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A New Sesquiterpene and Other Terpenoid Constituents of Chisocheton penduliflorus
Phongmaykin, Jarinporn,Kumamoto, Takuya,Ishikawa, Tsutomu,Suttisri, Rutt,Saifah, Ekarin 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
A new aromadendrane sesquiterpene, allo-aromadendrane-10${\alpha}$, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10${\beta}$, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.
A New Sesquiterpene and Other Terpenoid Constituents ofChisocheton penduliflorus
Jarinporn Phongmaykin,Takuya Kumamoto,Rutt Suttisri,Tsutomu Ishikawa,Ekarin Saifah 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
A new aromadendrane sesquiterpene, allo-aromadendrane-10α, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane- 10 β, 14-diol (2) and allo-aromadendrane-10 β, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.