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- 저자 : Veronica Natalia (검색결과 2 건)
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Veronica Natalia,Loh Yi Ying,Loh Lydia Xiu Ying,Heng Paul Wan Sia,Liew Celine Valeria 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose This study aimed to elucidate the effects magnesium stearate (MgSt) with different physical properties have on powder flow and tablet physical properties. The effects of variation in MgSt chemical properties were also investigated with a focus on the palmitate to stearate (C16/C18) ratio. Methods Lactose blended with 0.25, 0.5 and 1%, w/w of different MgSt grades were evaluated for flow properties. Tablets produced from the mixtures were assessed for tensile strength and ejection force. Results Pearson correlation analysis of high C16/C18 ratio (1.09–1.29) MgSt suggested that increasing C16/C18 ratio could improve flowability and reduce tablet mechanical strength. For low C16/C18 ratio (0.41–0.53) MgSt, increasing C16/C18 ratio only resulted in better flowability. Multivariate analysis showed that the MgSt properties influenced the flowability and tablet physical properties of formulations containing 1%, w/w MgSt. The C16/C18 ratio affected flowability. However, its effect was confounded by MgSt particle size, morphology, crystallinity, and moisture content. Contrastingly, tablet tensile strength was mainly influenced by MgSt particle size, crystallinity, and moisture content, while tablet ejection force was minimally affected by the MgSt properties. Conclusion While the C16/C18 ratio could affect the powder flow properties, the effect was confounded by other MgSt properties. The C16/C18 ratio also had minimal effect on tablet physical properties. The results further showed that although MgSt with smaller particle size, higher crystallinity and moisture content provided better flowability, the resultant tablets had lower tensile strength. These findings highlighted the importance of MgSt properties for formulations of good flowability and tablet physical properties.
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Kaniuk, Natalia A.,Canadien, Veronica,Bagshaw, Richard D.,Bakowski, Malina,Braun, Virginie,Landekic, Marija,Mitra, Shuvadeep,Huang, Ju,Heo, Won Do,Meyer, Tobias,Pelletier, Laurence,Andrews‐,Poly Blackwell Publishing Ltd 2011 Cellular microbiology Vol.13 No.11
<P><B>Summary</B></P><P>The facultative intracellular pathogen <I>Salmonella enterica</I> serovar Typhimurium establishes a replicative niche, the <I>Salmonella</I>‐containing vacuole (SCV), in host cells. Here we demonstrate that these bacteria exploit the function of Arl8B, an Arf family GTPase, during infection. Following infection, Arl8B localized to SCVs and to tubulated endosomes that extended along microtubules in the host cell cytoplasm. Arl8B<SUP>+</SUP> tubules partially colocalized with LAMP1 and SCAMP3. Formation of LAMP1<SUP>+</SUP> tubules (the <I>Salmonella</I>‐induced filaments phenotype; SIFs) required Arl8B expression. SIFs formation is known to require the activity of kinesin‐1. Here we find that Arl8B is required for kinesin‐1 recruitment to SCVs. We have previously shown that SCVs undergo centrifugal movement to the cell periphery at 24 h post infection and undergo cell‐to‐cell transfer to infect neighbouring cells, and that both phenotypes require kinesin‐1 activity. Here we demonstrate that Arl8B is required for migration of the SCV to the cell periphery 24 h after infection and for cell‐to‐cell transfer of bacteria to neighbouring cells. These results reveal a novel host factor co‐opted by <I>S</I>. Typhimurium to manipulate the host endocytic pathway and to promote the spread of infection within a host.</P>
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