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- 저자 : Syed Ibrahim Rizvi (검색결과 2 건)
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Role of red grape polyphenols as antidiabetic agents
Kanti Bhooshan Pandey,Syed Ibrahim Rizvi 한국한의학연구원 2014 Integrative Medicine Research Vol.3 No.3
The worldwide incidence of diabetes mellitus has reached alarming proportions. Persistent hyperglycemia due to impaired insulin activity and/or insulin resistance inversely affects the retina, cerebrovascular system, kidney, peripheral limbs, and other parts of the body, which leads to life-threatening complications. The causal role of oxidative stress in the development and progression of diabetic complications has been emphasized. Polyphenols present in natural products have gained much attention in recent decades in preventive studies against diabetes-associated pathologies. In the present review, we provide a comparative update on the role of quercetin, myricetin, and resveratrol—the major polyphenols present in red grapes—in intervening with diabetic complications, and a brief highlight on the molecular mechanisms underlying oxidative stress mediated hyperglycemia.
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Brahm Kumar Tiwari,Syed Ibrahim Rizvi,Kanti Bhooshan Pandey,Nidhi Jaiswal,A. B. Abidi 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.3
Use of plant based remedies for the preventionand treatment of diabetic complications over conventionaltherapies have received much emphasis in recent years. Present study was performed to evaluate the protectiveeffect of composite extract (CE) of leaves of Aeglemarmelos, Ocimum sanctum, Murraya koenigii and Azadirachtaindica on biochemical alterations in alloxan(ALX) induced diabetic wistar rats. Diabetes was inducedin rats by a single administration of ALX (150 mg/kgintraperitoneal (i.p) and CE at three different doses (25, 50and 100 mg/kg/bw/day) were administrated orally in threegroup of diabetic rats for 35 days. Another group of samenumber of diabetic rats were administrated by insulin(6 unit/kg/bw/day) by subcutaneous injection for 35 days andused as standard. Results showed that oral administration ofCE significantly protected the biochemical impairments indiabetic rats as evidenced by restoration of glutathionedepletion, ascorbic acid level, plasma antioxidant valuesand inhibition of lipid peroxidation. The outcome of thestudy suggests that CE of A. marmelos, O. sanctum, M. koenigii and A. indica leaves mimics insulin and passescapacity to ameliorate the hyperglycemia induced cellularcomplications thus may control the development and progressionof diabetes.
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