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- 저자 : Uren, Mehmet Cemil (검색결과 4 건)
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Definition and symptoms of underactive bladder
Alan D. Uren,Marcus J. Drake 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.-
Underactive bladder (UAB) is a symptom syndrome reflecting the urodynamic observation of detrusor underactivity (DU), a voiding contraction of reduced strength and/or duration, leading to prolonged or incomplete bladder emptying. An International Continence Society Working Group has described UAB as characterised by a slow urinary stream, hesitancy and straining to void, with or without a feeling of incomplete bladder emptying and dribbling, often with storage symptoms. Since DU often coexists with bladder outlet obstruction, or storage dysfunction (detrusor overactivity or incontinence), the exact contribution of the DU to the presenting complaints can be difficult to establish. The presence of voiding and post voiding lower urinary tract symptoms (LUTS) is implicitly expected in UAB, but a reduced sensation of fullness is reported by some patients, and storage LUTS are also an important factor in many affected patients. These may result from a postvoid residual, but often they do not. The storage LUTS are often the key driver in leading the patient to seek healthcare input. Nocturia is particularly common and bothersome, but what the role of DU is in all the range of influences on nocturia has not been established. Qualitative research has established a broad impact on everyday life as a result of these symptoms. In general, people appear to manage the voiding LUTS relatively well, but the storage LUTS may be problematic.
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Phenolic composition, enzyme inhibitory, and antioxidant activity of Bituminaria bituminosa
Sarikurkcu, Cengiz,Cengiz, Mustafa,Uren, Mehmet Cemil,Ceylan, Olcay,Orenc, Tuba,Tepe, Bektas 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.5
This study aimed to evaluate the in vitro antioxidant and enzyme inhibitory activities of ethyl acetate, methanol, and water extracts of Bituminaria bituminosa. In phosphomolybdenum assay, the methanol extract showed the highest activity ($166.78{\mu}mol\;TEs/g$ dry plant). The water extract exhibited the highest scavenging activity on 1,1-diphenyl-2-picrylhydrazyl ($DPPH^{\bullet}$) and 2,2-azino-bis (3-ethylbenzothiazloine-6-sulphonic acid) ($ABTS^{{\bullet}+}$). In addition, it exhibited the highest activity in cupric ion reducing (CUPRAC) and ferric reducing antioxidant power (FRAP) assays (41.26 and $46.82{\mu}mol\;TEs/g$ dry plant). The extracts did not show cholinesterase and tyrosinase inhibitory activity. However, ${\alpha}$-glucosidase inhibition assay resulted in the superiority of water extract ($1233.86{\mu}mol\;ACEs/g$ dry plant). In the case of ${\alpha}$-amylase inhibitory assay, the ethyl acetate extract showed the highest activity ($53.65{\mu}mol\;ACEs/g$ dry plant). The water extract exhibited the highest phenolic content ($31.70{\mu}mol\;GAEs/g$ dry plant). In contrast, the methanol extract was found rich in flavonoid compounds ($5.29{\mu}mol\;REs/g$ dry plant). The water extract contained considerable amounts of rosmarinic acid, luteolin, quercetin, and rutin. Therefore, it can be used as a source of new and alternative antioxidant and enzyme inhibitory agents.
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Cengiz Sarikurkcu,Mehmet Cemil Uren,Mehmet Sefa Kocak,Mustafa Cengiz,Bektas Tepe 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.3
This study aimed to investigate the chemical composition, antioxidant, and enzyme inhibitory activities of the essential oils of Phlomis armeniaca WILLD., P. nissolii L., and P. pungens WILLD. var. pungens as well as their fatty acid contents. Germacrene D was found as the major compound in the oils (24.7, 15.1, and 7.2%, respectively). Additionally, n-hexadecanoic acid, hexahydrofarnesyl acetone, β-caryophyllene, and linalool were the other main compounds in the oils. Among the fatty acids, C18:3 ω3 and C18:2 ω6 were determined in high quantities in P. armeniaca (23.14 and 18.01%, respectively) and P. pungens var. pungens (24.64 and 17.51%, respectively). The essential oils of P. armeniaca and P. pungens var. pungens showed remarkable antioxidant and metal chelating activities as well as great reducing power potentials. These oils also showed a moderate scavenging effect on ABTS radicals. The oils also exhibited various degrees of inhibitory activities on AChE, BChE, α-amylase, α-glucosidase, and tyrosinase.
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Phenolic composition, enzyme inhibitory, and antioxidant activity of Bituminaria bituminosa
Cengiz Sarikurkcu,Mustafa Cengiz,Mehmet Cemil Uren,Olcay Ceylan,Tuba Orenc,Bektas Tepe 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.5
This study aimed to evaluate the in vitro antioxidant and enzyme inhibitory activities of ethyl acetate, methanol, and water extracts of Bituminaria bituminosa. In phosphomolybdenum assay, the methanol extract showed the highest activity (166.78 μmol TEs/g dry plant). The water extract exhibited the highest scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH•) and 2,2-azino-bis (3- ethylbenzothiazloine-6-sulphonic acid) (ABTS•+). In addition, it exhibited the highest activity in cupric ion reducing (CUPRAC) and ferric reducing antioxidant power (FRAP) assays (41.26 and 46.82 μmol TEs/g dry plant). The extracts did not show cholinesterase and tyrosinase inhibitory activity. However, α-glucosidase inhibition assay resulted in the superiority of water extract (1233.86 μmol ACEs/g dry plant). In the case of α-amylase inhibitory assay, the ethyl acetate extract showed the highest activity (53.65 μmol ACEs/g dry plant). The water extract exhibited the highest phenolic content (31.70 μmol GAEs/g dry plant). In contrast, the methanol extract was found rich in flavonoid compounds (5.29 μmol REs/g dry plant). The water extract contained considerable amounts of rosmarinic acid, luteolin, quercetin, and rutin. Therefore, it can be used as a source of new and alternative antioxidant and enzyme inhibitory agents.
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