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RISS 인기검색어
- 검색키워드
- 저자 : Tomoyuki Matsunaga (검색결과 4 건)
- 무료
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Gastric Adenocarcinoma with Thymic Metastasis after Curative Resection: A Case Report
Matsunaga, Tomoyuki,Saito, Hiroaki,Miyatani, Kozo,Takaya, Seigo,Fukumoto, Yoji,Osaki, Tomohiro,Ikeguchi, Masahide The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.3
The peritoneum is the most frequent site of recurrence for gastric cancer after gastrectomy, followed by the liver and lymph nodes. In contrast, metastasis to the thymus is rare. Annual surveillance with computed tomography was performed on a 67-year-old man who previously underwent a distal gastrectomy and D2 lymph node dissection for gastric cancer at Tottori University. Five years after the initial operation, an anterior mediastinal tumor was detected by computed tomography. The patient underwent video-assisted thoracic surgery to remove the tumor. Histopathology revealed adenocarcinoma cells similar to those of the gastric cancer resected 5 years previously. Thymic metastasis was considered likely based on the location of the tumor. The recognition that gastric cancer can metastasize to unusual anatomic locations, such as the thymus, can facilitate an accurate, prompt diagnosis and appropriate treatment.
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Gastric Adenocarcinoma with Thymic Metastasis after Curative Resection: A Case Report
Tomoyuki Matsunaga,Hiroaki Saito,Kozo Miyatani,Seigo Takaya,Yoji Fukumoto,Tomohiro Osaki,Masahide Ikeguchi 대한위암학회 2014 Journal of gastric cancer Vol.14 No.3
The peritoneum is the most frequent site of recurrence for gastric cancer after gastrectomy, followed by the liver and lymph nodes. Incontrast, metastasis to the thymus is rare. Annual surveillance with computed tomography was performed on a 67-year-old man whopreviously underwent a distal gastrectomy and D2 lymph node dissection for gastric cancer at Tottori University. Five years after theinitial operation, an anterior mediastinal tumor was detected by computed tomography. The patient underwent video-assisted thoracicsurgery to remove the tumor. Histopathology revealed adenocarcinoma cells similar to those of the gastric cancer resected 5 years previously. Thymic metastasis was considered likely based on the location of the tumor. The recognition that gastric cancer can metastasizeto unusual anatomic locations, such as the thymus, can facilitate an accurate, prompt diagnosis and appropriate treatment.
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Electrodeposition of an alumina precursor on a silicon carbide surface
Yoshihiro Hirata,Masaru Murao,Tomoyuki Maeda,Naoki Matsunaga,Soichiro Sameshima 한양대학교 세라믹연구소 2007 Journal of Ceramic Processing Research Vol.8 No.5
An electrodeposition method was used to form nanometre-sized alumina particles on a silicon carbide surface. A direct current in the range from 0.15 to 11.8 mA/m2 was flowed between a cylindrical carbon cathode and a porous silicon carbide anode in an aqueous solution containing ethylenediaminetetraacetatoaluminium (III) (Al-EDTA¯) at a pH 6. The current density increased with an increase of the applied voltage and showed a maximum as a function of deposition time. The deposited alumina precursor was estimated to be (OH)Al(OOCH)2. After calcination at 800ºC in an Ar atmosphere, the uniformly deposited precursor changed to alumina particles with a specific surface area of 44.3 m2/g. An electrodeposition method was used to form nanometre-sized alumina particles on a silicon carbide surface. A direct current in the range from 0.15 to 11.8 mA/m2 was flowed between a cylindrical carbon cathode and a porous silicon carbide anode in an aqueous solution containing ethylenediaminetetraacetatoaluminium (III) (Al-EDTA¯) at a pH 6. The current density increased with an increase of the applied voltage and showed a maximum as a function of deposition time. The deposited alumina precursor was estimated to be (OH)Al(OOCH)2. After calcination at 800ºC in an Ar atmosphere, the uniformly deposited precursor changed to alumina particles with a specific surface area of 44.3 m2/g.
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Lee Seon Hwa,Tsutsui Mizuki,Matsunaga Atsushi,Oe Tomoyuki 한국독성학회 2023 Toxicological Research Vol.39 No.1
Oxidative stress is strongly associated with the onset and/or progression of diabetes. Under conditions of oxidative stress, lipid hydroperoxides are decomposed to reactive aldehydes that have been reported to induce insulin resistance by modifying proteins involved in insulin signaling. Pyridoxamine (PM) can inhibit the formation of advanced glycation/lipoxidation end products by scavenging reactive carbonyl species. Thus, PM has emerged as a promising drug candidate for various chronic conditions, including diabetic complications. In this study, L6 skeletal muscle cells were treated with 4-oxo-2(E)- nonenal (ONE), one of the most abundant and reactive lipid-derived aldehydes. Cellular insulin resistance was assessed by measuring insulin-stimulated glucose uptake using 2-deoxyglucose. ONE induced a time- and dose-dependent decrease in glucose uptake. Liquid chromatography/electrospray ionization-mass spectrometry analysis of the reaction between ONE and insulin receptor substrate 1 (IRS1) lysate identified multiple modifications that could disturb the interaction between IRS1 and activated IR, leading to insulin resistance. Pretreatment of the cells with PM restored the ONE-induced decrease in glucose uptake. Concomitantly, the formation of PM-ONE adducts in cell culture medium was increased in a PM-dose dependent manner. PM can therefore prevent lipid hydroperoxide-derived insulin resistance by quenching ONE.
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