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Gonzalez-Herrera, A.L.,Salgado-Bernabe, M.,Velazquez-Velazquez, C.K.,Salcedo-Vargas, M.,Andrade-Manzano, A.,Avila-Moreno, F.,Pina-Sanchez, P. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Background: Cervical cancer (CeCa) is the second most common cancer in women in developing countries, and human papilloma virus (HPV) is the primary etiological factor. Aberrant expression of HOX transcription factors has been observed in several types of cancer. To date, however, no reports exist on the expression of HOXB2 and HOXB13 proteins during neoplastic progression in CeCa and its correlation with HPV infection. Materials and Methods: Expression of HOXB2 and HOXB13 proteins was assessed in tissue microarrays from normal cervical epithelium, cervical intraepithelial neoplasias grade 1-3, and CeCa. HPV was detected by PCR and sequencing. Expression of HOX-positive cells was determined in each diagnostic group. Results: Percentage of HOXB2- and HOXB13-positive cells gradually increased from means of 10.9% and 16.7%, respectively, in samples from healthy women, to 75.2% and 88.6% in those from CeCa patients. Frequency of HPV infection also increased from 13% in healthy tissue samples to 92.3% in CeCa. Both HOXB2 and HOXB13 proteins were preferentially expressed in HPV+ samples. Conclusions: The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.
Vera-Cabrera, Lucio,Gonzalez, Eva,Rendon, Adrian,Ocampo-Candiani, Jorge,Welsh, Oliverio,Velazquez-Moreno, Victor M.,Hak Choi, Sung,Molina-Torres, Carmen American Society for Microbiology 2006 Antimicrobial agents and chemotherapy Vol.50 No.9
<B>ABSTRACT</B><P>The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of <I>Nocardia brasiliensis</I> and <I>Mycobacterium tuberculosis</I> were determined. Equal MIC50s and MIC90s (0.25 and 0.5 μg/ml, respectively) were found for susceptible and multidrug-resistant isolates of <I>M. tuberculosis</I>. The <I>N. brasiliensis</I> isolates showed an MIC90 of 1 μg/ml and an MIC50 of 1 μg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for <I>M. tuberculosis</I> but fivefold-higher MICs for <I>N. brasiliensis</I>.</P>
Zn-22Al-2Cu Alloy Phase Transformations at Different Homogenizing Temperatures
Héctor Javier Dorantes-Rosales,Víctor Manuel López-Hirata,Ramón Esquivel-González,Jorge Luis González-Velazquez,Joel Moreno-Palmerin,Antonio Torres-Castillo 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.3
The effect of the homogenizing temperature on phase transformations and hardening behavior was studied in a Zn-22Al-2Cu (wt%) alloy homogenized for 7 days at 315, 350, and 390°C. The homogenized alloy was subsequently quenched and aged naturally at room temperature or artificially at 200°C for different time periods. The β phase was unstable at room temperature and it decomposed through the β→α+ηreaction during natural aging. An increase in the homogenizing temperature caused a decrease in the kinet-ics of the decomposition of the β phase in the alloy. Natural aging also caused an increase in the hardness due to the formation of nanometric grains with α and η phases and the presence of an intermetallic εphase. This result agrees with the time exponents (n) between 1.5 and 2.6, which were obtained using the Johnson-Mehl-Avrami-Kolmogorov equation for the decomposition of the β phase. The transformed frac-tion curves exhibited the fastest and slowest growth kinetics of the â phase decomposition at homogeniz-ing temperatures of 350 and 390°C, respectively. The artificial aging induced the formation of equilibrium phases and began a decrease in hardness due to the coarsening process of the equilibrium α, η, and τ'phases.