http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy
Tomás Lopes da Fonseca,Tiago Fleming Outeiro 한국뇌신경과학회 2014 Experimental Neurobiology Vol.23 No.4
Parkinson’s Disease (PD) is a complex and multifactorial disorder of both idiopathic and genetic origin. Thus far, more than 20 geneshave been linked to familial forms of PD. Two of these genes encode for ATP13A2 and alpha-synuclein (asyn), proteins that seemto be members of a common network in both physiological and disease conditions. Thus, two different hypotheses have emergedsupporting a role of ATP13A2 and asyn in metal homeostasis or in autophagy. Interestingly, an appealing theory might combinethese two cellular pathways. Here we review the novel findings in the interaction between these two proteins and debate the excitingroads still ahead.