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RISS 인기검색어
- 검색키워드
- 저자 : Tzu-Hsuan Ho (검색결과 2 건)
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Supervised Control for Robot-Assisted Surgery Using Augmented Reality
Tzu-Hsuan Ho,Kai-Tai Song 제어로봇시스템학회 2020 제어로봇시스템학회 국제학술대회 논문집 Vol.2020 No.10
In this paper, we propose an AR-based robotic system that can plan and execute a trajectory based on a 3D medical model and allow the surgeon to supervise the execution of surgical process. In order to achieve image-guided surgery, a hand-eye calibration procedure is developed by using AprilTag to obtain the transformation between the workspace coordinate and the robot coordinate, and perform the image navigation task of the surgical robot to complete a drilling task. A procedure of robot supervised control is proposed to assign or modify the robot trajectory based on AR visualization and 3D model. A specified AR marker is used to project virtual objects in the AR glasses. We developed a robot registration algorithm to match the AR virtual coordinate system and the workspace coordinate system, and convert the planned trajectory into robot trajectory. Experimental results on the lab-built robotic system show that a user can adjust the position and orientation of the insertion point on a bone model, and transmit the trajectory information to the robot for execution. The proposed visualization-based robot navigation method has the potential to enhance the safety of surgical operation.
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Angelica dahurica attenuates melanogenesis in B16F0 cells by repressing Wnt/β-catenin signaling
Fang Chien-Liang,Goswami Debakshee,Kuo Chia-Hua,Day Cecilia Hsuan,Lin Mei-Yi,Ho Tsung-Jung,Yang Liang-Yo,Hsieh Dennis Jine-Yuan,Lin Tzu-Kai,Huang Chih-Yang 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1
Background Melanogenesis is a complex process which is tightly regulated by several enzymes. However, abnormal melanogenesis can cause severe dermatological problems. Roots of Angelica dahurica have been used for skin care as a part of traditional Chinese medicine for many generations. However, the role of A. dahurica in melanogenesis remains unclear. Objective Previous in vitro and in vivo studies have demonstrated that NK-1R exerts positive effects in melanogenesis via the Wnt/βcatenin signaling pathway. In this study, we investigated the effects of A. dahurica ethanol extract (ADE) on NK-1R and Wnt/β-catenin signaling, and evaluated the effect of NK-1R on melanogenesis in B16F0 cells. Results Angelica dahurica ethanol extract efficiently downregulated Neurokinin-1 receptor and Wnt/β-catenin signaling by decreasing the expression of β-catenin, MITF, LEF-1, TYR, TRP1, and TRP2 and increasing the expression of GSK3β, which resulted from the weakened expression of the Neurokinin-1 receptor inhibitor [Sar9,Met(O2 )11]-Substance P (SMSP). Furthermore, the intracellular melanin assay and cellular tyrosinase activity confirmed these findings. Conclusion This study suggests that ADE has potential to downregulate Neurokinin-1 receptor in SMSP-induced B16F0 cells, thereby repressing the Wnt/β-catenin signaling and reduces melanin production.
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