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      • KCI등재

        CrPt₃(001) 박막의 자성

        정태성(Tae Sung Jeong),제갈소영(Soyoung Jekal),임성현(S. H. Rhim),홍순철(S. C. Hong) 한국자기학회 2017 韓國磁氣學會誌 Vol.27 No.2

        CrPt₃ 합금은 큰 Kerr 효과를 보여 주는 강한 자기결정 이방성을 가지고 있고 흥미롭게도 훈트 제3법칙을 따르지 않는 것으로 알려져 있다. 본 연구에서는 CrPt₃ 합금 박막의 두께의 따른 자성과 자기결정 이방성의 변화를 제일원리계산 방법을 이용하여 연구하였다. 기준 자료로 활용하기 위해 덩치 CrPt₃의 다양한 자성 상태, 즉 강자성(FM), A-, C-, G-type 반강자성(A-, C-, G-AF)에 대한 계산을 우선 수행하였는데 덩치 CrPt3은 FM 상태가 안정하였고 이는 실험과 일치하였다. A-, C-, G-AF 상태가 FM 상태일 때 보다 총에너지가 각각 0.517, 0.591, 0.183 eV 만큼 높았고 Cr의 자기모멘트는 FM, A-, C-, G-AF 일 때 각각 2.782, 2.805, 2.794, 2.869 μB으로 확인되었다. CrPt₃(001) 박막의 표면은 CrPt 표면과 Pt 표면으로 두 종류의 원소 구성을 가질 수 있다. 각각의 표면에 대해 3층에서 9층까지 두께를 변화시켜 가면서 계산을 수행하였다. CrPt 표면의 3층 박막은 덩치와는 다르게 C-AF 상태가 FM 상태에 비해 8 meV 안정하였고 그 보다 두꺼운 5층, 7층, 9층 박막은 덩치처럼 FM 상태가 안정하였다. Pt 표면의 3층 박막은 C-AF 상태가 FM 상태에 비해 37 meV, 5층 박막은 G-AF이 FM 상태에 비해 54 meV 만큼 안정하였고 그 보다 두꺼운 7, 9층 박막은 덩치와 같이 FM 상태가 더 안정하였다. Recent study shows that ordered alloy of L1₂ XPt₃ (M= V, Cr, Mn, Co, and Fe) exhibits various magnetic phases such as ferromagnetic-to-antiferromagnetic transition at the MnPt₃ surface. Moreover, it has been argued that CrPt₃, in particular, possess large magnetocrystalline anisotropy and Kerr rotation with possible violation of Hund’s rule. As such, we extend our work to thickness dependence of the magnetic structure of CrPt₃ thin film using density functional theory. Magnetic ground state of the bulk CrPt₃ turns out to be ferromagnetic (FM), where other magnetic phases such as A-type (A-AF), C-type (C-AF), and G-type antiferromagnetic (GAF) state have higher total energies than FM by 0.517, 0.591, and 0.183 eV, respectively, and magnetic moments of Cr in bulk are respectively 2.807 (FM), 2.805 (A-AF), 2.794 (C-AF) and 2.869 μB (G-AF). We extend our study to CrPt₃(001) thin films with CrPtand Pt-termination. The thickness and surface-termination dependences of magnetism are investigated for 3-9 monolayers (ML), where different magnetic phases from bulk emerge: C-AF for CrPt-terminated 3ML and G-AF for Pt-terminated 5ML have energy difference relative to FM by 8 and 54 meV, respectively. Furthermore, thickness- and surface-termination-dependent magnetocrystalline anisotropies of the CrPt₃(001) films are discussed.

      • KCI등재

        CrPt<sub>3</sub>(001) 박막의 자성: 제일원리계산

        정태성,제갈소영,임성현,홍순철,Jeong, Tae Sung,Jekal, Soyoung,Rhim, S.H.,Hong, S.C. 한국자기학회 2017 韓國磁氣學會誌 Vol.27 No.2

        $CrPt_3$ 합금은 큰 Kerr 효과를 보여 주는 강한 자기결정 이방성을 가지고 있고 흥미롭게도 훈트 제3법칙을 따르지 않는 것으로 알려져 있다. 본 연구에서는 $CrPt_3$ 합금 박막의 두께의 따른 자성과 자기결정 이방성의 변화를 제일원리계산 방법을 이용하여 연구하였다. 기준 자료로 활용하기 위해 덩치 $CrPt_3$의 다양한 자성 상태, 즉 강자성(FM), A-, C-, G-type 반강자성(A-, C-, G-AF)에 대한 계산을 우선 수행하였는데 덩치 $CrPt_3$은 FM 상태가 안정하였고 이는 실험과 일치하였다. A-, C-, G-AF 상태가 FM 상태일 때 보다 총에너지가 각각 0.517, 0.591, 0.183 eV 만큼 높았고 Cr의 자기모멘트는 FM, A-, C-, G-AF 일 때 각각 2.782, 2.805, 2.794, $2.869_{{\mu}_B}$으로 확인되었다. $CrPt_3$(001) 박막의 표면은 CrPt 표면과 Pt 표면으로 두 종류의 원소 구성을 가질 수 있다. 각각의 표면에 대해 3층에서 9층까지 두께를 변화시켜 가면서 계산을 수행하였다. CrPt 표면의 3층 박막은 덩치와는 다르게 C-AF 상태가 FM 상태에 비해 8 meV 안정하였고 그 보다 두꺼운 5층, 7층, 9층 박막은 덩치처럼 FM 상태가 안정하였다. Pt 표면의 3층 박막은 C-AF 상태가 FM 상태에 비해 37 meV, 5층 박막은 G-AF이 FM 상태에 비해 54 meV 만큼 안정하였고 그 보다 두꺼운 7, 9층 박막은 덩치와 같이 FM 상태가 더 안정하였다. Recent study shows that ordered alloy of $L1_2$ $XPt_3$ (M = V, Cr, Mn, Co, and Fe) exhibits various magnetic phases such as ferromagnetic-to-antiferromagnetic transition at the $MnPt_3$ surface. Moreover, it has been argued that $CrPt_3$, in particular, possess large magnetocrystalline anisotropy and Kerr rotation with possible violation of Hund's rule. As such, we extend our work to thickness dependence of the magnetic structure of $CrPt_3$ thin film using density functional theory. Magnetic ground state of the bulk $CrPt_3$ turns out to be ferromagnetic (FM), where other magnetic phases such as A-type (A-AF), C-type (C-AF), and G-type antiferromagnetic (G-AF) state have higher total energies than FM by 0.517, 0.591, and 0.183 eV, respectively, and magnetic moments of Cr in bulk are respectively 2.807 (FM), 2.805 (A-AF), 2.794 (C-AF) and $2.869_{{\mu}_B}$ (G-AF). We extend our study to $CrPt_3$(001) thin films with CrPt-and Pt-termination. The thickness and surface-termination dependences of magnetism are investigated for 3-9 monolayers (ML), where different magnetic phases from bulk emerge: C-AF for CrPt-terminated 3 ML and G-AF for Pt-terminated 5 ML have energy difference relative to FM by 8 and 54 meV, respectively. Furthermore, thickness- and surface-termination-dependent magnetocrystalline anisotropies of the $CrPt_3$(001) films are discussed.

      • SCISCIESCOPUS

        Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

        Hwangbo, C,Tae, N,Lee, S,Kim, O,Park, O K,Kim, J,Kwon, S-H,Lee, J-H Macmillan Publishers Limited 2016 Oncogene Vol.35 No.3

        <P>Syntenin, a tandem PDZ domain containing scaffold protein, functions as a positive regulator of cancer cell progression in several human cancers. We report here that syntenin positively regulates transforming growth factor (TGF)-beta 1-mediated Smad activation and the epithelial-to-mesenchymal transition (EMT) by preventing caveolin-1-mediated internalization of TGF-beta type I receptor (T beta RI). Knockdown of syntenin suppressed TGF-beta 1-mediated cell migration, transcriptional responses and Smad2/3 activation in various types of cells; however, overexpression of syntenin facilitated TGF-beta 1-mediated responses. In particular, syntenin knockdown abolished both the basal and TGF-beta 1-mediated repression of E-cadherin expression, as well as induction of vimentin expression along with Snail and Slug upregulation; thus, blocking the TGF-beta 1-induced EMT in A549 cells. In contrast, overexpression of syntenin exhibited the opposite effect. Knockdown of syntenin-induced ubiquitination and degradation of T beta RI, but not TGF-beta type II receptor, leading to decreased T beta RI expression at the plasma membrane. Syntenin associated with T beta RI at its C-terminal domain and a syntenin mutant lacking C-terminal domain failed to increase TGF-beta 1-induced responses. Biochemical analyzes revealed that syntenin inhibited the interaction between caveolin-1 and T beta RI and knockdown of syntenin induced a massive internalization of T beta RI and caveolin-1 from lipid rafts, indicating that syntenin may increase TGF-beta signaling by inhibiting caveolin-1-dependent internalization of T beta RI. Moreover, a positive correlation between syntenin expression and phospho-Smad2 levels is observed in human lung tumors. Taken together, these findings demonstrate that syntenin may act as an important positive regulator of TGF-beta signaling by regulating caveolin-1-mediated internalization of T beta RI; thus, providing a novel function for syntenin that is linked to cancer progression.</P>

      • SCISCIESCOPUS

        Fabrication of superconducting MgB<sub>2</sub> thin films on textured Cu(100) tape by hybrid physical–chemical vapor deposition

        Lee, Tae Gyoung,Ranot, Mahipal,Seong, Won Kyung,Jung, Soon-Gil,Kang, W N,Joo, J H,Kim, C-J,Jun, B-H,Kim, Youngha,Zhao, Y,Dou, S X IOP Publishing Ltd 2009 Superconductor science & technology Vol.22 No.4

        <P>We report on the fabrication of superconducting MgB<SUB>2</SUB> thin films on textured Cu(100) tape under low pressure and temperature by using a hybrid physical–chemical vapor deposition (HPCVD) technique to explore the possible broad range of deposition. Thermodynamic calculations for the Mg–B system have been carried out and the pressure–temperature phase diagram was obtained. Our results demonstrate that the deposition of superconducting MgB<SUB>2</SUB> films is possible beyond the theoretically calculated growth window, where the sublimation of Mg is taking place. The structural and microstructural investigations reveal that MgB<SUB>2</SUB> films are <I>c</I>-axis-oriented normal to the substrate. The highest <I>J</I><SUB>c</SUB> of ∼1.34 × 10<SUP>5</SUP> A cm<SUP>−2</SUP> at 5 K under 3 T is obtained for the film grown at 460 °C. The critical current density (<I>J</I><SUB>c</SUB>) and flux pinning force density (<I>F</I><SUB>p</SUB>) of MgB<SUB>2</SUB> films are enhanced with decreasing growth temperature. This could be attributed to the high density of grain boundaries which may act as effective flux pinning centers. These findings suggest an alternative route to fabricate MgB<SUB>2</SUB> tapes at low temperature for large scale applications.</P>

      • Effect of weak interlayer coupling on critical fluctuation in high $T_c$ superconductors

        Kim, Jin-Tae,Kang, W.N.,Chung, S.H.,Ha, D.H.,Yoo, K.H.,Kim, M.S.,Lee, Sung-Ik,Park, Y.K.,Park, J.C. The Korean Superconductivity Society 1999 Progress in superconductivity Vol.1 No.1

        The magnetization and/or resistivity of high $T_c$ superconductors ($YBa_2Cu_3O_{7-\delta}$(YBCO) single crystal, $Bi_2Sr_2CaCu_2O_8$ (Bi-2212) single crystal, $Tl_2Ba_2CaCu_2O_8$ (Tl-2212) film, $HgBa_2Ca_2Cu_3O_8$ (Hg-1223) film) have been measured as a function of magnetic field H and temperature T. The extracted fluctuation part of the magnetization and conductivity exhibits a critical behavior consistent with the three-dimensional XY model. The dynamic critical exponent z does not sensitively vary with a type of the superconductors. The value of z ranges from 1.5 to $1.8{\pm}0.1$. However, the static critical exponent ${\nu}$ is the most largely increased in Tl-2212 that has a weaker interlayer coupling strength than YBCO; the value of ${\nu}$ is 0.669, 0.909, 1.19, and 1.338 for YBCO, Bi-2212, Hg-1223, and Tl-2212 respectively. The results indicate that the weak interlayer coupling along the c-axis of high $T_c$ superconductors near $T_c$ does not influence the dynamic critical exponent z (the same value of superfluid $^4He$), but significantly increases the static critical exponent ${\nu}$.

      • KCI등재

        림프절 전이가 없는 T3-4 직장암에서 예후인자의 분석

        박인자,김희철,김태원,김종훈,김정선,김정랑,유창식,김진천 대한소화기학회 2004 대한소화기학회지 Vol.43 No.1

        목적 . 림프절 전이가 없는 73-4 대장암은 수술적 치료만으로 약 50~80%의 5년 생존율이 보고되고 있어, 직장암의경우 방사선치료의 이점에 대한 논란이 있다. 본 연구는 림프절 전이가 없는73-4직장암의 임상적, 병리적 양상의 후향적 분석을 통하여 생존율과 재발에 관련 있는 인자를 확인하고 치료 방침을 정하고자 이루어진다. 대상 밑 방법:1989년 7월부터 1996년 12월까지 서울아산병원에서 근치적 수술을 시행한 직장암 환자 중 병리검사상 림프절 전이가 없고 암종의 침윤이 고유근층을 넘어선 73-4 환자 202명을 대상으로하였다. 대상군의 남녀 비는 136:66이었으며 평균 연령은 59 (9~85)세이었다. 추적 중 26예(12.9%)가 소실되었으며, 추적의 중간값은 50 (3~125)개월이었다. 결과:암종의 위치는 저직장 49예(24.3%), 중직장 69예(34.2%), 고직장 84예(41.6%)이었다. 수술은 전방절제술 1예, 저위전방절제술 94예, 저위전방절제술 및 대장항문문합술 22예, 복회음부절제술 83예 기타 2예가 시행되었다. 획득 림프절의 수는 7개 이하 27예(13.4%), B~14개 55예(27.2%), 15개이상 120예(59.4%)이었다. 술후 72예(35.6%)에서 화학요법이, 95예(47.0%)에서 화학 및 방사선 병합 요법이 시행되었다. 추적시 재발은 32예(18.2%)에서 발생하였고, 혈행 전이12예, 국소 재발 12예, 복막 전이 2예, 국소 재발 및 혈행전이 2예이었다. 추적군의 5년 생존율은 85.6%, 5년 무병생존율은 82.8%이었다. 임상,병리적 요소의 단변량 분석에서 암종의 세포형(p=0.05), 획득 림프절의 수(p<0.001)가 생존과 의미 있는 인자였고, 다변량 분석에서는 획득 림프절수만 의미 있었다. 암종의 위치에 따라 세분한 군의 다변량분석에서 고직장암의 경우 수술 전 혈청 암태아성 항원치(p=0.003) 및 절제연의 거리(p=0.025)가, 중직장암의 경우 획득 림프절 수(p=0.0019)가, 저직장암의 경우 술전 혈청암태아성 항원치(p=0.008), 암종의 크기(p=0.02), 육안적 형태(p=0.026), 획득 림프절 수(p=0.006)가 예후와 의미 있게 관련이 있었다. 결론: 획득 림프절 수와 생존율과의 연관은 특히 중,저직장암의 수술시 철저한 근치 절제가 중요함을 시사하는 소견이며, 본 연구에서 술후 방사선치료의 효과가 없었을지라도, 예후가 불량할 것으로 추정되는 H기 직장암의 경우 고려될 수 있을 것이다. Background/Aims: We aimed to verify the prognostic factors of stage I1 rectal cancer and the effect of radiation therapy on the survival and local recurrence rate. Methods: This study was undertaken in 202 patients who underwent curative resection of rectal cancer and confirmed to be stage 11 between July 1989 and December 1996. Univariate and multivariate (Cox's model) analyses of survival were employed to identify prognostic factors. Statistical significance was assigned by p value of <0.05. Results: Overall recurrence occurred in 32 patients. Four patterns of recurrence were observed: hematogenous recurrence in 17 patients, local recurrence in 11, peritoneal seeding in two and simultaneous hematogenous and local recurrence in two cases. Overall 5-year survival rate was 85.6% and 5 year disease free survival rate was 82.8%. There was no significant difference in local recurrence rate and survival according to radiation therapy or location of cancer. In multivariate analysis, the number of harvested lymph node was only a prognostic factor. Conclusions: The number of harvested lymph nodes has prognostic value in stage Ⅱ rectal cancer. Postoperative radiation therapy should be considered for stage Ⅱ rectal cancer with poor prognostic factors although radiation did not decrease local recurrence rate in present study. (Korean J Gastroenterol 2004;43:23-28)

      • 비대칭적인 열 및 물질전달이 있는 수직채널에서의 자연대류 해석

        태춘섭,이충구 충북대학교 건설기술연구소 1998 建設技術論文集 Vol.17 No.1

        This study aims to investigate theoretically the role of heat and mass transfer, in connection with the vaporisation of thin liquid film on the lower girt of inside channel, in natural convection flows driven by the buoyancy forces of thermal and mass diffusion. The upper surface provides a uniform heat flux, though asymmetric. The FDM(Finite Difference Method) was used to solve the governing equations of laminar natural connective channel flow. The relationship between the dimensionless flow rate and Grashof number was presented graphically in terms of the ratio of wet- or dry-pant channel length to the heated length. The result of this study elucidated the important role of liquid film in laminar natural connective flows.

      • Hitachi 747 자동분석기의 실험평가

        박종성,황성준,이승관,이창규,이국성,강영태 高麗大學校 倂設 保健大學 保健科學硏究所 1994 保健科學論集 Vol.20 No.1

        Comparison of methods studies should compare results by new or proposed method with those by a reference quality method or other generally accepted analytical method for which the performance is documented. The least squares method is frequently used to calculate the slope and intercept of the best line through a set of data points. However, least squares regression slopes and intercepts may be incorrect if the underlying assumptions of the least squares model are not met. Latest in the line of Hitachi systems, the Hitachi 747 is a high volume, random access system. It has capabilities for running states, automatic return of samples with a smaller volume, parameters for serum/plasma and urine, and multitasking capability. We performed method comparison studies against the current method for 8 different analytes with 49 samples for each chemistry. Also, Data analysis was performed according to the Kuwa protocol. The results of statistical studies indicate an acceptable performance over a clinically relevant range. We conclude that the Hitachi 747 analyzer is a reliable, precise and accurate system for routine clinical analytes. Its convenience and simplicity make it superior to the current autoanalyzer for our clinical applications in a hospital setting.

      • Suspension Characteristics and Rheological Properties of Aqueous Alumina/Zirconia Freeze Casting Slurries

        Lyu, Seung Woo,Park, Young Min,Yang, Tae Young,Ryu, S.C.,Stevens, Ron,Park, Hong Chae Trans Tech Publications, Ltd. 2007 Key engineering materials Vol.336 No.-

        <P>The dispersion and rheological behavior of aqueous alumina, zirconia, and mixed alumina/ zirconia slurries have been studied in terms of solid loading and the incorporated multiple processing additives. Darvan-C, Dynol 604, Glycerol, and PVA were used as the dispersant, surfactant, cryoprotectant, and binder, respectively. Sedimentation density increased significantly on adding the dispersant; its effectiveness was similar for both the alumina and zirconia suspensions. With further addition of binder, the sedimentation density decreased. The suspension viscosity generally behaved in an opposite manner to the sedimentation density, i.e., low sedimentation density gave high low-shear viscosity, indicative of high order structure formation in the suspended particles. Shear rate rheology of suspensions with high dispersant content showed a shear thinning but with low dispersant content (≤2 wt.%), however, it showed a shear thickening at high shear rate (>600 s-1).</P>

      • Risk factors of nonadherence to colonoscopy surveillance after polypectomy and its impact on clinical outcomes: a KASID multicenter study

        Tae, C. H.,Moon, C. M.,Kim, S. E.,Jung, S. A.,Eun, C. S.,Park, J. J.,Seo, G. S.,Cha, J. M.,Park, S. C.,Chun, J. Springer Science + Business Media 2017 Journal of gastroenterology Vol.52 No.7

        <P>Conclusions Women, having undergone the procedure in small-to-medium-sized cities and the presence of an HRA at the index colonoscopy were found to be independent risk factors for late surveillance colonoscopy. Late surveillance is significantly predictive of subsequent HRA or CRC.</P>

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