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Truman, Andrew W.,Kwun, Min Jung,Cheng, Jinhua,Yang, Seung Hwan,Suh, Joo-Won,Hong, Hee-Jeon American Society for Microbiology 2014 Antimicrobial Agents and Chemotherapy Vol.58 No.10
<P>Discovering new antibiotics is a major scientific challenge, made increasingly urgent by the continued development of resistance in bacterial pathogens. A fundamental understanding of the mechanisms of bacterial antibiotic resistance will be vital for the future discovery or design of new, more effective antibiotics. We have exploited our intimate knowledge of the molecular mechanism of glycopeptide antibiotic resistance in the harmless bacterium <I>Streptomyces coelicolor</I> to develop a new two-step cell wall bioactivity screen, which efficiently identified a new actinomycete strain containing a previously uncharacterized glycopeptide biosynthetic gene cluster. The screen first identifies natural product extracts capable of triggering a generalized cell wall stress response and then specifically selects for glycopeptide antibacterials by assaying for the induction of glycopeptide resistance genes. In this study, we established a diverse natural product extract library from actinomycete strains isolated from locations with widely varying climates and ecologies, and we screened them using the novel two-step bioassay system. The bioassay ultimately identified a single strain harboring the previously unidentified biosynthetic gene cluster for the glycopeptide ristocetin, providing a proof of principle for the effectiveness of the screen. This is the first report of the ristocetin biosynthetic gene cluster, which is predicted to include some interesting and previously uncharacterized enzymes. By focusing on screening libraries of microbial extracts, this strategy provides the certainty that identified producer strains are competent for growth and biosynthesis of the detected glycopeptide under laboratory conditions.</P>
STOCHASTIC MEHLER KERNELS VIA OSCILLATORY PATH INTEGRALS
Truman, Aubrey,Zastawniak, Tomasz Korean Mathematical Society 2001 대한수학회지 Vol.38 No.2
The configuration space and phase space oscillatory path integrals are computed in the case of the stochastic Schrodinger equation for the harmonic oscillator with a stochastic term of the form (K$\psi$(sub)t)(x) o dW(sub)t, where K is either the position operator or the momentum operator, and W(sub)t is the Wiener process. In this way formulae are derived for the stochastic analogues of the Mehler kernel.
MouthNode: Exploring Actuation in the Mouth to Convey Information
Edwin Truman,Seungwoo Je,Andrea Bianchi 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
Through haptic feedback, information can be directly transferred to the user in private. So, there are previous researches conducted on various parts of the body as a medium of information transfer such as the ear, finger, and wrist. However, the teeth, which is as sensitive as finger or ear has not been explored. In this paper, we propose MouthNode, which uses an unshielded Linear Resonant Actuator (LRA) system to convey information on the teeth through vibration. From the technical evaluation, our prototype can generate up to 0.28N of force, and through our pilot study, the user can feel a stimulus at a minimum force of 0.23N. This result confirms that this system is feasible in conveying information through tactile feedback on the teeth.
Woo, W.,An, G. B.,Truman, C. E.,Jiang, W.,Hill, M. R. Springer Science + Business Media 2016 JOURNAL OF MATERIALS SCIENCE - Vol.51 No.23
<P>Residual stress variations were determined through the thickness of a 70-mm-thick ferritic-austenitic dissimilar steel weld using contour method, deep hole drilling, and neutron diffraction. The result shows that significant tensile stresses were distributed distinctly along the interface between ferritic and austenitic phases. The band of the large tensile stresses was about 8 mm wide and the magnitude reached 400 MPa, which is approaching 100 % of the yield strength of the base metal, near the top surface (about 15 % of the depth). It is attributed to the large difference (5.8 x 10(-6) 1/A degrees C) of the thermal expansion coefficient between ferritic and austenitic steels of the interface. The microstructure analysis elucidates that the martensitic phase prevailed near the interface and results in microhardness increases.</P>
Danah Harbour,Ella Henson,Chelsea Boers,Darcy Truman,Chandima Fernando,Patrick J. Guay,Michael A. Weston 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1
Escape behaviour is a critical component of invertebrate life history but is poorly studied. Flight initiation distance (FID) indexes escape propensity, and is wellstudied in vertebrates but is entirely unstudied in Lepidopterans, despite their obvious escape behaviour. Here we test two general principles regarding FID as derived from studies of vertebrates to examine if they apply to Sri Lankan butterflies: 1) that FID is a species-specific trait and 2) that FID increases with Starting Distance, the distance at which the experimenter begins an approach. We collected 295 FIDs from 17 species and find that 1) FIDs are a tractable way of indexing butterfly escape and 2) both the general principles tested apply to butterfly escape. We also present FIDs of these species to encourage further data collection and comparative analysis of butterfly escape.