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RISS 인기검색어
- 검색키워드
- 저자 : Tan Pui Yee (검색결과 2 건)
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Illicit drug use is associated with lower bone mineral density and bone strength
Suhas Krishnamoorthy,Gloria Hoi-Yee Li,Kelvin Shun-Cheong Ho,Yin-Pan Chau,Constance Mak,Donna Ng,Albert Kar-Kin Chung,Jody Kwok-Pui Chu,Kathryn Choon-Beng Tan,Ruby Lai-Chong Hoo,Ching-Lung Cheung 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.3
Objectives: To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck. Methods: This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using linear regression for BMD (lumbar spine and femoral neck) and hip geometrical parameters (cross-sectional area [CSA], cross-sectional moment of inertia [CSMI], section modulus [SM], average cortical thickness [ACT] and BMD at the narrow neck) after adjusting for age, body mass index (BMI), smoking status, drinking status, physical activity, and history of antipsychotic and antidepressant use. Mean difference and 95% confidence intervals (95% CI) were calculated between 108 illicit drug users and 108 controls using an adjusted linear model and cluster-robust standard errors after matching by age and sex. The false discovery rate was used to correct for multiple testing. Results: Illicit drug users had a significantly lower BMD (g/cm2 ) at the lumbar spine (mean difference: -0.062; 95% CI: -0.108 to − 0.015), and femoral neck (mean difference: -0.058; 95% CI: -0.106 to − 0.010) in the fully adjusted model. Illicit drug users also had a significantly lower CSA (mean difference: -0.238 cm2 ; 95% CI: -0.462 to − 0.013), ACT (mean difference: -0.018 cm; 95% CI: -0.030 to − 0.006) and BMD (mean difference: -0.070 g/ cm2 ; 95% CI: -0.128 to − 0.012) at the narrow neck. Conclusions: Illicit drug use is associated with lower BMD and bone strength. Future studies evaluating the risk of illicit drug use with fragility fracture are warranted.
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Association of DNA damage with vitamin D and hair heavy metals of obese women
Ng Chiat Yin,Amini Farahnaz,Ahmad Bustami Normina,Tan Eugenie Sin Sing,Tan Pui Yee,Mitra Soma Roy 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.4
Background Obesity has been linked to DNA damage. The modifiable risk factors may modulate the impact of obesity on DNA damage. Objective This study aimed to assess DNA damage and its association with dietary nutrient, serum 25-hydroxyvitamin D (25(OH)D) and concentration of hair heavy metals of obese and non-obese women. Method A case–control study was conducted involving 134 women aged between 20 and 50 years. Serum 25(OH)D, fasting glucose, and lipid profile were assessed. Indicators of DNA damage such as percentage of tail DNA, tail moment, tail olive moment, tail intensity and tail length were measured using an alkaline-comet assay. Concentrations of hair heavy metals were quantified using inductively coupled plasma–mass spectrometry (ICP–MS). Participants' daily energy, macro, and micronutrient intake were collected using the Food Frequency Questionnaire. Results Mean values of serum 25(OH)D was 31.8 ± 0.9 nmol/L. 96.3% of participants were vitamin D deficiency (< 50 nmol/L). The mean BMI was 26.3 ± 0.5 kg/m2. Half of the participants (50.7%) have a high frequency of DNA strand breaks. Mean concentration of hair heavy metals (mg/kg) were 0.1 ± 0.03 (arsenic), 0.2 ± 0.1 (cadmium), 1.0 ± 0.4 (mercury), 2.8 ± 0.8 (lead),and 6.2 ± 0.4 (chromium). There was no significant difference for the mean of serum 25(OH)D, indicators of DNA damage, concentrations of hair heavy metals and dietary nutrients between obese and non-obese groups (p > 0.05). Obese women with serum 25(OH)D level of ≥ 31 nmol/L had a significantly lower tail moment (p = 0.029) and tail olive moment (p = 0.031); thus, indicating less DNA damage. Additionally, obese women with hair chromium concentration of ≥ 5.88 mg/kg had a significantly higher tail moment (p = 0.047), indicating more DNA damage. Conclusion DNA damage among obese women correlated with serum 25(OH)D and hair chromium. Background Obesity has been linked to DNA damage. The modifiable risk factors may modulate the impact of obesity on DNA damage. Objective This study aimed to assess DNA damage and its association with dietary nutrient, serum 25-hydroxyvitamin D (25(OH)D) and concentration of hair heavy metals of obese and non-obese women. Method A case–control study was conducted involving 134 women aged between 20 and 50 years. Serum 25(OH)D, fasting glucose, and lipid profile were assessed. Indicators of DNA damage such as percentage of tail DNA, tail moment, tail olive moment, tail intensity and tail length were measured using an alkaline-comet assay. Concentrations of hair heavy metals were quantified using inductively coupled plasma–mass spectrometry (ICP–MS). Participants' daily energy, macro, and micronutrient intake were collected using the Food Frequency Questionnaire. Results Mean values of serum 25(OH)D was 31.8 ± 0.9 nmol/L. 96.3% of participants were vitamin D deficiency (< 50 nmol/L). The mean BMI was 26.3 ± 0.5 kg/m2. Half of the participants (50.7%) have a high frequency of DNA strand breaks. Mean concentration of hair heavy metals (mg/kg) were 0.1 ± 0.03 (arsenic), 0.2 ± 0.1 (cadmium), 1.0 ± 0.4 (mercury), 2.8 ± 0.8 (lead),and 6.2 ± 0.4 (chromium). There was no significant difference for the mean of serum 25(OH)D, indicators of DNA damage, concentrations of hair heavy metals and dietary nutrients between obese and non-obese groups (p > 0.05). Obese women with serum 25(OH)D level of ≥ 31 nmol/L had a significantly lower tail moment (p = 0.029) and tail olive moment (p = 0.031); thus, indicating less DNA damage. Additionally, obese women with hair chromium concentration of ≥ 5.88 mg/kg had a significantly higher tail moment (p = 0.047), indicating more DNA damage. Conclusion DNA damage among obese women correlated with serum 25(OH)D and hair chromium.
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