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Non-Surgical Management of Gastroduodenal Fistula Caused by Ingested Neodymium Magnets
Claudia Phen,Alexander Wilsey,Emily Swan,Victoria Falconer,Lisa Summers,Michael Wilsey 대한소아소화기영양학회 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.4
Foreign body ingestions pose a significant health risk in children. Neodymium magnets are high-powered, rare-earth magnets that is a serious issue in the pediatric population due to their strong magnetic force and high rate of complications. When multiple magnets are ingested, there is potential for morbidity and mortality, including gastrointestinal fistula formation, obstruction, bleeding, perforation, and death. Many cases require surgical intervention for removal of the magnets and management of subsequent complications. However, we report a case of multiple magnet ingestion in a 19-month-old child complicated by gastroduodenal fistula that was successfully treated by endoscopic removal and supportive care avoiding the need for surgical intervention. At two-week follow-up, the child was asymptomatic and upper gastrointestinal series obtained six months later demonstrated resolution of the fistula.
Non-Surgical Management of Gastroduodenal Fistula Caused by Ingested Neodymium Magnets
Phen, Claudia,Wilsey, Alexander,Swan, Emily,Falconer, Victoria,Summers, Lisa,Wilsey, Michael The Korean Society of Pediatric Gastroenterology 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.4
Foreign body ingestions pose a significant health risk in children. Neodymium magnets are high-powered, rare-earth magnets that is a serious issue in the pediatric population due to their strong magnetic force and high rate of complications. When multiple magnets are ingested, there is potential for morbidity and mortality, including gastrointestinal fistula formation, obstruction, bleeding, perforation, and death. Many cases require surgical intervention for removal of the magnets and management of subsequent complications. However, we report a case of multiple magnet ingestion in a 19-month-old child complicated by gastroduodenal fistula that was successfully treated by endoscopic removal and supportive care avoiding the need for surgical intervention. At two-week follow-up, the child was asymptomatic and upper gastrointestinal series obtained six months later demonstrated resolution of the fistula.
Salez M. Agustina,González Javier M.,Bernacchini Joana C.,Rodriguez M. Victoria,Ferreyra M. Lorena Falcone,Casati Paula,Rius Sebastián P. 한국식물학회 2022 Journal of Plant Biology Vol.65 No.6
Flavonoids are polyphenolic compounds and color most flowers, fruits and seeds. The regulation of flavonoid biosynthetic genes is directed by ternary complexes composed of MYB-bHLH-WD40 transcription factors. DNA-binding bHLH proteins are widely distributed in higher plants and comprise the second largest transcription factor family. The regulation of flavonoid synthesis by bHLH has been extensively studied in vascular plants, most functionally characterized in Arabidopsis. Sorghum is one of the most economically important crops worldwide. Despite 169 bHLH genes were identified in this cereal, few studies have reported their roles in seed coat pigmentation. Here we identified and characterized SbTT8, a sorghum bHLH-domain protein, through molecular modeling and complementation studies in Arabidopsis tt8 mutant. SbTT8 partially rescues the brown seed color and dormancy in Arabidopsis tt8 mutants. We show that SbTT8 is significantly larger than AtTT8 and holds a Lys467 residue where AtTT8 has an Ala367, within the DNA-recognition motif conserved throughout the bHLH family. This change likely affects how SbTT8 interacts with the target DNA, as compared with AtTT8. Our results shed light on the different phenotypes witnessed for A. thaliana transgenic lines expressing SbTT8 from sorghum, as well as the regulation of genes encoding enzymes for flavonoid biosynthesis.