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Hima Bindu Ruttala,Thiruganesh Ramasamy,Thiagarajan Madeshwaran,Tran Tuan Hiep,Umadevi Kandasamy,오경택,최한곤,용철순,김종오 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.2
The development of novel drug delivery systemsbased on well-defined polymer therapeutics has led tosignificant improvements in the treatment of multiple disorders. Advances in material chemistry, nanotechnology,and nanomedicine have revolutionized the practices ofdrug delivery. Stimulus-responsive material-based nanosizeddrug delivery systems have remarkable propertiesthat allow them to circumvent biological barriers andachieve targeted intracellular drug delivery. Specifically,the development of novel nanocarrier-based therapeutics isthe need of the hour in managing complex diseases. In thisreview, we have briefly described the fundamentals of drugtargeting to diseased tissues, physiological barriers in thehuman body, and the mechanisms/modes of drug-loadedcarrier systems. To that end, this review serves as acomprehensive overview of the recent developments instimulus-responsive drug delivery systems, with focus ontheir potential applications and impact on the future of drugdelivery.