http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Suyi Zhang (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Fang Ting,Liu Suyi,Chen Liying,Ren Yating,Lu Dingqi,Yao Xinyi,Hong Tao,Zhang Xvfeng,Xie Zhimin,Yang Kepeng,Wang Xinchang 한국유전학회 2023 Genes & Genomics Vol.45 No.9
Background As a multisystemic autoimmune illness, the basic mechanisms behind the pathophysiology of systemic lupus erythematosus (SLE) remain poorly understood. Objective We aimed to investigate the possible significance of SLE’s DNA methylation and gain further insight into potential SLE-related biomarkers and therapeutic targets. Methods We used whole genome bisulfite sequencing (WGBS) method to analyze DNA methylation in 4 SLE patients and 4 healthy people. Results 702 differentially methylated regions (DMRs) were identified, and 480 DMR-associated genes were annotated. We found the majority of the DMR-associated elements were enriched in repeat and gene bodies. The top 10 hub genes identified were LCK, FYB, PTK2B, LYN, CTNNB1, MAPK1, GNAQ, PRKCA, ABL1, and CD247. Compared to the control group, LCK and PTK2B had considerably decreased levels of mRNA expression in the SLE group. Receiver operating characteristic (ROC) curve suggested that LCK and PTK2B may be potential candidate biomarkers to predict SLE. Conclusions Our study improved comprehension of the DNA methylation patterns of SLE and identified potential biomarkers and therapeutic targets for SLE.
-
Suqi Chen,Jun Huang,Hui Qin,Rongqing Zhou,Yan Yang,Chuanfeng Qiu,Suyi Zhang 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.10
The differences of interaction between interphasemicrobial communities were evaluated caused bytwo kinds of Daqu, including conventional Daqu (CDQ)and fortified Daqu (FDQ). The community diversity,functional genera and metabolites in pit mud (PM) andZaopei (ZP) were investigated by polyphasic detectingapproaches. FDQ evolved the core microbial communityfitting Baijiu brewing faster than CDQ. Compared withCPM, the abundance of Aspergillus, Hyphopichia, andPenicillium in FPM were 1.54, 14.75, and 1.68 times, whilethat of Lactobacillus, Bacillus, Methanobrevibacter, andMethanosaeta were 2.13, 1.85, 6.35, and 3.36 times,respectively. Furthermore, the content of key flavor componentswas increased in ZP using FDQ. These resultssuggested the interaction between interphase microbialcommunities in various phases of Baijiu fermentationniches was significant influenced by Daqu. It can not onlyenhance the key volatiles in ZP but also evolve the communityto fit Baijiu fermentation by introducing functionalgenera to Daqu.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
