of branched biodegradable polymers with incorporated compounds, which exhibit therapeutic properties, adequate for the drug carrier applications.
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