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Clinical Evaluation of Human Papillomavirus DNA Genotyping Assay to Diagnose Women Cervical Cancer
Sunghyun Kim,Dongsup Lee,Yeun Kim,Geehyuk Kim,Sangjung Park,Yeonim Choi,Tae Ue Kim,Kwang Hwa Park,Hyeyoung Lee 대한의생명과학회 2012 Biomedical Science Letters Vol.18 No.2
In this study, we evaluated the human papillomavirus (HPV) genotyping test called MolecuTech REBA HPV-ID® (YD Diagnostics, Seoul, Korea) for 704 women who also had cervical cytological evaluations by Thin Prep. The infection rate of high-risk HPV genotypes was 56.6% in patients with normal cytology, 59.8% in those with benign, low-grade squamous intraepithelial lesions, 51.4% in those with atypical squamous cells of uncertain significance, 92.3% in those with high-grade squamous intraepithelial lesions, and 94.1% in those with squamous cell carcinoma or adenocarcinoma. HPV 16 was the most common genotype detected in any lesion, followed by HPV 53, 58, 33, 52, 45, 31, and 35, in order. The HPV DNA test with PCR-REBA is a very highly sensitive, but less specific, method. The infection rates and HPV genotype distribution of non-Korean people versus people from South Korea showed regional differences.
Cohort-based evacuation time estimation using TSIS-CORSIM
Park, Sunghyun,Sohn, Seokwoo,Jae, Moosung Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.6
Evacuation Time Estimate (ETE) can provide decision-makers with a likelihood to implement evacuation of a population with radiation exposure risk by a nuclear power plant. Thus, the ETE is essential for developing an emergency response preparedness. However, studies on ETE have not been conducted adequately in Korea to date. In this study, different cohorts were selected based on assumptions. Existing local data were collected to construct a multi-model network by TSIS-CORSIM code. Furthermore, several links were aggregated to make simple calculations, and post-processing was conducted for dealing with the stochastic property of TSIS-CORSIM. The average speed of each cohort was calculated by the link aggregation and post-processing, and the evacuation time was estimated. As a result, the average cohort-based evacuation time was estimated as 2.4-6.8 h, and the average clearance time from ten simulations in 26 km was calculated as 27.3 h. Through this study, uncertainty factors to ETE results, such as classifying cohorts, degree of model complexity, traffic volume outside of the network, were identified. Various studies related to these factors will be needed to improve ETE's methodology and obtain the reliability of ETE results.
Park, Sunghyun,Choi, Keunsu,Yu, Hyun Jung,Won, Young-June,Kim, Chaehoon,Choi, Minkee,Cho, So-Hye,Lee, Jung-Hyun,Lee, Seung Yong,Lee, Jong Suk American Chemical Society 2018 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.57 No.13
<P>Tetraethylenepentamine (TEPA), consisting mainly of primary and secondary amines, exhibits a high CO<SUB>2</SUB> sorption capacity; however, its poor thermal stability hampers practical utilization in the temperature swing adsorption process for CO<SUB>2</SUB> capture. Here, a facile functionalization of TEPA with 1,2-epoxybutane (EB) substantially enhanced its thermal stability as well as the CO<SUB>2</SUB> adsorption kinetics. Our careful analysis on the liquid-state <SUP>13</SUP>C NMR disclosed the amine state distribution of EB-functionalized TEPA (EB-TEPA). Although the increase in tertiary amine portion induced by EB-functionalization reduced CO<SUB>2</SUB> sorption capacity, the 0.64EB-TEPA (i.e., TEPA functionalized with EB with a TEPA/EB molar ratio of 1:3)/SiO<SUB>2</SUB> showed an excellent long-term stability over the 10 consecutive cycles of adsorption/desorption processes with a CO<SUB>2</SUB> swing capacity of 2.0 mmol CO<SUB>2</SUB> g<SUP>-1</SUP> under dry CO<SUB>2</SUB>/N<SUB>2</SUB> (15/85 mol/mol) feed conditions. Also, the first-principles calculation identified the configuration of modified TEPA molecules with XRD measurements, supporting an easy access of CO<SUB>2</SUB> into amine moieties of our modified TEPA molecules.</P> [FIG OMISSION]</BR>
Park, Sunghyun,Kim, Jongsik,Won, Young-June,Kim, Chaehoon,Choi, Minkee,Jung, Wonho,Lee, Kwang Soon,Na, Jeong-Geol,Cho, So-Hye,Lee, Seung Yong,Lee, Jong Suk American Chemical Society 2018 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.57 No.42
<P>Creating a module that achieves sustainable CO<SUB>2</SUB> capture while being compatible with the existing industry is paramount in overcoming the current CO<SUB>2</SUB>-driven environmental issues. This paper presents the fabrication of hollow fiber sorbents (HFSs) and their respective modules to capture CO<SUB>2</SUB> by the rapid thermal swing adsorption process (RTSA). Poly(amide-imide) (PAI)/microspheric SiO<SUB>2</SUB> composites were fabricated with a <I>so-called</I> “sieve-in-a-cage” microarchitecture which promotes CO<SUB>2</SUB> diffusion. More importantly, a selected amount of 1,2-epoxybutane (EB)-functionalized poly(ethylenimine) (PEI), denoted as 0.37EB-PEI, was incorporated into our PAI/SiO<SUB>2</SUB> composites forming PAI/SiO<SUB>2</SUB>/0.37EB-PEI HFSs which enhanced the thermal stability with a moderate CO<SUB>2</SUB> sorption uptake of 0.88 mmol CO<SUB>2</SUB> g<SUP>-1</SUP>. The resulting HFSs were assembled into a module using either stainless steel (SS) or poly(tetrafluoroethylene) (PTFE), and their respective CO<SUB>2</SUB>-capturing performances in the RTSA process were compared. The two modules had a comparable breakthrough CO<SUB>2</SUB> capacity of 0.42 mmol CO<SUB>2</SUB> g<SUP>-1</SUP> for a wet feed mixture of CO<SUB>2</SUB>/He/N<SUB>2</SUB> (14 mol/14 mol/72 mol) (RH 100%) and a comparable CO<SUB>2</SUB> desorption efficiency (i.e., 95% desorption within 2 min) under 100% CO<SUB>2</SUB> at 120 °C due to the presence of the 0.37EB-PEI; however, different thermal properties inherent to the modular materials caused the PTFE-based module to outperform the SS-based counterpart in terms of cooling, enabling the execution of an entire RTSA cycle within 8 min. Additionally, the PAI/SiO<SUB>2</SUB>/0.37EB-PEI/PTFE module maintained its breakthrough capacity of 0.42 mmol CO<SUB>2</SUB> g<SUP>-1</SUP> over five consecutive RTSA cycles, confirming its good long-term stability as well.</P> [FIG OMISSION]</BR>
Maternal Depression and Children's Screen Overuse
Park, Sunghyun,Chang, Hyoung Yoon,Park, Eun-Jin,Yoo, Heejeong,Jo, Woodong,Kim, Sung-Ju,Shin, Yunmi KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.34
<P><B>Background</B></P><P>It is known that there are various factors associated with children's screen overuse. The aim of this study was to examine the effect of maternal depression on 2–5-year-old children's overuse of various household screen devices.</P><P><B>Methods</B></P><P>Participants were from the Internet-Cohort for Understanding of internet addiction Risk factors/Rescue in Early livelihood (I-CURE) study, an observational prospective cohort study in Korea. Screen time for six types of screen devices (smartphone, television, computer, tablet, video gaming console, and portable gaming console) were assessed by parental questionnaire. Maternal depression was measured by the Korean version of the Beck Depression Inventory II. Logistic regression models were run to determine the association between maternal depression and children's screen overuse.</P><P><B>Results</B></P><P>Maternal depression was associated with children's television overuse after adjusting for other factors (odds ratio, 1.954; <I>P</I> = 0.034). Contrary to expectation, the relationship between maternal depression and screen time was not present on other devices such as smartphones, computers and tablets.</P><P><B>Conclusion</B></P><P>Maternal depression is related with 2–5-year-old children's television overuse. Interventions in maternal depressive symptoms and the associated changes in parent-child relationship can be useful for preventing children's television overuse.</P>
Park, Shinjun,Park, Sunghyun,Kim, Yongyoun International Academy of Physical Therapy Research 2019 Journal of International Academy of Physical Ther Vol.10 No.3
Background: Stroke patients have leg muscle weakness and impaired balance resulting in compensatory changes. To restore balance in these patients, functional training using postural strategy is needed. Objective: To examine the effects of ankle and hip strategy training on the center of pressure (COP) movement and limits of stability (LOS) in standing posture in stroke patients. Design: The study was an assessor-blinded and randomized-controlled clinical trial. Methods: Thirty patients were randomly assigned to an ankle strategy training group and a ankle/ hip strategy training group. Patients in the ankle strategy training group underwent ankle strategy exercise for 30 min, and those in the ankle/ hip strategy training group underwent 15 min of ankle strategy exercise and 15 min of hip strategy exercise. Both groups underwent training thrice a week for four weeks. Forward, backward, paretic side, and non-paretic side COP movements and LOS were measured using BioRescue. Results: After the intervention, except for the backward area in the ankle strategy training group, the COP movement area and the LOS were significantly improved in both the groups. In addition, these improvements were significantly higher in ankle/ hip strategy training group than that in the ankle strategy training group. Conclusions: Ankle strategy training in addition to hip strategy training improves COP movement (forward-backward, paretic side area, and non-paretic side area) and LOS in stroke patients.
HER2-specific aptide conjugated magneto-nanoclusters for potential breast cancer imaging and therapy
Park, Jinho,Park, Seho,Kim, Sunghyun,Lee, In-Hyun,Saw, Phei Er,Lee, Kwangyeol,Kim, Yong-Chul,Kim, Young-Joon,Farokhzad, Omid C.,Jeong, Yong Yeon,Jon, Sangyong The Royal Society of Chemistry 2013 Journal of materials chemistry. B, Materials for b Vol.1 No.36