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Intelligent Shimming for Deep Drawing Processes
Søren Tommerup,Benny Endelt,Joachim Danckert,Karl Brian Nielsen 한국소성가공학회 2011 기타자료 Vol.2011 No.8
This paper demonstrates the use of an intelligent shimming system to compensate for changes in process output due to tool wear. A new tool concept with integrated hydraulic cavities used as actuators in feedback control system is presented. By prescribing a hydraulic pressure in the individual cavities the blank-holder force distribution can be controlled during the punch stroke. By means of a sequence of numerical simulations abrasive wear is imposed to the deep drawing of a rectangular cup. The abrasive wear is modelled by changing the tool surface geometry using an algorithm based on the sliding energy density. As the tool surfaces are changed the material draw-in is significantly altered when using conventional open-loop control of the blank-holder force. A feed-back controller is presented which is capable of reducing the draw-in difference to a certain degree. Further a learning algorithm is introduced to the system, which is able to improve the response of the feed-back system significantly.
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Ambrin Fatima,Muhammad Farooq,Uzma Abdullah,Muhammad Tariq,Tanveer Mustafa,Muhammad Iqbal,Niels Tommerup,Shahid Mahmood Baig 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.5
Objective: Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. Recently, MIR137, CACNA1C, CSMD1, DRD2, and GRM3 have been reported as the most robustly emerging candidates involved in the etiology of schizophrenia. In this case control study, we performed an association analysis of rs1625579 (MIR137), rs1006737, rs4765905 (CACNA1C), rs10503253 (CSMD1), rs1076560 (DRD2), rs12704290, rs6465084, and rs148754219 (GRM3) in Pakistani population. Methods: Schizophrenia was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV). Detailed clinical information, family history of all patients and healthy controls were collected. RFLP based case control association study was performed in a Pakistani cohort of 508 schizophrenia patients and 300 healthy control subjects. Alleles and genotype frequencies were calculated using SPSS. Results: A significant difference in the genotype and allele frequencies for rs4765905, rs1076560 and rs6465084 were found between the patients and controls (p=0.000). Conclusion: This study provides substantial evidence supporting the role of CACNA1C, GRM3 and DRD2 as schizophrenia susceptibility genes in Pakistani population.
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Linda P. Jakobsen,Rehannah Borup,Janni Vestergaard,Lars A. Larsen,Kasper Lage,Lisa Leth Maroun,Inger Kjaer,Carsten U. Niemann,Mikael Andersen,Mary A. Knudsen,Kjeld Møllgård,Niels Tommerup 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.2
Cleft lip and/or palate (CL/P) is a common congenital malformation with a complex etiology which is not fully elucidated yet. Epidemiological studies point to different etiologies in the cleft lip and palate subgroups, isolated cleft lip (CL), isolated cleft palate (CP) and combined cleft lip and palate (CLP). In order to understand the biological basis in these cleft lip and palate subgroups better we studied the expression profiles in human tissue from patients with CL/P. In each of the CL/P subgroups, samples were obtained from three patients and gene expression analysis was performed. Moreover, selected differentially expressed genes were analyzed by quantitative RT-PCR, and by immunohistochemical staining of craniofacial tissue from human embryos. Osteopontin (SPP1) and other immune related genes were significantly higher expressed in palate tissue from patients with CLP compared to CP and immunostaining in palatal shelves against SPP1, chemokine receptor 4 (CXCR4) and serglycin (PRG1) in human embryonic craniofacial tissue were positive, supporting a role for these genes in palatal development. However, gene expression profiles are subject to variations during growth and therefore we recommend that future gene expression in CL/P studies should use tissue from the correct embryonic time and place if possible, to overcome the biases in the presented study. Cleft lip and/or palate (CL/P) is a common congenital malformation with a complex etiology which is not fully elucidated yet. Epidemiological studies point to different etiologies in the cleft lip and palate subgroups, isolated cleft lip (CL), isolated cleft palate (CP) and combined cleft lip and palate (CLP). In order to understand the biological basis in these cleft lip and palate subgroups better we studied the expression profiles in human tissue from patients with CL/P. In each of the CL/P subgroups, samples were obtained from three patients and gene expression analysis was performed. Moreover, selected differentially expressed genes were analyzed by quantitative RT-PCR, and by immunohistochemical staining of craniofacial tissue from human embryos. Osteopontin (SPP1) and other immune related genes were significantly higher expressed in palate tissue from patients with CLP compared to CP and immunostaining in palatal shelves against SPP1, chemokine receptor 4 (CXCR4) and serglycin (PRG1) in human embryonic craniofacial tissue were positive, supporting a role for these genes in palatal development. However, gene expression profiles are subject to variations during growth and therefore we recommend that future gene expression in CL/P studies should use tissue from the correct embryonic time and place if possible, to overcome the biases in the presented study.
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