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Nakaoka, Yoshikazu,Nishida, Keigo,Narimatsu, Masahiro,Kamiya, Atsunori,Minami, Takashi,Sawa, Hirofumi,Okawa, Katsuya,Fujio, Yasushi,Koyama, Tatsuya,Maeda, Makiko,Sone, Manami,Yamasaki, Satoru,Arai, Yu American Society for Clinical Investigation 2007 The Journal of clinical investigation Vol.117 No.7
Effect of denosumab on renal function in women with osteoporosis evaluated using cystatin C
Tsuyoshi Ohishi,Tomotada Fujita,Tatsuya Nishida,Kazuhiro Hagiwara,Reina Murai,Yukihiro Matsuyama 대한골다공증학회 2022 Osteoporosis and Sarcopenia Vol.8 No.2
Objectives: To investigate renal function during denosumab therapy using the estimated glomerular filtration rate based on cystatin C (eGFRcys) which is more accurate than creatinine (eGFRcr) for renal function. Methods: Bone mineral densities (BMDs) of lumbar spine and hip regions, eGFRcys, eGFRcr, creatinine clearance (Ccr), and serum total homocysteine (S-Hcy) were measured during 2-year denosumab therapy in 53 women with osteoporosis naïve to anti-osteoporosis drugs (new group) and 64 women who were switched from long-term bisphosphonate treatment to denosumab therapy (switch group). Results: There were no significant differences in age, eGFRcr, Ccr, eGFRcys, and S-Hcy levels at baseline between the groups. BMDs in the lumbar spine, femoral neck, and total hip increased significantly after 2-year denosumab therapy in both groups. eGFRcr decreased in the switch group, and Ccr decreased in both groups; however, eGFRcys and S-Hcy levels did not change significantly in either group. To investigate the causal factors associated with the decrease in eGFRcr and Ccr, multiple regression analysis was performed in all patients. Denosumab initiation within 3 months after fracture and eGFRcr or Ccr at baseline were independent factors for the decrease in eGFRcr or Ccr during the 2-year denosumab therapy. Decline in creatinine-based renal function could be reflected by increased muscle mass during the ongoing recovery from fracture. Conclusions: Renal function was preserved in all patients, including those in the switch group during denosumab therapy. Creatinine-based renal function should be cautiously interpreted during denosumab therapy in patients with recent fractures.
( Shintaro Uchitomi ),( Hongliang Luo ),( Keiya Nishida ),( Youichi Ogata ),( Wu Zhang ),( Tatsuya Fujikawa ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-
The recent strict regulation of emission for internal combustion engines requires the reduction of pollutant emissions such as soot. The direct-injection spark-ignition (DISI) engine, which has been widely used for passenger cars, can improve thermal efficiency and reduce the emission of carbon dioxide. However, as fuel is injected directly into the cylinder, it is difficult to avoid the wall impingement of spray on the combustion chamber. And liquid films inevitably form on the piston and cylinder surfaces. These films are possible sources of unburnt hydrocarbons and soot emissions. In addition, liquid films have a significant influence on combustion efficiency. To improve the combustion performance of DISI engines, better understandings of the spray-wall interaction and liquid film formation processes are needed. This work investigated the wall impingement and liquid film formation by sprays injected from a mini-sac injector with a single-hole. The experiments were conducted in a constant-volume vessel under various ambient pressure and temperature. A quartz glass with rough surface was used as the flat wall. The refractive index matching (RIM) technique was applied to investigate the spatial distribution and formation process of liquid films. The results showed that the adhered liquid mass and spatial distribution of liquid films, liquid film formation process are affected by the ambient pressure and temperature. In particular, the effect of ambient temperature on liquid film formation is significant. The results of RIM method provided insights into the effects of ambient conditions on the wall impingement behavior and liquid film formation processes.