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RISS 인기검색어
- 검색키워드
- 저자 : Thawatchai Phaechamud (검색결과 5 건)
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Design, fabrication and characterization of xanthan gum/liquidloaded porous natural rubber film
Thawatchai Phaechamud,Nutdanai Lertsuphotvanit,Pongsathorn Issarayungyuen,Takron Chantadee 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.1
Porous natural rubber (NR) films were prepared with blocked natural rubber by solvent casting method using dichloromethane as the solvent. The various amount of xanthan gum (0–40 phr) was blended in 75 phr triethyl citrate or glycerin-loaded NR cast films. Xanthan gum markedly promoted the water sorption of these composite films. The proper compatibility of the component employed in these composite NR films was confirmed by X-ray diffractometry, thermogravimetry and differential scanning calorimetry. Although the porosity of composite NR films decreased when xanthan gum was added xanthan gum amount did not significantly affect the mechanical properties, wettability and degradability. The 20 phr xanthan gum was selected as the optimum amount to modify the liquid-loaded NR films for further as wound dressing.
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Thawatchai Phaechamud,Jongjan Mahadlek,Sarun Tuntarawongsa 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.4
Antibiotic-loaded in situ forming gels are particularly attractive for periodontitis treatment. They are in a sol form and gradually alter to a solid-like depot after administration into a periodontal pocket to deliver and maintain the effective high level of drug in the gingival crevicular fluid. Solvent-inducing in situ forming gel mostly exhibits the burst drug release owing to rapid diffusion of solvent. This study incorporated peppermint oil to modulate the drug release and the gel characteristics of doxycycline hyclate-loaded Eudragit RS in situ forming gel systems. Peppermint oil increased the viscosity and syringeability of the Eudragit RS solution comprising NMP as solvent and retarded the water penetration. Therefore the diminishment of burst liberation and the prolongation of drug release with an addition of peppermint oil were attained with concentration dependence mainly following Fickian diffusion mechanism. The drug release from the membrane-less diffusion method was apparently slower than that from the dialysis method because the rapid phase separation into solid-like matrix through a direct contact with dissolution medium generated a hard surrounding shell. These solvent exchange-inducing in situ forming gels comprising peppermint oil effectively inhibited Staphylococcus aureus, Escherichia coli, Streptococcus mutans and Porphyrommonas gingivalis; therefore, they exhibited the potential use as localized delivery systems for periodontitis treatment.
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Thawatchai Phaechamud,Pitsiree Praphanwittaya,Kunchalee Laotaweesub 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3
This research purposed to better comprehend the behavior of solvent including dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP) and 2-pyrrolidone (PYR) in bleached shellac solution from preparation process of in situ forming gel (isg) and microparticle (ism). Doxycycline hyclate-loaded bleached shellac isg was used as the internal phase of oil in oil emulsion of ism. Fluid characteristics including pH, density, relative viscosity and surface/interfacial tension, droplet size of emulsion, phase separation rate and apparent viscosity were determined. Bleached shellac dissolved in these solvents via strongly hydrogen bonding and van der Wall forces. In the case of ism systems, the trend of viscosity was similar with isg but their viscosity was lower because of the presence of oil in the external phase. PYR formula were the most viscous whereas those prepared with NMP were contrary therefore PYR could interact with bleached shellac molecule less than NMP. The solubility parameter, interfacial tension, apparent and relative viscosities confirmed that NMP was a good solvent for this resin. However, NMP exhibited a partial miscible with oil; thus, generated a rapid phase separation. Therefore DMSO and PYR could use as the solvents to fabricate into the o/o emulsion of ism with a suitable manner for local injection owing to their newtonian or pseudoplastic flows. These results will be useful for future investigation of physicochemical characteristics of obtained gel or microparticle and also their solvent exchange and drug release behavior.
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Prachya Katewongsa,Prachya Katewongsa,Thawatchai Phaechamud 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.3
Recently, the fast disintegrating tablet (FDT) has started gaining popularity and acceptance as a new drug delivery system. Lubricants could influence on disintegration time (DT), hardness, wetting time (WT) and dissolution of FDT. This study investigated the effects of amount and type of lubricants (magnesium stearate and sodium stearyl fumarate) as well as compression force on characteristics of the cetirizine dihydrochloride (CD) FDT. The spatial distribution of lubricants in tablets had been analyzed using Raman mapping and scanning electron microscopy–energy dispersive X-ray spectroscopy. The more concentration of lubricants or higher compression force resulted in more distribution of lubricant therefore hindering water penetration into the tablet. In addition, CD FDT was prepared by direct compression method. A 32 full factorial design was applied for the optimization of CD FDT. By adopting a systematic formulation approach, the closeness between predicted and observed values (DT, WT, contact angle, surface free energy, hardness) indicated the validity of derived equations for the dependent variables. Sodium stearyl fumarate had less impact on hardness and disintegration time than magnesium stearate. Therefore, FDT containing sodium stearyl fumarate as lubricant showed higher drug release than that containing magnesium stearate.
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Wai Wai Lwin,Napaphol Puyathorn,Setthapong Senarat,Jongjan Mahadlek,Thawatchai Phaechamud 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.1
Phase separation with solvent exchange induced-in situ forming gel (ISG) is an attractive delivery system for periodontitis treatment. Eudragit ® RS-PO (ERS) in N-methyl pyrrolidone (NMP) was used as polymer matrix for doxycycline hyclate (DH)-loaded solvent-exchanged ISG; however, a high burst drug release was evident. The present study revealed the role of PEG 1500 on physicochemical properties and modification of a burst release for DH-loaded ISG. DH-loaded ISG system comprising PEG 1500 exhibited the Newtonian flow with acceptable injectability with PEG 1500 concentration dependence and high in vitro degradation owing to NMP and PEG 1500 liberation. Solvent exchange between NMP with PBS pH 6.8 conveyed the rapid phase separation of ERS/PEG 1500 as a matrix which the entrapped DH diffused out gradually. Both dialysis membrane and membrane-less methods proved the slower drug release of DH-loaded ERS ISG comprising PEG than PEG 1500-free ISG. SEM revealed the porous matrix topography from polymeric phase separation especially for higher PEG 1500 loading. PEG 1500 incorporation significantly decreased the inhibition diameter against S. aureus, E. coli and S. mutans (P < 0.05) indicating the retardation of drug release owing to the high viscosity of the PEG 1500. PEG 1500-incorporated DH-loaded ERS ISG exhibited the potential use for periodontitis treatment.
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