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- 저자 : Sze Lin Tan (검색결과 2 건)
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Tiffany Sin Hui Bong,Jun Kiat Thaddaeus Tan,Juliana Teng Swan Ho,Puay Hoon Tan,Wing Sze Lau,Tuan Meng Tan,Jill Su Lin Wong,Veronique Kiak Mien Tan,Benita Kiat Tee Tan,Preetha Madhukumar,Wei Sean Yong 한국유방암학회 2022 Journal of breast cancer Vol.25 No.1
Purpose This study identified factors predicting malignant upgrade for atypical ductal hyperplasia (ADH) diagnosed on core-needle biopsy (CNB) and developed a nomogram to facilitate evidence-based decision making. Methods This retrospective analysis included women diagnosed with ADH at the National Cancer Centre Singapore (NCCS) in 2010–2015. Cox proportional hazards regression was used to identify clinical, radiological, and histological factors associated with malignant upgrade. A nomogram was constructed using variables with the strongest associations in multivariate analysis. Multivariable logistic regression coefficients were used to estimate the predicted probability of upgrade for each factor combination. Results Between 2010 and 2015, 238,122 women underwent mammographic screening under the National Breast Cancer Screening Program. Among 29,564 women recalled, 5,971 CNBs were performed. Of these, 2,876 underwent CNBs at NCCS, with 88 patients (90 lesions) diagnosed with ADH and 26 lesions upgraded to breast malignancy on excision biopsy. In univariate analysis, factors associated with malignant upgrade were the presence of a mass on ultrasound (p = 0.018) or mammography (p = 0.026), microcalcifications (p = 0.047), diffuse microcalcification distribution (p = 0.034), mammographic parenchymal density (p = 0.008). and ≥ 3 separate ADH foci found on biopsy (p = 0.024). Mammographic parenchymal density (hazard ratio [HR], 0.04; 95% confidence interval [CI], 0.005–0.35; p = 0.014), presence of a mass on ultrasound (HR, 10.50; 95% CI, 9.21–25.2; p = 0.010), and number of ADH foci (HR, 1.877; 95% CI, 1.831–1.920; p = 0.002) remained significant in multivariate analysis and were included in the nomogram. Conclusion Our model provided good discrimination of breast cancer risk prediction (C-statistic of 0.81; 95% CI, 0.74–0.88) and selected for a subset of women at low risk (2.1%) of malignant upgrade, who may avoid surgical excision following a CNB diagnosis of ADH.
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Sakinah Harith,Sze Lin Tan 대한노인병학회 2020 Annals of geriatric medicine and research Vol.24 No.2
Background: This study aimed to translate and validate the comprehensive geriatric assessment (CGA) questionnaire among older adult patients in Malaysia in the Malay language. Methods: The questionnaire contained items on the socio-demographic characteristics, medical condition, quality of life (QOL), nutritional status, functional capacity, and depression status. The forward and backward translation processes of the original English language version of the questionnaire were undertaken by three independent linguistic translators, while its content was validated by an expert team consisting of seven geriatricians, physicians, dietitian, and lecturers. The Malay version of the questionnaire was tested for face validity in 10 older adult patients over 65 years of age admitted to the medical wards in Hospital Universiti Sains Malaysia (HUSM), Malaysia. The internal consistency reliability and construct validity were evaluated among 166 older adult patients (mean age, 71.0 years; 73.5% male) at the Medical Outpatients Department and medical wards of Hospital Sultanah Nur Zahirah (HSNZ), Kuala Terengganu, Malaysia. The questionnaire was administered through face-to-face interviews with the patients. Minor amendments were made after the content and face validity tests. Results: The internal consistency reliability was good, as the Cronbach’s alpha for most of the scales surpassed 0.70, ranging from 0.70 to 0.98, with only one exception (Mini Nutritional Assessment Short-Form, Cronbach’s alpha=0.62). The factor loadings for all scales were satisfactory (>0.40), ranging from 0.45 to 0.90. Conclusion: The Malay-version CGA showed evidence of satisfactory internal consistency reliability and construct validity in Malaysian geriatric patients. Therefore, it is recommended to be used for the assessment of the QOL, nutritional, functional, and depression status in this population.
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