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Chemical Composition of Clausena lansium (Lour.) Skeels Leaves and Antifungal Activity
Vu Duc Nam,Fujimatsu Teruhisa,Takigawa Hirofumi,Kusuoku Hiroshi,Nguyen Minh Khoi,Le Viet Dung,Do Thi Ha,Hashimoto Hiroshi 한국생약학회 2016 Natural Product Sciences Vol.22 No.1
The first study on chemical constituents and biological activities of Clausena lansium (Lour.) Skeels (Rutaceae) growing in Vietnam has been done. Phytochemical investigation of n-hexane extract led to the isolation of five compounds: dihydroindicolactone (1), 8-geranyloxy psoralen (2), imperatorin (3), heraclenol (4) and indicolactone (5), in which this is the first report on the presence of dihydroindicolactone (1). Their structures were elucidated based on LC/MS/NMR hyphenated techniques as well as comparison with those of literature data. The n-hexane extract and its subfractions, ethanol 95% extract and several isolated compounds were evaluated for antifungal activity.