Application of Linear Programming for cassava starch production optimization in Vietnam within a Circular Economy framework toward Zero emission

Vo Van Giau,Tran Van Thanh,Tran Le Luu,Hans Schnitzer,Le Thanh Hai 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.4

Cassava starch production is a key industrial production of Tay Ninh province, Vietnam. However, this production chain has also caused many negative impacts on the environment. This study applied the principles of circular economy to analyze the waste streams via linear programming method for cassava starch circular production chain towards zero waste emission. The results show that the cassava starch indutry can achieve the goals of zero electricity, zero waste, and zero fossil energy by re-planning the production chain. The chain’s output products are 517.5 tons of bio-oil/year, 206.7 thousand tons of biochar/year, 190.0 thousand tons of dry pulp/year, 10 million m³/year of liquid fertilizer. In order to increase further the value of the chain in the circular economy, future research needs to study the feasibility of a solution to reuse wastewater to produce microalgae, as well as evaluate the effectiveness of these methods. The optimization method applied in this study can also be extended to similar agricultural chains properties such as rice processing, sugar cane, etc.

Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages

( Van Anh Vo ),( Jae Won Lee ),( Ji Eun Chang ),( Ji Young Kim ),( Nam Ho Kim ),( Hee Jae Lee ),( Sung Soo Kim ),( Wan Joo Chun ),( Yong Soo Kwon ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.6

Avicularin, quercetin-3-a-L-arabinofuranoside, has been reported to possess diverse pharmacological properties such as anti-in-flammatory and anti-infectious effects. However, the underlying mechanism by which avicularin exerts its anti-inflammatory activity has not been clearly demonstrated. This study aimed to elucidate the anti-inflammatory mechanism of avicularin in lipopolysac-charide (LPS)-stimulated RAW 264.7 macrophage cells. Avicularin significantly inhibited LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2 and the protein levels of iNOS and COX-2, which are responsible for the production of NO and PGE2, respectively. Avicularin also suppressed LPS-induced overproduction of pro-inflammatory cytokine IL-1b. Furthermore, avicularin significantly suppressed LPS-induced degradation of IκB, which retains NF-κB in the cytoplasm, consequently inhibiting the transcription of pro-inflammatory genes by NF-κB in the nucleus. To understand the un-derlying signaling mechanism of anti-inflammatory activity of avicularin, involvement of multiple kinases was examined. Avicularin significantly attenuated LPS-induced activation of ERK signaling pathway in a concentration-dependent manner. Taken together, the present study clearly demonstrates that avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells.

Regional Culture, Ethnic Culture and The Socio-Economic Development of The Mekong Delta

Vo Van Sen,Phan Van Dop 국제지역연구학회 2014 국제지역학논총 Vol.7 No.2

This paper is to investigate the current cultural and socioecomonic situation of the rural Mekong Delta in South Vietnam under the impact of the processes of modernization and urbanization. As a matter fact, Mekong Delta is the lately-founded land, land of multiculturalism, has maintained its old-style agricultural farming experience and not been ready to transform under the new waves of economy. In addition, the inadequate investigation from the central government has partially isolated this region from modernizing the local society. As a result, the standstill standard of living, the debt-enduring situation have pushed some of the households in harsh conditions, some seem to be stuck to manage, the others have to adopt unhealthy way to overcome the situation. From a long-term fieldwork research, the paper has primarily offered the scientific evidences for the adequate and effective policies which may be published for the change in Mekong Delta.

Methyl p-Hydroxycinnamate Suppresses Lipopolysaccharide-Induced Inflammatory Responses through Akt Phosphorylation in RAW264.7 Cells

( Van Anh Vo ),( Jae Won Lee ),( Seung Yeon Shin ),( Jae Hyun Kwon ),( Hee Jae Lee ),( Sung Soo Kim ),( Yong Soo Kwon ),( Wan Joo Chun ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.1

Derivatives of caffeic acid have been reported to possess diverse pharmacological properties such as anti-inflammatory, anti-tumor, and neuroprotective effects. However, the biological activity of methyl p-hydroxycinnamate, an ester derivative of caffeic acid, has not been clearly demonstrated. This study aimed to elucidate the anti-inflammatory mechanism of methyl p-hydroxycinnamate in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Methyl p-hydroxycinnamate significantly inhibited LPSinduced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2 and the protein expression of iNOS and COX-2. Methyl p-hydroxycinnamate also suppressed LPS-induced overproduction of pro-inflammatory cytokines such as IL-1b and TNF-a. In addition, methyl p-hydroxycinnamate significantly suppressed LPS-induced degradation of IκB, which retains NF-κB in the cytoplasm, consequently inhibiting the transcription of pro-inflammatory genes by NF-κB in the nucleus. Methyl p-hydroxycinnamate exhibited significantly increased Akt phosphorylation in a concentration-dependent manner. Furthermore, inhibition of Akt signaling pathway with wortmaninn abolished methyl p-hydroxycinnamate-induced Akt phosphorylation. Taken together, the present study clearly demonstrates that methyl p-hydroxycinnamate exhibits anti-inflammatory activity through the activation of Akt signaling pathway in LPS-stimulated RAW264.7 macrophage cells.

Effective Elimination of Charge-associated Toxicity of Low Generation Polyamidoamine Dendrimer Eases Drug Delivery of Oxaliplatin

Vo Minh Hoang Do,Long Giang Bach,Diem-Huong Nguyen Tran,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen,Thai Thanh Hoang Thi 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2

Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of unsatisfied drug release, high tendency of interfering with cellular membranes, and rapid clearance by reticuloendothelial system. In this study, low generation polyamidoamine (PAMAM) dendrimer G3.0 is developed and surface modified with methoxypolyethylene glycol (PAMAM G3.0-mPEG) to overcome its limitations. Specifically, PAMAM G3.0 conjugated with mPEG at different ratios are investigated to effectively eliminate its charge-associated toxicity, in which PAMAM G3.0-mPEG- 8 is chosen for oxaliplatin (OX) loading. Results reveal that OX-loaded PAMAM G3.0-mPEG-8 has desirable size, good entrapment efficiency, and sustained release with minimum drug leakage. In addition, Resazurin assay indicates that the toxicity of loaded OX is reduced as compared to free drug but still maintain substantially anticancer activity on HeLa cells, suggesting the potential application of PAMAM G3.0-mPEG-8 for OX delivery in cancer therapy.

Ag-deposited Porous Silicon as a SERS-active Substrate for the Sensitive Detection of Catecholamine Neurotransmitters

Van-The Vo,Youngju Gwon,Viet-Duc Phung,Young-Don Son,Jong-Hoon Kim,Sang-Wha Lee 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.3

The sensitive detection of various neurotransmitters is very useful in diagnosing diseases related to the dysfunction of theneurotransmitter system. Surface-enhanced Raman scattering (SERS) is one of the best methods for bio-analyte detectionas it provides a molecular fi ngerprint at a trace concentration level. In this study, Ag-deposited porous silicon (Ag@pSi)was fabricated as a SERS-active substrate via metal-assisted chemical etching and electroless plating methods. Dopamine(DA) and norepinephrine (NE) neurotransmitters were tested as probing analytes. The Ag@pSi substrate demonstrated thesensitive detection of the neurotransmitters (DA and NE) over the wide concentration range (from 10 6 to 10 10 M), witha good linearity between the intensity of specifi c Raman peak and the log-scale concentration. The Ag@pSi substrate alsodistinguished the individual analytes in a mixture of DA and NE at 10 8 M, confi rming the effi cacy of the developed SERSsubstrate for the selective detection of neurotransmitters.

Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl ${\beta}$-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells

Vo, Van Anh,Lee, Jae-Won,Kim, Ji-Young,Park, Jun-Ho,Lee, Hee Jae,Kim, Sung-Soo,Kwon, Yong-Soo,Chun, Wanjoo The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.1

Hydroxycinnamic acids have been reported to possess numerous pharmacological activities such as antioxidant, anti-inflammatory, and anti-tumor properties. However, the biological activity of 1-p-coumaroyl ${\beta}$-D-glucoside (CG), a glucose ester derivative of p-coumaric acid, has not been clearly examined. The objective of this study is to elucidate the anti-inflammatory action of CG in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. In the present study, CG significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and $PGE_2$ and the protein expression of iNOS and COX-2. CG also inhibited LPS-induced secretion of pro-inflammatory cytokines, IL-$1{\beta}$ and TNF-${\alpha}$. In addition, CG significantly suppressed LPS-induced degradation of $I{\kappa}B$. To elucidate the underlying mechanism by which CG exerts its anti-inflammatory action, involvement of various signaling pathways were examined. CG exhibited significantly increased Akt phosphorylation in a concentration-dependent manner, although MAPKs such as Erk, JNK, and p38 appeared not to be involved. Furthermore, inhibition of Akt/PI3K signaling pathway with wortmannin significantly, albeit not completely, abolished CG-induced Akt phosphorylation and anti-inflammatory actions. Taken together, the present study demonstrates that Akt signaling pathway might play a major role in CG-mediated anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells.

DIFFUSION IN SIMULATED SiO2 NANOPARTICLES

VO VAN HOANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.5

Diffusion in liquid SiO2 nanoparticle with the diameter of 4 nm has been studied in a spherical model containing 2214 atoms via Molecular Dynamics simulation (MD). Diffusion constant of atomic species has been calculated over temperatures ranged from 2100 K to 7000 K and compared with those observed for the bulk. We found that temperature dependence of diffusion constant of atomic species in nanoparticle shows an Arrhenius law at temperatures above 2100 K and at T > 4200 K, it deviates from an Arrhenius law. However, unlike those observed in the bulk at T > 4200 K, it does not show a power law, D ~ (T - Tc)γ. Moreover, at relatively low temperatures, diffusion constant in nanoparticle is higher than that in the bulk indicating the surface dynamics effects.

N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells

( Van Anh Vo ),( Jae Won Lee ),( Jun Ho Park ),( Jae Hyun Kwon ),( Hee Jae Lee ),( Sung Soo Kim ),( Yong Soo Kwon ),( Wan Joo Chun ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.3

N-(p-Coumaryol) tryptamine (CT), a phenolic amide, has been reported to exhibit anti-oxidant and anti-inflammatory activities. However, the underlying mechanism by which CT exerts its pharmacological properties has not been clearly demonstrated. The objective of this study is to elucidate the anti-inflammatory mechanism of CT in lipopolysaccharide (LPS)-challenged RAW264.7 macrophage cells. CT significantly inhibited LPS-induced extracellular secretion of pro-inflammatory mediators such as nitric oxide (NO) and PGE2, and protein expressions of iNOS and COX-2. In addition, CT significantly suppressed LPS-induced secretion of pro-inflammatory cytokines such as TNF-a and IL-1b. To elucidate the underlying anti-inflammatory mechanism of CT, involvement of MAPK and Akt signaling pathways was examined. CT significantly attenuated LPS-induced activation of JNK/c-Jun, but not ERK and p38, in a concentration-dependent manner. Interestingly, CT appeared to suppress LPS-induced Akt phosphorylation. However, JNK inhibition, but not Akt inhibition, resulted in the suppression of LPS-induced responses, suggesting that JNK/c- Jun signaling pathway significantly contributes to LPS-induced inflammatory responses and that LPS-induced Akt phosphorylation might be a compensatory response to a stress condition. Taken together, the present study clearly demonstrates CT exerts antiinflammatory activity through the suppression of JNK/c-Jun signaling pathway in LPS-challenged RAW264.7 macrophage cells.

Structural defects and thermodynamics of vitreous GeO_2 nanoparticles

Vo Van Hoang,Tran Phuoc Duy 한국물리학회 2011 Current Applied Physics Vol.11 No.3

Structural defects and thermodynamics of vitreous GeO_2 nanoparticles have been studied in spherical models of different sizes ranged from 2 to 5 nm. Models have been obtained by cooling from the melts via using molecular dynamics (MD) method with the ab initio pair interatomic potentials. Structural properties were investigated via partial radial distribution function (PRDF), interatomic distances, bondangle and coordination number distributions. Surface and core structure of amorphous GeO_2 nanoparticles have been studied in details. Structural defects and their role in structure and properties of nanoparticles have been analyzed and discussed. We found temperature (and size) dependence of potential energy, surface energy of GeO_2 nanoparticles. We also found the size dependence of glass transition temperature of nanoparticles.